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Dergiler / Turkish Journal of Medical Sciences / 2018 / Cilt: 48 - Sayı: 6

Angiostatin levels in diabetes mellitus patients receiving insulin treatment: associations with laboratory findings, comorbidities, and medications

İsmail ERTÜRK
Erdim SERTOĞLU
Fatih YEŞİLDAL
Ramazan ACAR
Taner ÖZGÜRTAŞ
Kenan SAĞLAM
Sayfa
1192–1199
Yayın Tarihi
2018-12-12
DOI
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⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

Further studies are required to understand the effect of angiostatin in diabetics and the effect of medications on angiogenesis in these patients.

📌 3 Maddede Bu Makale

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Amaç & Hipotez:Background/aim: The clinical effect of angiostatin in diabetes mellitus (DM) patients receiving insulin is a meaningful gap in the literature.
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Temel Bulgular & Veri:A total of 83 people consisting of healthy subjects (n = 36) and patients with a diagnosis of DM receiving insulin therapy (n = 47) were included in this study.
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Sonuç & Katkı:Further studies are required to understand the effect of angiostatin in diabetics and the effect of medications on angiogenesis in these patients.
🔬Tür:Araştırma Makalesi
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Diabetes mellitus · angiostatin · insulin

Abstract

Background/aim: The clinical effect of angiostatin in diabetes mellitus (DM) patients receiving insulin is a meaningful gap in the literature. In this study, we aimed to show the levels and the clinical significance of angiostatin in DM patients receiving insulin. Materials and methods: This is a case-control study. Serum angiostatin levels were determined by ELISA. A total of 83 people consisting of healthy subjects (n = 36) and patients with a diagnosis of DM receiving insulin therapy (n = 47) were included in this study. Results: The mean angiostatin levels of the DM group were significantly higher than those of the control group (86.0 ± 68.1 ng/mL and 58.0 ± 22.4 ng/mL, respectively; P = 0.011). Significantly lower angiostatin levels were determined in the DM patients receiving metformin with respect to those not receiving metformin (97.2 ± 74.4 ng/mL and 49.3 ± 7.0 ng/mL, respectively; P = 0.021). Significantly higher levels of angiostatin were observed among the DM patients using a beta-blocker (BB) than the DM patients not using a BB (115.5 ± 78.71 ng/mL and 73.44 ± 60.08 ng/mL, respectively; p = 0.029). Conclusion: This is the first study evaluating and demonstrating the serum angiostatin levels in DM patients receiving insulin. Further studies are required to understand the effect of angiostatin in diabetics and the effect of medications on angiogenesis in these patients.

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Bu Makaleye Atıf Yap

ERTÜRK, İ., SERTOĞLU, E., YEŞİLDAL, F., ACAR, R., ÖZGÜRTAŞ, T., SAĞLAM, K. (2018). Angiostatin levels in diabetes mellitus patients receiving insulin treatment: associations with laboratory findings, comorbidities, and medications. Turkish Journal of Medical Sciences, Cilt: 48 - Sayı: 6, 1192–1199. https://ajindex.com/articles/113849

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Kaynakça (7)

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