Dergiler / Gıda / 2024 / Cilt: 49 Sayı: 6

ALTERNATİF PROTEİN KAYNAĞI OLARAK MAKROALGLER VE MAKROALGAL PROTEİNLERİN EKSTRAKSİYONU: BİR DERLEME ÇALIŞMASI

MACROALGAE AS ALTERNATIVE PROTEIN SOURCES AND EXTRACTION OF MACROALGAL PROTEIN: A REVIEW STUDY

Eda Şensu(Istanbul Gelisim University)0000-0002-6240-8381
Aysun Yücetepe(AKSARAY ÜNİVERSİTESİ)0000-0002-3800-4774
Beraat Özçelik(İSTANBUL TEKNİK ÜNİVERSİTESİ)0000-0002-1810-8154
Dergi
Gıda
Sayfa
1175–1189
Yayın Tarihi
2024-12-09
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⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

Ayrıca, makroalglerden proteinlerin ekstraksiyonu için enzimatik, darbeli elektrik alan, ultrases, mikrodalga, yüksek basınç ve sub-kritik akışkan ekstraksiyon gibi yeni yöntemler tartışılmıştır.

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Amaç & Hipotez:Nüfus artışı, ekilebilir arazi ve su kaynaklarının giderek azalması ve hayvancılığın olumsuz çevresel etkisi alternatif protein kaynaklarını bulma konusunda araştırma yapmayı gerekli kılmaktadır.
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Temel Bulgular & Veri:Ancak, makroalglerden protein ekstraksiyonu için kullanılan geleneksel yöntemler yüksek enerji ve su tüketiminin yanı sıra düşük ekstraksiyon verimi nedeniyle dezavantajlar sunmaktadır ve bu da makroalgal proteinlerin kullanılabilirliğini sınırlamaktadır.
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Sonuç & Katkı:Ayrıca, makroalglerden proteinlerin ekstraksiyonu için enzimatik, darbeli elektrik alan, ultrases, mikrodalga, yüksek basınç ve sub-kritik akışkan ekstraksiyon gibi yeni yöntemler tartışılmıştır.
🔬Tür:Literatür & Derleme Çalışması
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Makroalg · deniz yosunu · protein

Özet

Nüfus artışı, ekilebilir arazi ve su kaynaklarının giderek azalması ve hayvancılığın olumsuz çevresel etkisi alternatif protein kaynaklarını bulma konusunda araştırma yapmayı gerekli kılmaktadır. Biyoaktif bileşenler açısından zengin olan makroalgler potansiyel sağlık yararları nedeni ile ilgi çekmektedir. Makroalgler, ekilebilir araziye ihtiyaç duymadan yetiştirilebilmeleri nedeni ile karasal bitkilere göre önemli bir avantaja sahiptir. Ayrıca, makroalgler diğer bitkisel ve hayvansal kaynaklı proteinlere kıyasla protein ve amino asit içeriği açısından önemli ölçüde zengindir. Ancak, makroalglerden protein ekstraksiyonu için kullanılan geleneksel yöntemler yüksek enerji ve su tüketiminin yanı sıra düşük ekstraksiyon verimi nedeniyle dezavantajlar sunmaktadır ve bu da makroalgal proteinlerin kullanılabilirliğini sınırlamaktadır. Bu noktada, makroalglerden proteinlerin ekstraksiyonu için düşük maliyetli, yeni ve sürdürülebilir teknolojilere ihtiyaç duyulmaktadır. Bu derleme çalışmasında, öncelikle makroalglerin özellikleri, protein kalitesi, amino asit bileşimi ve sindirilebilirliğine dayalı olarak kullanım potansiyelleri açıklanmıştır. Ayrıca, makroalglerden proteinlerin ekstraksiyonu için enzimatik, darbeli elektrik alan, ultrases, mikrodalga, yüksek basınç ve sub-kritik akışkan ekstraksiyon gibi yeni yöntemler tartışılmıştır.

