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Dergiler / Kocatepe Veteriner Dergisi / 2026 / Cilt: 19 Sayı: 2

Erkek kuzularda testiküler gelişimi, hemodinamiği ve testosteron düzeyini iyileştirmek amacıyla intratestiküler trombositten zengin plazma (PRP) uygulaması

Intratesticular platelet-rich plasma (PRP) application to improve testicular development, hemodynamic and testosterone in male lambs

Aslıhan Çakır Cihangiroğlu(Siirt University, Faculty of Veterinary Medicine, Department of Reproduction and Artificial Insemination)0000-0003-3365-8960
Gaffari Türk(Fırat University, Faculty of Veterinary Medicine, Department of Reproduction and Artificial Insemination)0000-0001-7417-1038
İbrahim Halil Güngör(Fırat University, Faculty of Veterinary Medicine, Department of Reproduction and Artificial Insemination)0000-0002-5250-1478
Tutku Can Acısu(Fırat University, Faculty of Veterinary Medicine, Department of Reproduction and Artificial Insemination)0000-0002-0882-937X
Nida Badıllı(Fırat University, Faculty of Veterinary Medicine, Department of Reproduction and Artificial Insemination)0000-0002-1007-9723
Şuheda Yüksel(Fırat University, Faculty of Veterinary Medicine, Department of Reproduction and Artificial Insemination)0009-0004-0895-3014
Fatma Fırat Daniş(Fırat University, Faculty of Veterinary Medicine, Department of Reproduction and Artificial Insemination)0000-0002-0165-7958
Şeyma Özer Kaya(Fırat University, Faculty of Veterinary Medicine, Department of Reproduction and Artificial Insemination)0000-0002-9970-9364
Seyfettin Gür(Fırat University, Faculty of Veterinary Medicine, Department of Reproduction and Artificial Insemination)0000-0003-0096-2501
Mustafa Sönmez(Fırat University, Faculty of Veterinary Medicine, Department of Reproduction and Artificial Insemination)0000-0003-0281-7228
Sayfa
172–199
Yayın Tarihi
2026-06-15
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⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

Erken yaşta kuzulara PRP uygulanmasının, PRP içeriğinde bulunan bazı büyüme faktörlerine bağlı olarak testiküler gelişim üzerinde hafif düzeyde olumlu bir etki gösterebileceği düşünülmektedir.

📌 3 Maddede Bu Makale

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Amaç & Hipotez:Bu çalışmanın amacı, erkek kuzularda periyodik intratestiküler PRP uygulamasının testiküler gelişim üzerine etkisini; testosteron düzeyleri, testiküler morfometri ve supratestiküler arter hemodinamiğindeki değişiklikleri inceleyerek değerlendirmektir.
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Temel Bulgular & Veri:Kontrol grubundaki kuzulara (n=16) intratestiküler serum fizyolojik enjeksiyonu uygulanırken, deney grubundaki kuzulara (n=16) otolog PRP uygulanmıştır.
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Sonuç & Katkı:Erken yaşta kuzulara PRP uygulanmasının, PRP içeriğinde bulunan bazı büyüme faktörlerine bağlı olarak testiküler gelişim üzerinde hafif düzeyde olumlu bir etki gösterebileceği düşünülmektedir.
🔬Tür:Deneysel Tarla Denemesi
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Kuzu · Platelet-rich plasma · Testosteron

Özet

Bu çalışmanın amacı, erkek kuzularda periyodik intratestiküler PRP uygulamasının testiküler gelişim üzerine etkisini; testosteron düzeyleri, testiküler morfometri ve supratestiküler arter hemodinamiğindeki değişiklikleri inceleyerek değerlendirmektir. Kontrol grubundaki kuzulara (n=16) intratestiküler serum fizyolojik enjeksiyonu uygulanırken, deney grubundaki kuzulara (n=16) otolog PRP uygulanmıştır. Enjeksiyonlar 10 ay boyunca aylık olarak gerçekleştirilmiştir. Haziran ayında yapılan ilk PRP uygulamasını takiben, testosteron düzeyleri, testiküler morfometrik ölçümler ve spermatik kordon Doppler ultrasonografi ölçümleri 10 ay süreyle (Temmuz–Nisan) aylık olarak değerlendirilmiştir. Ayrıca tam kanda ve PRP’de trombosit sayıları ile PRP’deki büyüme faktörü düzeyleri analiz edilmiştir. PRP grubunda, Ekim ayında testiküler kan akımı, Aralık ayında skrotal kalınlık ve Nisan ayında testiküler uzunluk kontrol grubuna kıyasla anlamlı derecede daha yüksek bulunmuştur (p<0,05). Ayrıca Doppler ultrasonografi parametrelerinden direnç indeksi değerinin PRP grubunda kontrol grubuna göre daha düşük olduğu belirlenmiştir (p<0,05). Tam kandaki trombosit sayılarında (p<0,001), PRP’deki trombosit sayılarında (p<0,001) ve PRP’deki FGF1 düzeylerinde (p<0,05) aylar arasında anlamlı farklılıklar gözlenmiştir. Erken yaşta kuzulara PRP uygulanmasının, PRP içeriğinde bulunan bazı büyüme faktörlerine bağlı olarak testiküler gelişim üzerinde hafif düzeyde olumlu bir etki gösterebileceği düşünülmektedir.

Abstract

The purpose of this study was to evaluate the effect of periodic intratesticular PRP administration on testicular development in male lambs by examining the changes in testosterone levels, testicular morphometry, and supratesticular artery hemodynamic. The control group lambs (n=16) received an intratesticular injection of saline solution, while the experimental group lambs (n=16) were administered autologous PRP. Injections were administered monthly for a period of 10 months. Following the initial PRP injection in June, testosterone levels, testicular morphometric measurements, and spermatic cord Doppler ultrasonography measurements were assessed on a monthly basis for a period of 10 months (July to April). Platelet counts in whole blood and PRP, and growth factor levels in PRP were also analysed. Testicular blood flow in October, scrotal thickness in December, and testicular length in April were significantly higher in the PRP group compared to the control group (p<0.05). Furthermore, the resistance index value among Doppler ultrasonography parameters was observed to be lower in the PRP group compared to the control group (p<0.05). Significant inter-month differences were observed in platelet counts in whole blood (p<0.001) and PRP (p<0.001), as well as in FGF1 levels in PRP (p<0.05). It is hypothesized that the administration of PRP to lambs at an early age may exert a slight beneficial influence on testicular development, attributable to the presence of certain growth factors within the PRP.

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Bu Makaleye Atıf Yap

Cihangiroğlu, A. Ç., Türk, G., Güngör, İ. H., Acısu, T. C., Badıllı, N., Yüksel, Ş., Daniş, F. F., Kaya, Ş. Ö., Gür, S., Sönmez, M. (2026). Erkek kuzularda testiküler gelişimi, hemodinamiği ve testosteron düzeyini iyileştirmek amacıyla intratestiküler trombositten zengin plazma (PRP) uygulaması. Kocatepe Veteriner Dergisi, Cilt: 19 Sayı: 2, 172–199. https://doi.org/10.30607/kvj.1890400

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