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Dergiler / Turkish Journal of Medical Sciences / 2018 / Cilt: 48 - Sayı: 6

The diagnostic role of pentraxin-3 in the differential diagnosis of pleural effusions

Fatma ÇİFTCİ
Gülden BİLGİN
Ayşe Naz ÖZCAN
Özlem DOĞAN
Aycan YÜKSEL
Serhat EROL
Aydın ÇİLEDAĞ
Akın KAYA
Sayfa
1167–1174
Yayın Tarihi
2018-12-12
DOI
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⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

These results may suggest that PTX-3 is a local acute-phase reactant and may allow discrimination of PPE from other exudative effusions.

📌 3 Maddede Bu Makale

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Amaç & Hipotez:Background/aim: Discrimination of pleural effusion etiology is not always easy in clinical practice.
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Temel Bulgular & Veri:Pentraxin-3 (PTX-3) is a new acute- phase protein.
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Sonuç & Katkı:These results may suggest that PTX-3 is a local acute-phase reactant and may allow discrimination of PPE from other exudative effusions.
🔬Tür:Araştırma Makalesi
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Pleural effusion · pentraxin-3 · transudates

Abstract

Background/aim: Discrimination of pleural effusion etiology is not always easy in clinical practice. Pentraxin-3 (PTX-3) is a new acute- phase protein. The aim of this study was to investigate the role of PTX-3 in the differential diagnosis of pleural effusions. Materials and methods: This prospective study enrolled all consecutive patients from two tertiary hospitals who underwent diagnostic or therapeutic thoracentesis. In a cohort of 149 subjects with pleural effusion, including transudates and malignant (MPE), tuberculous (TPE), and parapneumonic effusion (PPE), serum and pleural effusion PTX-3 concentration measurements were performed using ELISA. Serum and pleural effusion protein, lactate dehydrogenase, C-reactive protein (CRP), and adenosine deaminase levels were also assessed. Results: Of these patients, 34 had transudates, 29 had PPE, 63 had MPE, and 23 had TPE. There was a weak correlation between pleural effusion PTX-3 level and serum CRP (P < 0.01). There was a significant difference in pleural PTX-3 levels between the exudative effusion groups (P < 0.01). The median pleural effusion PTX-3 was significantly higher in patients with PPE (11.2 ng/mL, 2-17.8) than MPE (4.7 ng/mL, 1.8-13.9) and TPE (3.1 ng/mL, 2.0-4.1). At a cut-off point of 5.89 ng/mL, PTX-3 had the best discriminatory power for PPE versus other exudative effusions (sensitivity: 86.2%, specificity: 87.7%). The exudative effusion group had a significantly different pleural effusion/serum PTX-3 ratio (P = 0.03). Conclusion: PTX-3 concentration in pleural effusion was elevated without a significant correlation with serum PTX-3 in PPE. These results may suggest that PTX-3 is a local acute-phase reactant and may allow discrimination of PPE from other exudative effusions.

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Bu Makaleye Atıf Yap

ÇİFTCİ, F., BİLGİN, G., ÖZCAN, A. N., DOĞAN, Ö., YÜKSEL, A., EROL, S., ÇİLEDAĞ, A., KAYA, A. (2018). The diagnostic role of pentraxin-3 in the differential diagnosis of pleural effusions. Turkish Journal of Medical Sciences, Cilt: 48 - Sayı: 6, 1167–1174. https://ajindex.com/articles/113843

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