Abstract

ncreased population, decrease in arable land and water supplies, and the detrimental environmental impact of husbandry have prompted research into alternate protein sources. Macroalgae, rich in bioactive chemicals, are gaining popularity due to their potential health advantages. Macroalgae have a significant advantage over terrestrial plants in that they can be cultivated without needing arable land. In addition, macroalgae are significantly rich in protein and amino acid content compared to other plant and animal proteins. However, traditional methods used for protein extraction from macroalgae present disadvantages due to high energy and water consumption and low extraction efficiency, which limits the usability of macroalgal proteins. At this point, protein extraction from macroalgae requires low-cost, innovative, and sustainable technology. This review indicates the properties of macroalgae and their potential for use based on their protein quality, amino acid composition and digestibility. Also, new methods such as enzymatic, pulsed electric field, ultrasound, high pressure, and sub-critic water extraction for extracting proteins from macroalgae were discussed.

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Bu Makaleye Atıf Yap

Şensu, E., Yücetepe, A., Özçelik, B. (2024). ALTERNATİF PROTEİN KAYNAĞI OLARAK MAKROALGLER VE MAKROALGAL PROTEİNLERİN EKSTRAKSİYONU: BİR DERLEME ÇALIŞMASI. Gıda, Cilt: 49 Sayı: 6, 1175–1189. https://doi.org/10.15237/gida.GD24093

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Kaynakça (81)

