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Dergiler / Turkish Journal of Medical Sciences / 2015 / Cilt: 45 - Sayı: 3

Relationship among MIF, MCP-1, viral loads, and HBs Ag levelsin chronic hepatitis B patients

Relationship among MIF, MCP-1, viral loads, and HBs Ag levels in chronic hepatitis B patients

HAYATİ GÜNEŞ
RAFET METE
MURAT AYDIN
BİROL TOPÇU
MUSTAFA ORAN
MUSTAFA DOĞAN
OĞUZHAN YILDIRIM
İLKNUR ERDEM
AYNUR EREN TOPKAYA
AHMET GÜREL
Sayfa
634–637
Yayın Tarihi
2015-08-13
DOI
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Yapay Zeka Hızlı Bakış & Çıkarımlar

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⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

More studies with a greater number of subjects are needed to evaluate the potential role of MIF and MCP in CAHB.

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Amaç & Hipotez:Background/aim: To determine whether macrophage migration inhibitory factor (MIF) and monocyte chemoattractant protein-1 (MCP-1) levels in patients with hepatitis B (HB) are different than in normal individuals and whether the HB surface antigen (HBs Ag) level and viral load are correlated with each other and with the two aforementioned parameters.
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Temel Bulgular & Veri:Materials and methods: Sera were obtained from 52 chronic active HB (CAHB) patients and 33 healthy controls, and their MIF and MCP-1 levels were measured.
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Sonuç & Katkı:More studies with a greater number of subjects are needed to evaluate the potential role of MIF and MCP in CAHB.
🔬Tür:Araştırma Makalesi
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Chronic active hepatitis B · macrophage migration inhibitory factor · monocyte chemoattractant protein-1

Özet

Background/aim: To determine whether macrophage migration inhibitory factor (MIF) and monocyte chemoattractant protein-1 (MCP-1) levels in patients with hepatitis B (HB) are different than in normal individuals and whether the HB surface antigen (HBs Ag) level and viral load are correlated with each other and with the two aforementioned parameters. Materials and methods: Sera were obtained from 52 chronic active HB (CAHB) patients and 33 healthy controls, and their MIF and MCP-1 levels were measured. Statistical analyses were performed. A value of P < 0.05 was considered statistically significant. Results: The MIF and MCP-1 values of the control group were increased compared to those of the CAHB group. The MIF and MCP-1 levels were negatively correlated with HBs Ag levels and viral loads. The MIF and MCP-1 levels were positively correlated. The HBs Ag levels and the log10 of the viral loads were positively correlated. Conclusion: We conclude that the negative correlation of MIF and MCP-1 with viral load and HBs Ag levels may be due to T-cell deficiency, antinuclear antibody seropositivity, and/or inhibition of chemokine ligand 2 receptors by viral antigens. More studies with a greater number of subjects are needed to evaluate the potential role of MIF and MCP in CAHB.

Abstract

Background/aim: To determine whether macrophage migration inhibitory factor (MIF) and monocyte chemoattractant protein-1 (MCP-1) levels in patients with hepatitis B (HB) are different than in normal individuals and whether the HB surface antigen (HBs Ag) level and viral load are correlated with each other and with the two aforementioned parameters. Materials and methods: Sera were obtained from 52 chronic active HB (CAHB) patients and 33 healthy controls, and their MIF and MCP-1 levels were measured. Statistical analyses were performed. A value of P < 0.05 was considered statistically significant. Results: The MIF and MCP-1 values of the control group were increased compared to those of the CAHB group. The MIF and MCP-1 levels were negatively correlated with HBs Ag levels and viral loads. The MIF and MCP-1 levels were positively correlated. The HBs Ag levels and the log10 of the viral loads were positively correlated. Conclusion: We conclude that the negative correlation of MIF and MCP-1 with viral load and HBs Ag levels may be due to T-cell deficiency, antinuclear antibody seropositivity, and/or inhibition of chemokine ligand 2 receptors by viral antigens. More studies with a greater number of subjects are needed to evaluate the potential role of MIF and MCP in CAHB.

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Bu Makaleye Atıf Yap

GÜNEŞ, H., METE, R., AYDIN, M., TOPÇU, B., ORAN, M., DOĞAN, M., YILDIRIM, O., ERDEM, İ., TOPKAYA, A. E., GÜREL, A. (2015). Relationship among MIF, MCP-1, viral loads, and HBs Ag levelsin chronic hepatitis B patients. Turkish Journal of Medical Sciences, Cilt: 45 - Sayı: 3, 634–637. https://ajindex.com/articles/113938

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