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Dergiler / İstanbul Tıp Fakültesi Dergisi / 2026 / Cilt: 84 Sayı: 3

ANNE SÜTÜNDE SARS-COV-2 ANTİJENİ VE ANTİKORU

SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS-2 ANTIGENS AND ANTIBODIES IN BREAST MILK

Gonca Keskindemirci(İstanbul University İstanbul Medical Faculty Department of Pediatrics Division of Social Pediatrics)0000-0003-1797-2802
Nalan Karabayır(İSTANBUL MEDİPOL ÜNİVERSİTESİ, ULUSLARARASI TIP FAKÜLTESİ, DAHİLİ TIP BİLİMLERİ BÖLÜMÜ, ÇOCUK SAĞLIĞI VE HASTALIKLARI ANABİLİM DALI, SOSYAL PEDİATRİ BİLİM DALI)0000-0002-8003-1952
Ayşe İstanbullu(İSTANBUL MEDİPOL ÜNİVERSİTESİ, TIP FAKÜLTESİ, TEMEL TIP BİLİMLERİ BÖLÜMÜ, TIBBİ MİKROBİYOLOJİ ANABİLİM DALI)0000-0003-3952-1914
Selda Hançerli Törün(İstanbul University İstanbul Medical Faculty Department of Pediatrics Division of Child Infection Diseases)0000-0002-3216-2413
Ceren Altay(İSTANBUL MEDİPOL UNİVERSİTY MEDİCAL FACULTY DEPARTMENT OF PEDİATRİCS)0000-0002-5439-192X
Muhammet Fatih Sebirli(İstanbul Medipol University Medical Faculty Department of Pediatrics)0000-0001-6465-0449
Özge Kaba(İstanbul University İstanbul Medical Faculty Department of Pediatrics Division of Child Infection Diseases)0000-0002-8381-3255
Büşra Sultan Kibar(Yalova Goverment Hospital)0000-0002-6535-1034
Gülbin Gökçay(İstanbul University Child Health Insitute Department of Social Pediatrics)0000-0003-1042-0407
Sayfa
287–292
Yayın Tarihi
2021-07-31
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⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

Bulgular: Nazofarengeal sürüntüde SARS-CoV-2 PCR testleri 11 annenin 10’unda pozitifti.

📌 3 Maddede Bu Makale

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Amaç & Hipotez:Amaç: Koronavirüs hastalığı-19 (COVID-19) tanısı almış annelerin anne sütünde Şiddetli Akut Solunum Sendromu koronavirüs-2 (SARS-CoV-2) antijeni ile IgM ve IgG antikorlarının belirlenmesi amaçlanmıştır.
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Temel Bulgular & Veri:Gereç ve Yöntem: Çalışma 11 anne-çocuk çifti ile gerçekleştirildi.
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Sonuç & Katkı:Bulgular: Nazofarengeal sürüntüde SARS-CoV-2 PCR testleri 11 annenin 10’unda pozitifti.
🔬Tür:Araştırma Makalesi
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Anne sütü · COVID-19 · emzirme

Özet

Amaç: Koronavirüs hastalığı-19 (COVID-19) tanısı almış annelerin anne sütünde Şiddetli Akut Solunum Sendromu koronavirüs-2 (SARS-CoV-2) antijeni ile IgM ve IgG antikorlarının belirlenmesi amaçlanmıştır. Gereç ve Yöntem: Çalışma 11 anne-çocuk çifti ile gerçekleştirildi. Çalışmaya PCR testine göre pozitif olan veya negatif olup ancak COVID semptomları olan emziren anneler dahil edildi. Sağılmış anne sütü, analiz aşamasına kadar -20/-80°C’de saklandı. Anne sütü SARS-CoV-2 antijeni ve IgM ve IgG antikorları ölçüldü. Bebekler en az 15 gün takip edildi. Bulgular: Nazofarengeal sürüntüde SARS-CoV-2 PCR testleri 11 annenin 10’unda pozitifti. Dokuz annede COVID-19 semptomları vardı. Annelerin semptomlarından veya pozitif PCR sonuçlarından ortalama 15 gün sonra anne sütü örneği alındı. Nazofarengeal sürüntü testlerinde SARS-CoV-2 PCR testleri 11 anne bebeğinin 7’sinde pozitifti. SARS-CoV-2 antijeni hiçbir annenin anne sütünde saptanmadı. Ancak PCR testi pozitif olan ve klinik semptomlar yaşayan iki annenin sütünde SARS-CoV-2 IgG ve IgM antikorları tespit edildi. Bu iki annenin çocukları hiçbir belirti göstermedi. Sonuç: SARS-CoV-2 salgınında resmi kurumlar tarafından emzirme tavsiye edilmiş ve desteklenmiştir. Bulgularımız bu öneriyi desteklemektedir. Emzirmenin acil koşullarda teşviki ve korunması, çocuğun, annenin ve toplumun sağlığı açısından çok önemlidir.

Abstract

Objective: This study aimed to determine the presence of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) antigens and IgM and IgG antibodies in breast milk of mothers diagnosed with Coronavirus disease-19 (COVID-19). Methods: The study was conducted in 11 mother-child pairs. Breastfeeding mothers who were either positive according to a PCR test or those who were negative but had COVID symptoms were included in the study. Expressed milk was stored at -20/-80°C until analysis. Breastmilk SARS-CoV-2 antigens and IgM and IgG antibodies were measured. The infants were followed for at least 15 days. Results: SARS-CoV-2 PCR tests using a nasopharyngeal swab was positive in 10 of 11 mothers. Nine mothers had symptoms of COVID-19. Breast milk samples were taken, on average, 15 days after symptom onset or a positive PCR result. SARS-CoV-2 PCR tests using a nasopharyngeal swab was positive in seven infants. The SARS-CoV-2 antigen was not detected in the breast milk of any of the mothers. However, SARS-CoV-2 IgG and IgM antibodies were detected in the breast milk of two mothers, who had a positive PCR test and experienced clinical symptoms. The children of these two mothers experienced no symptoms. Conclusion: Official institutions have recommended and supported breastfeeding during the SARS-CoV-2 pandemic. Our findings support this recommendation. The promotion and protection of breastfeeding under emergency conditions is of great importance for the health of children, mothers, and society.

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Bu Makaleye Atıf Yap

Keskindemirci, G., Karabayır, N., İstanbullu, A., Törün, S. H., Altay, C., Sebirli, M. F., Kaba, Ö., Kibar, B. S., Gökçay, G. (2021). ANNE SÜTÜNDE SARS-COV-2 ANTİJENİ VE ANTİKORU. İstanbul Tıp Fakültesi Dergisi, Cilt: 84 Sayı: 3, 287–292. https://doi.org/10.26650/IUITFD.2021.928835

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