  1. Agrawal, S. B., Gupta, N., Bhagyawant, S. S., Gaikwad, S. M. (2020). Anticancer Activity of Lectins from Bauhinia purpurea and Wisteria floribunda on Breast Cancer MCF-7 Cell Lines. Protein and Peptide Letters, 27(9), 870–877. https://doi.org/10.2174/0929866527666200408143614
  2. Ahmed, M. N., Jahan, R., Nissapatorn, V., Wilairatana, P., Rahmatullah, M. (2022). Plant lectins as prospective antiviral biomolecules in the search for COVID-19 eradication strategies. Biomedecine & Pharmacotherapie, 146(112507), 112507. https://doi.org/10.1016/ j.biopha.2021.112507
  3. Bashir, N., Sood, M., Bandral, J. D. (2020). Enzyme immobilization and its applications in food processing: A review. Int. J. Chem. Stud, 8(2), 254–261. https://www.academia.edu/ download/83065850/8-1-503-295.pdf
  4. Bhadange, Y. A., Carpenter, J., Saharan, V. K. (2024). A comprehensive review on advanced extraction techniques for retrieving bioactive components from natural sources. ACS Omega, 9(29), 31274–31297. https://doi.org/10.1021/ acsomega.4c02718
  5. Biris-Dorhoi, E.-S., Michiu, D., Pop, C. R., Rotar, A. M., Tofana, M., Pop, O. L., Socaci, S. A., Farcas, A. C. (2020). Macroalgae-A sustainable source of chemical compounds with biological activities. Nutrients, 12(10), 3085. https://doi.org/ 10.3390/nu12103085
  6. Bleakley, S., Hayes, M. (2017). Algal Proteins: Extraction, Application, and Challenges Concerning Production. Foods (Basel, Switzerland), 6(5). https://doi.org/10.3390/foods6050033
  7. Bringloe, T. T., Starko, S., Wade, R. M., Vieira, C., Kawai, H., De Clerck, O., Cock, J. M., Coelho, S. M., Destombe, C., Valero, M., Neiva, J., Pearson, G. A., Faugeron, S., Serrão, E. A., Verbruggen, H. (2020). Phylogeny and evolution of the brown algae. Critical Reviews in Plant Sciences, 39(4), 281–321. https://doi.org/10.1080/ 07352689.2020.1787679
  8. Cai, J., Lovatelli, A., Aguilar-Manjarrez, J., Cornish, L., Dabbadie, L., Desrochers, A., Diffey, S., Garrido Gamarro, E., Geehan, J., Hurtado, A., Lucente, D., Mair, G., Miao, W., Potin, P., Przybyla, C., Reantaso, M., Roubach, R., Tauati, M., Yuan, X. (2021). Seaweeds and microalgae: An overview for unlocking their potential in global aquaculture development (Food and Agriculture Organization, Ed.). Food & Agriculture Organization of the UN. https://doi.org/10.4060/cb5670en
  9. Cermeño, M., Kleekayai, T., Amigo-Benavent, M., Harnedy-Rothwell, P., FitzGerald, R. J. (2020). Current knowledge on the extraction, purification, identification, and validation of bioactive peptides from seaweed. Electrophoresis, 41(20), 1694–1717. https://doi.org/10.1002/ elps.202000153
  10. Cheng, Y., Xue, F., Yu, S., Du, S., Yang, Y. (2021). Subcritical Water Extraction of Natural Products. Molecules, 26(13). https://doi.org/10.3390/ molecules26134004
  11. Christou, A., Stavrou, I. J., Kapnissi-Christodoulou, C. P. (2021). Continuous and pulsed ultrasound-assisted extraction of carob’s antioxidants: Processing parameters optimization and identification of polyphenolic composition. Ultrasonics Sonochemistry, 76(105630), 105630. https://doi.org/10.1016/j.ultsonch.2021.105630
  12. Circuncisão, A. R., Catarino, M. D., Cardoso, S. M., Silva, A. M. S. (2018). Minerals from Macroalgae Origin: Health Benefits and Risks for Consumers. Marine Drugs, 16(11). https://doi.org/10.3390/md16110400
  13. Corino, C., Modina, S. C., Di Giancamillo, A., Chiapparini, S., Rossi, R. (2019). Seaweeds in pig nutrition. Animals: An Open Access Journal from MDPI, 9(12), 1126. https://doi.org/10.3390/ ani9121126
  14. Corrales, M., Toepfl, S., Butz, P., Knorr, D., Tauscher, B. (2008). Extraction of anthocyanins from grape by-products assisted by ultrasonics, high hydrostatic pressure or pulsed electric fields: A comparison. Innovative Food Science & Emerging Technologies: IFSET: The Official Scientific Journal of the European Federation of Food Science and Technology, 9(1), 85–91. https://doi.org/10.1016/ j.ifset.2007.06.002
