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Dergiler / Turkish Journal of Medical Sciences / 2015 / Cilt: 45 - Sayı: 3

Serologic testing for celiac disease in young people with elevated transaminases

Juanli YUAN
Jinyan GAO
Yonghong YAO
Hongbing CHEN
Sayfa
668–673
Yayın Tarihi
2015-08-13
DOI
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Conclusion: Before the exclusion of every known cause of raised transaminase levels, routine serological screening for CD should not be recommended for patients who only present elevated transaminases.

📌 3 Maddede Bu Makale

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Amaç & Hipotez:Background/aim: A cryptogenic elevation of transaminases is the most common hepatic manifestation in celiac disease (CD).
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Temel Bulgular & Veri:In adult patients and pediatric patients with cryptogenic hypertransaminasemia, the prevalence of CD was 4% and 12%, respectively.
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Sonuç & Katkı:Conclusion: Before the exclusion of every known cause of raised transaminase levels, routine serological screening for CD should not be recommended for patients who only present elevated transaminases.
🔬Tür:Araştırma Makalesi
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Celiac disease · alanine aminotransferase · aspartate aminotransferases

Özet

Background/aim: A cryptogenic elevation of transaminases is the most common hepatic manifestation in celiac disease (CD). In adult patients and pediatric patients with cryptogenic hypertransaminasemia, the prevalence of CD was 4% and 12%, respectively. However, there are no related data from China in this regard. We aimed to investigate the status of CD in young Chinese patients with elevated transaminases. Materials and methods: A total of 125 patients with elevated transaminases and 125 healthy individuals as controls with matched age and sex were involved in the study. Serum markers of hepatitis B were determined in patients with elevated transaminases. All subjects were screened for CD by testing serum IgA antitissue transglutaminase antibodies (anti-tTG IgA), and total serum IgA was determined in order to rule out IgA deficiency. Results: None of the subjects were seropositive to IgA anti-tTG antibodies. No association between CD and elevated transaminases was found. Hepatitis B viral infections were one of the main causes of raised transaminases. Conclusion: Before the exclusion of every known cause of raised transaminase levels, routine serological screening for CD should not be recommended for patients who only present elevated transaminases.

Abstract

Background/aim: A cryptogenic elevation of transaminases is the most common hepatic manifestation in celiac disease (CD). In adult patients and pediatric patients with cryptogenic hypertransaminasemia, the prevalence of CD was 4% and 12%, respectively. However, there are no related data from China in this regard. We aimed to investigate the status of CD in young Chinese patients with elevated transaminases. Materials and methods: A total of 125 patients with elevated transaminases and 125 healthy individuals as controls with matched age and sex were involved in the study. Serum markers of hepatitis B were determined in patients with elevated transaminases. All subjects were screened for CD by testing serum IgA antitissue transglutaminase antibodies (anti-tTG IgA), and total serum IgA was determined in order to rule out IgA deficiency. Results: None of the subjects were seropositive to IgA anti-tTG antibodies. No association between CD and elevated transaminases was found. Hepatitis B viral infections were one of the main causes of raised transaminases. Conclusion: Before the exclusion of every known cause of raised transaminase levels, routine serological screening for CD should not be recommended for patients who only present elevated transaminases.

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Bu Makaleye Atıf Yap

YUAN, J., GAO, J., YAO, Y., CHEN, H. (2015). Serologic testing for celiac disease in young people with elevated transaminases. Turkish Journal of Medical Sciences, Cilt: 45 - Sayı: 3, 668–673. https://ajindex.com/articles/113942

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Kaynakça (16)

  1. Lammers KM, Vasagar B, Fasano A. Definition of celiac disease and gluten sensitivity. In: Devi Rampertab S, Mullin GE, editors. Celiac Disease. 1st ed. New York, NY, USA: Springer; 2014. pp. 13–25
  2. Green PH, Cellier C. Celiac disease. New Engl J Med 2007; 357: 1731–1743
  3. Zali MR, Nejad MR, Rostami K, Alavian SM. Liver complications in celiac disease. Hepat Mon 2011; 11: 333–341
  4. Volta U, Franceschi LD, Lari F, Molinaro N, Zoli M, Bianchi FB. Coeliac disease hidden by cryptogenic hypertransaminasaemia. Lancet 1998; 352: 26–29
  5. Vajro P, Paolella G, Maggiore G, Giordano G. Pediatric celiac disease, cryptogenic hypertransaminasemia, and autoimmune hepatitis. J Pediatr Gastr Nutr 2013; 56: 663–670
  6. Sainsbury A, Sanders DS, Ford A. Meta-analysis: coeliac disease and hypertransaminasaemia. Aliment Pharm Ther 2011; 34: 33–40
  7. Emami MH, Hashemi M, Kouhestani S, Taheri H, Karimi S. Should we look for celiac disease among all patients with liver function test abnormalities? Int J Prev Med 2012; 3: 167–172
  8. Ludvigsson JF, Biagi F, Corazza GR. Epidemiology of celiac disease. In: Devi Rampertab S, Mullin GE, editors. Celiac Disease. 1st ed. New York, NY, USA: Springer; 2014. pp. 27–37
  9. Cummins AG, Roberts-Thomson IC. Prevalence of celiac disease in the Asia–Pacific region. J Gastroen Hepatol 2009; 24: 1347–1351
  10. Yuan J, Gao J, Li X, Liu F, Wijmenga C, Chen H, Gilissen LJ. The tip of the “celiac iceberg” in China: a systematic review and meta-analysis. PLoS One 2013; 8: e81151
  11. Jiang L, Zhang B, Liu YS. Is adult celiac disease really uncommon in Chinese? J Zhejiang Univ Sci B 2009; 10: 168– 171
  12. Wang XQ, Liu W, Mei H, Gao Y, Peng HM, Yuan L, Xu JJ. Celiac disease in children with diarrhea in 4 cities in China. J Pediatr Gastr Nutr 2011; 53: 368–370
  13. Wu J, Xia B, von Blomberg B, Zhao C, Yang X, Crusius J, Peña A. Coeliac disease in China, a field waiting for exploration. Rev Esp Enferm Dig 2010; 102: 472–477
  14. Wang H, Luo L, Kou J, Yuan A, Yang G, Wang M, Xia B. Serum screening of celiac disease in Chinese adults with diarrheapredominant irritable bowel syndrome in Hubei, China. Zhonghua Nei Ke Zha Zi 2013; 52: 38–41 (in Chinese with abstract in English)
  15. Department of Disease Control Ministry of Health PC. Chinese Adult Overweight and Obesity Prevention and Control Guidelines. 1st ed. Beijing, China: People’s Medical Publishing House Co., Ltd; 2006 (in Chinese)
  16. Zhang Y, Weng X. Infectious Diseases. 4th ed. Shanghai,