Dergiler / Turkish Journal of Medical Sciences / 2015 / Cilt: 45 - Sayı: 3

Central corneal thickness in type II diabetes mellitus: is it relatedto the severity of diabetic retinopathy?

Sayfa
651–654
Yayın Tarihi
2015-08-13
DOI
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Retinal disease severity does not seem to have an effect on corneal thickness.

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Amaç & Hipotez:Background/aim: To compare the central corneal thickness (CCT) of type II diabetes mellitus patients with age- and sex-matched healthy subjects and to determine the association of the severity of diabetic retinopathy and CCT.
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Temel Bulgular & Veri:Results: The average CCT was significantly higher in diabetic patients than in the control group (P = 0.04).
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Sonuç & Katkı:Retinal disease severity does not seem to have an effect on corneal thickness.
🔬Tür:Araştırma Makalesi
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Central corneal thickness · diabetes mellitus · diabetic retinopathy

Özet

Background/aim: To compare the central corneal thickness (CCT) of type II diabetes mellitus patients with age- and sex-matched healthy subjects and to determine the association of the severity of diabetic retinopathy and CCT. Materials and methods: Type II diabetes mellitus patients without retinopathy, with nonproliferative retinopathy, and with proliferative retinopathy were organized as the three subgroups of the study group, and an age- and sex-matched control group was formed. All subjects underwent full ophthalmological examination and CCT measurement with ultrasonographic pachymetry. CCT values were compared between diabetic and healthy subjects and between the three diabetic subgroups. Correlation analysis was performed to determine any relationship between CCT and intraocular pressure. Results: The average CCT was significantly higher in diabetic patients than in the control group (P = 0.04). CCT in diabetic patients without retinopathy did not significantly differ from that of patients with retinopathy (P = 0.64). Similarly, there was no significant difference in CCT between nonproliferative and proliferative diabetic retinopathy patients (P = 0.47). In the whole study population, CCT was significantly correlated with intraocular pressure (P < 0.01). Conclusion: CCT is significantly increased in type II diabetes mellitus patients with respect to controls. Retinal disease severity does not seem to have an effect on corneal thickness.

Abstract

Background/aim: To compare the central corneal thickness (CCT) of type II diabetes mellitus patients with age- and sex-matched healthy subjects and to determine the association of the severity of diabetic retinopathy and CCT. Materials and methods: Type II diabetes mellitus patients without retinopathy, with nonproliferative retinopathy, and with proliferative retinopathy were organized as the three subgroups of the study group, and an age- and sex-matched control group was formed. All subjects underwent full ophthalmological examination and CCT measurement with ultrasonographic pachymetry. CCT values were compared between diabetic and healthy subjects and between the three diabetic subgroups. Correlation analysis was performed to determine any relationship between CCT and intraocular pressure. Results: The average CCT was significantly higher in diabetic patients than in the control group (P = 0.04). CCT in diabetic patients without retinopathy did not significantly differ from that of patients with retinopathy (P = 0.64). Similarly, there was no significant difference in CCT between nonproliferative and proliferative diabetic retinopathy patients (P = 0.47). In the whole study population, CCT was significantly correlated with intraocular pressure (P < 0.01). Conclusion: CCT is significantly increased in type II diabetes mellitus patients with respect to controls. Retinal disease severity does not seem to have an effect on corneal thickness.

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Bu Makaleye Atıf Yap

TOYGAR, O., SIZMAZ, S., PELİT, A., TOYGAR, B., KIZILOĞLU, Ö. Y., AKOVA, Y. (2015). Central corneal thickness in type II diabetes mellitus: is it relatedto the severity of diabetic retinopathy?. Turkish Journal of Medical Sciences, Cilt: 45 - Sayı: 3, 651–654. https://ajindex.com/articles/113954

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Kaynakça (12)

  1. Shetlar DJ, Bourne WM, Campbell RJ. Morphologic evaluation of Descemet’s membrane and corneal endothelium in diabetes mellitus. Ophthalmology 1989; 96: 247–250.
  2. Roszkowska AM, Tringali CG, Colosi P, Squeri CA, Ferreri G. Corneal endothelium evaluation in type I and type II diabetes mellitus. Ophthalmologica 1999; 213: 258–261.
  3. Rehany U, Ishii Y, Lahav M, Rumelt S. Ultrastructural changes in corneas of diabetic patients: an electron-microscopy study. Cornea 2000; 19: 534–538.
  4. Lee JS, Oum BS, Choi HY, Lee JE, Cho BM. Differences in corneal thickness and corneal endothelium related to duration in diabetes. Eye 2006; 20: 315–318.
  5. Goldich Y, Barkana Y, Gerber Y, Rasko A, Morad Y, Harstein M, Avni I, Zadok D. Effect of diabetes mellitus on biomechanical parameters of the cornea. J Cataract Refract Surg 2009; 35: 715–719.
  6. Harper CL, Boulton ME, Bennett D, Marcyniuk B, Jarvis- Evans JH, Tullo AB, Riddway AE. Diurnal variations in human corneal thickness. Br J Ophthalmol 1996; 80: 1068–1072.
  7. Sahin A, Bayer A, Ozge G, Mumcuoglu T. Corneal biomechanical changes in diabetes mellitus and their influence on intraocular pressure measurements. Invest Ophthal Vis Sci 2009; 50: 4597–4604. Early Treatment Diabetic Retinopathy Study Research Group. Fundus photographic risk factors for progression of diabetic retinopathy: ETDRS report number 12. Ophthalmology 1991; 98: 823–833. Early Treatment Diabetic Retinopathy Study Research Group. Fluorescein angiographic risk factors for progression of diabetic retinopathy: ETDRS report number 13. Ophthalmology 1991; 98: 834–840. Herse PR. Corneal hydration control in normal and alloxan- induced diabetic rabbits. Invest Ophthalmol Vis Sci 1990; 31: 2205–2213.
  8. Weston BC, Bourne WM, Polse KA, Hodge DO. Corneal hydration control in diabetes mellitus. Invest Ophthalmol Vis Sci 1995; 36: 586–595.
  9. Busted N, Olsen T, Schmitz O. Clinical observations on corneal thickness and the corneal endothelium in diabetes mellitus. Br J Ophthalmol 1981; 65: 687–690.
  10. Storr-Paulsen A, Singh A, Jeppesen H, Norregaard JC, Thulesen J. Corneal endothelial morphology and central retinal thickness in patients with type II diabetes mellitus. Acta Ophthalmol 2014; 92: 158–160.
  11. Ozdamar Y, Cankaya B, Ozalp S, Acaroglu G, Karakaya J, Ozkan SS. Is there a correlation between diabetes mellitus and central corneal thickness? J Glaucoma 2010; 19: 613–616.
  12. Su DH, Wong TY, Wong WL, Saw SM, Tan DT, Shen SY, Loon SC, Foster PJ, Aung T; Singapore Malay Eye Study Group. Diabetes,