  15. Cotas, J., Leandro, A., Pacheco, D., Gonçalves, A. M. M., Pereira, L. (2020). A comprehensive review of the nutraceutical and therapeutic applications of red seaweeds (Rhodophyta). Life (Basel, Switzerland), 10(3), 19. https://doi.org/ 10.3390/life10030019
  16. de Souza Celente, G., Sui, Y., Acharya, P. (2023). Seaweed as an alternative protein source: Prospective protein extraction technologies. Innovative Food Science & Emerging Technologies: IFSET: The Official Scientific Journal of the European Federation of Food Science and Technology, 86(103374), 103374. https://doi.org/10.1016/ j.ifset.2023.103374
  17. Di Domenico Ziero, H., Buller, L. S., Mudhoo, A., Ampese, L. C., Mussatto, S. I., Carneiro, T. F. (2020). An overview of subcritical and supercritical water treatment of different biomasses for protein and amino acids production and recovery. Journal of Environmental Chemical Engineering, 8(5), 104406. https://doi.org/10.1016/j.jece.2020.104406
  18. Domozych, D. (2019). Algal Cell Walls. In eLS (pp. 1–11). John Wiley & Sons, Ltd. https://doi.org/10.1002/9780470015902.a0000315.pub4
  19. Dopelt, K., Radon, P., Davidovitch, N. (2019). Environmental Effects of the Livestock Industry: The Relationship between Knowledge, Attitudes, and Behavior among Students in Israel. International Journal of Environmental Research and Public Health, 16(8). https://doi.org/10.3390/ ijerph16081359
  20. Echave, J., Fraga-Corral, M., Garcia-Perez, P., Popović-Djordjević, J., H Avdović, E., Radulović, M., Xiao, J., A Prieto, M., Simal-Gandara, J. (2021). Seaweed Protein Hydrolysates and Bioactive Peptides: Extraction, Purification, and Applications. Marine Drugs, 19(9). https://doi.org/10.3390/md19090500
  21. Echave, J., Otero, P., Garcia-Oliveira, P., Munekata, P. E. S., Pateiro, M., Lorenzo, J. M., Simal-Gandara, J., Prieto, M. A. (2022). Seaweed-derived proteins and peptides: Promising marine bioactives. Antioxidants (Basel, Switzerland), 11(1), 176. https://doi.org/10.3390/antiox11010176
  22. Fao, F. (2018). The State of World Fisheries and Aquaculture 2018-Meeting the sustainable development goals. Food and Agriculture Organization of the United Nations.
  23. Fasolin, L. H., Pereira, R. N., Pinheiro, A. C., Martins, J. T., Andrade, C. C. P., Ramos, O. L., Vicente, A. A. (2019). Emergent food proteins - Towards sustainability, health and innovation. Food Research International, 125(108586), 108586. https://doi.org/10.1016/j.foodres.2019.108586
  24. Ferdouse, F., Løvstad Holdt, S., Smith, R., Murúa, P., Yang, L. (2018). The global status of seaweed production, trade and utilization. Globefish Research Programme Volume 124. https://policycommons.net/artifacts/2242866/the-global-status-of-seaweed-production-trade-and-utilization/3000967/
  25. Garcia-Vaquero, M., Ummat, V., Tiwari, B., Rajauria, G. (2020). Exploring Ultrasound, Microwave and Ultrasound–Microwave Assisted Extraction Technologies to Increase the Extraction of Bioactive Compounds and Antioxidants from Brown Macroalgae. Marine Drugs, 18(3), 172. https://doi.org/10.3390/ md18030172
  26. Gaspar, R., Fonseca, R., Pereira, L. (2020). Illustrated Guide to the Macroalgae of Buarcos Bay, Figueira da Foz, Portugal. MARE UC, DCV, FCT.
  27. Gomez-Zavaglia, A., Prieto Lage, M. A., Jimenez-Lopez, C., Mejuto, J. C., Simal-Gandara, J. (2019). The Potential of Seaweeds as a Source of Functional Ingredients of Prebiotic and Antioxidant Value. Antioxidants (Basel, Switzerland), 8(9). https://doi.org/10.3390/antiox8090406
  28. Gordalina, M., Pinheiro, H. M., Mateus, M., da Fonseca, M. M. R., Cesário, M. T. (2021). Macroalgae as protein sources—A review on protein bioactivity, extraction, purification and characterization. Applied Sciences (Basel, Switzerland), 11(17), 7969. https://doi.org/ 10.3390/app11177969
  29. Grosso, C., Valentão, P., Ferreres, F., Andrade, P. B. (2015). Alternative and efficient extraction methods for marine-derived compounds. Marine Drugs, 13(5), 3182–3230. https://doi.org/ 10.3390/md13053182
