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Dergiler / İstanbul Tıp Fakültesi Dergisi / 2026 / Cilt: 89 Sayı: 2

THE OBESITY PARADOX IN THE COEXISTENCE OF DIABETES AND CORONARY ARTERY DISEASE

Mehmet Aydoğan(İSTANBUL ÜNİVERSİTESİ, İSTANBUL TIP FAKÜLTESİ)0000-0003-1342-3590
Mustafa Lütfi Yavuz(İSTANBUL ÜNİVERSİTESİ, İSTANBUL TIP FAKÜLTESİ)0000-0002-4082-7518
Naci Şenkal(İSTANBUL ÜNİVERSİTESİ, İSTANBUL TIP FAKÜLTESİ)0000-0001-7072-8724
Pelin Karaca Özer(İSTANBUL ÜNİVERSİTESİ, İSTANBUL TIP FAKÜLTESİ)0000-0002-1085-5462
Samim Emet(İSTANBUL ÜNİVERSİTESİ, İSTANBUL TIP FAKÜLTESİ)0000-0002-2806-4335
Murat Kose(İSTANBUL ÜNİVERSİTESİ, İSTANBUL TIP FAKÜLTESİ)0000-0002-7487-9287
Tufan Tükek(İSTANBUL ÜNİVERSİTESİ, İSTANBUL TIP FAKÜLTESİ)0000-0002-4237-1163
Sayfa
123–126
Yayın Tarihi
2026-05-13
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Conclusion: Among diabetic patients, those who were obese had significantly less extensive and severe CAD compared to their non-obese counterparts, supporting the concept of the obesity paradox.

📌 3 Maddede Bu Makale

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Amaç & Hipotez:Objective: Although obesity is a well-established risk factor for coronary artery disease (CAD), several recent studies have paradoxically demonstrated lower cardiovascular mortality rates among obese individuals.
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Temel Bulgular & Veri:Materials and Methods: A total of 1,557 patients who underwent coronary angiography were retrospectively screened.
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Sonuç & Katkı:Conclusion: Among diabetic patients, those who were obese had significantly less extensive and severe CAD compared to their non-obese counterparts, supporting the concept of the obesity paradox.
🔬Tür:Klinik Araştırma
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Obesity · Coronary Artery Disease · Obesity Paradox

Abstract

Objective: Although obesity is a well-established risk factor for coronary artery disease (CAD), several recent studies have paradoxically demonstrated lower cardiovascular mortality rates among obese individuals. This study aimed to compare the extent of CAD between obese and non-obese diabetic patients and evaluate the presence of the obesity paradox in this population. Materials and Methods: A total of 1,557 patients who underwent coronary angiography were retrospectively screened. Fifty-three diabetic patients were included and divided into two groups according to body mass index (BMI): ≥30 and <30. The groups were matched for age, gender, and other cardiovascular risk factors. The extent of CAD was assessed using the SYNTAX score. Statistical analyses were performed using IBM SPSS Statistics version 27, and a p-value of <0.05 was considered statistically significant. Results: There were no statistically significant differences between the groups (BMI ≥30 vs. <30) regarding age, gender, HbA1c, LDL, total cholesterol, creatinine levels, hypertension, family history, atrial fibrillation, cerebrovascular disease, and smoking status. The SYNTAX score was significantly lower in the obese group (12.67±9.68) compared to the non-obese group (19±12.68) (p=0.046). Conclusion: Among diabetic patients, those who were obese had significantly less extensive and severe CAD compared to their non-obese counterparts, supporting the concept of the obesity paradox.

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Bu Makaleye Atıf Yap

Aydoğan, M., Yavuz, M. L., Şenkal, N., Özer, P. K., Emet, S., Kose, M., Tükek, T. (2026). THE OBESITY PARADOX IN THE COEXISTENCE OF DIABETES AND CORONARY ARTERY DISEASE. İstanbul Tıp Fakültesi Dergisi, Cilt: 89 Sayı: 2, 123–126. https://doi.org/10.26650/IUITFD.1721723

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