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Dergiler / Kocatepe Veteriner Dergisi / 2026 / Cilt: 19 Sayı: 3

Gebelik Toksemisi Olan Keçilerde Plasentom Perfüzyonunun Değerlendirilmesi

Evaluation of Placentome Perfusion in Goats with Pregnancy Toxemia

Ömer Yaprakcı(HARRAN ÜNİVERSİTESİ)0000-0002-7784-9438
Tuğra Akkuş(HARRAN ÜNİVERSİTESİ)0000-0002-6002-5942
Sayfa
404–414
Yayın Tarihi
2026-09-15
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⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

Sonuç olarak, keçilerde gebelik toksemisinin plasental kan akımında önemli değişikliklere yol açtığı ve Doppler ultrasonografi parametrelerinin gebeliğin ileri dönemlerinde hastalığın tanısında değerli bir araç olabileceği belirlendi.

📌 3 Maddede Bu Makale

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Amaç & Hipotez:Sunulan çalışmanın amacı, keçilerde gebelik toksemisinin (PT) plasental kan akımı üzerindeki etkilerini belirlemektir.
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Temel Bulgular & Veri:Kontrol grubu (n=15), β-hidroksibütirik asit (BHBA) konsantrasyonu <0.8 mmol/L olan keçilerden; subklinik PT grubu (n=15), BHBA konsantrasyonu 0.8–1.6 mmol/L arasında olan keçilerden; klinik PT grubu (n=15) ise BHBA konsantrasyonu 1.6–5 mmol/L arasında olan keçilerden oluşturuldu.
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Sonuç & Katkı:Sonuç olarak, keçilerde gebelik toksemisinin plasental kan akımında önemli değişikliklere yol açtığı ve Doppler ultrasonografi parametrelerinin gebeliğin ileri dönemlerinde hastalığın tanısında değerli bir araç olabileceği belirlendi.
🔬Tür:Araştırma Makalesi
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Doppler · Gebelik Toksemisi · Keçi

Özet

Sunulan çalışmanın amacı, keçilerde gebelik toksemisinin (PT) plasental kan akımı üzerindeki etkilerini belirlemektir. Kontrol grubu (n=15), β-hidroksibütirik asit (BHBA) konsantrasyonu <0.8 mmol/L olan keçilerden; subklinik PT grubu (n=15), BHBA konsantrasyonu 0.8–1.6 mmol/L arasında olan keçilerden; klinik PT grubu (n=15) ise BHBA konsantrasyonu 1.6–5 mmol/L arasında olan keçilerden oluşturuldu. Herhangi bir tedavi veya uygulama öncesinde, tüm keçilerde karunkular ve kotiledoner arterler Pulse Doppler ultrasonografi (USG) ile değerlendirildi. Ayrıca, non-esterifiye yağ asidi (NEFA) ve nitrik oksit (NO) konsantrasyonları ticari kitler kullanılarak analiz edildi ve glukoz düzeyleri biyokimya cihazı ile ölçüldü. Nitrik oksit, BHBA ve NEFA konsantrasyonlarının en düşük kontrol grubunda, en yüksek ise klinik PT grubunda olduğu belirl grubunda bulundu. (P<0.001). Karunkular ve kotiledoner arterlere ait PI, RI, PSV, EDV ve A parametreleri açısından gruplar arasında anlamlı farklılıklar gözlendi (P<0.001). PI ve RI değerleri en yüksek kontrol grubunda, en düşük klinik PT grubunda belirlenirken (P<0.001); PSV, EDV ve A değerleri en düşük kontrol grubunda, en yüksek klinik PT grubunda belirlendi (P<0.001). Sonuç olarak, keçilerde gebelik toksemisinin plasental kan akımında önemli değişikliklere yol açtığı ve Doppler ultrasonografi parametrelerinin gebeliğin ileri dönemlerinde hastalığın tanısında değerli bir araç olabileceği belirlendi.

Abstract

The aim of the presented study was to determine the effects of pregnancy toxemia (PT) on placental blood flow in goats. The control group (n=15) consisted of goats with β-hydroxybutyric acid (BHBA) concentrations <0.8 mmol/L, the subclinical PT group (n=15) consisted of goats with BHBA concentrations between 0.8 and 1.6 mmol/L, and the clinical PT group (n=15) consisted of goats with BHBA concentrations between 1.6 and 5 mmol/L. Before any treatment or administration, caruncle and cotyledonary arteries were evaluated by Pulse Doppler ultrasonography (USG) in all goats. In addition, non-esterified fatty acid (NEFA) and nitric oxide (NO) concentrations were analyzed using commercial kits, and glucose levels were analyzed with a biochemistry device. Nitric oxide, BHBA and NEFA concentrations were lowest in the control group and highest in the clinical PT group (P<0.001). Glucose concentration was lowest in the clinical PT group and highest in the control group (P<0.001). Significant differences were observed between the groups in terms of PI, RI, PSV, EDV, and A values of the caruncle and cotyledonary arteries (P<0.001). PI and RI values were highest in the control group and lowest in the clinical PT group (P<0.001); while PSV, EDV, and A values were lowest in the control group and highest in the clinical PT group (P<0.001). In conclusion, it was determined that pregnancy toxemia in goats causes significant changes in placental blood flow, and Doppler ultrasonography parameters may be a valuable tool in diagnosing the disease in goats during the late stages of pregnancy.

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Bu Makaleye Atıf Yap

Yaprakcı, Ö., Akkuş, T. (2026). Gebelik Toksemisi Olan Keçilerde Plasentom Perfüzyonunun Değerlendirilmesi. Kocatepe Veteriner Dergisi, Cilt: 19 Sayı: 3, 404–414. https://doi.org/10.30607/kvj.1914313

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