  30. Harnedy, P. A., FitzGerald, R. J. (2011). Bioactive proteins, peptides, and amino acids from macroalgae(1). Journal of Phycology, 47(2), 218–232. https://doi.org/10.1111/j.1529-8817.2011.00969.x
  31. Harnedy, P. A., FitzGerald, R. J. (2013). Extraction of protein from the macroalga Palmaria palmata. LWT - Food Science and Technology, 51(1), 375–382. https://doi.org/ 10.1016/j.lwt.2012.09.023
  32. Ho, C. H. L., Cacace, J. E., Mazza, G. (2007). Extraction of lignans, proteins and carbohydrates from flaxseed meal with pressurized low polarity water. LWT - Food Science and Technology, 40(9), 1637–1647. https://doi.org/10.1016/ j.lwt.2006.12.003
  33. Ji, L., Qiu, S., Wang, Z., Zhao, C., Tang, B., Gao, Z., Fan, J. (2023). Phycobiliproteins from algae: Current updates in sustainable production and applications in food and health. Food Research International, 167, 112737. https://doi.org/ 10.1016/j.foodres.2023.112737
  34. Joannes, C., Sipaut, C. S., Dayou, J., Mansa, R. F. (2015). The potential of using pulsed electric field (PEF) technology as the cell disruption method to extract lipid from microalgae for biodiesel production. International Journal of Renewable Energy Research, 5(2), 598–621. https://dergipark.org.tr/ en/pub/ijrer/issue/16071/167979
  35. Kadam, S., Álvarez, C., Tiwari, B., O’Donnell, C. (2015). Extraction of biomolecules from seaweeds. Seaweed Sustainability, 243–269. https://doi.org/10.1016/B978-0-12-418697-2.00009-X
  36. Kamal, M., Abdel-Raouf, N., Alwutayd, K., AbdElgawad, H., Abdelhameed, M. S., Hammouda, O., Elsayed, K. N. M. (2023). Seasonal changes in the biochemical composition of dominant macroalgal species along the Egyptian Red Sea shore. Biology, 12(3), 411. https://doi.org/10.3390/biology12030411
  37. Kazir, M., Abuhassira, Y., Robin, A., Nahor, O., Luo, J., Israel, A., Golberg, A., Livney, Y. D. (2019). Extraction of proteins from two marine macroalgae, Ulva sp. and Gracilaria sp., for food application, and evaluating digestibility, amino acid composition and antioxidant properties of the protein concentrates. Food Hydrocolloids, 87, 194–203.
  38. Konstantin, B., Anastasia, P., Nikolay, I., Daria, P. (2023). Seasonal variations in the chemical composition of Arctic brown macroalgae. Algal Research, 72(103112), 103112. https://doi.org/10.1016/j.algal.2023.103112
  39. Lakshmi, D. S., Sankaranarayanan, S., Gajaria, T. K., Li, G., Kujawski, W., Kujawa, J., Navia, R. (2020). A Short Review on the Valorization of Green Seaweeds and Ulvan: FEEDSTOCK for Chemicals and Biomaterials. Biomolecules, 10(7). https://doi.org/10.3390/biom10070991
  40. Machado, M., Machado, S., Pimentel, F. B., Freitas, V., Alves, R. C., Oliveira, M. B. P. P. (2020). Amino acid profile and protein quality assessment of macroalgae produced in an integrated multi-trophic aquaculture system. Foods (Basel, Switzerland), 9(10), 1382. https://doi.org/10.3390/foods9101382
  41. Magpusao, J., Oey, I., Kebede, B. (2021). Opportunities and challenges of algal protein extraction and production.
  42. Meng, W., Mu, T., Sun, H., Garcia-Vaquero, M. (2022). Evaluation of the chemical composition and nutritional potential of brown macroalgae commercialised in China. Algal Research, 64, 102683. https://doi.org/10.1016/ j.algal.2022.102683
  43. Mittal, R., Tavanandi, H. A., Mantri, V. A., Raghavarao, K. S. M. S. (2017). Ultrasound assisted methods for enhanced extraction of phycobiliproteins from marine macro-algae, Gelidium pusillum (Rhodophyta). Ultrasonics Sonochemistry, 38, 92–103. https://doi.org/ 10.1016/j.ultsonch.2017.02.030
  44. Nadathur, S., Wanasundara, J. P. D., Scanlin, L. (2024). Feeding the globe nutritious food in 2050: Obligations and ethical choices. In S. Nadathur, J. P. D. Wanasundara, & L. Scanlin (Eds.), Sustainable Protein Sources (pp. 649–668). Elsevier. https://doi.org/10.1016/b978-0-323-91652-3.00032-0
  45. Nan, F., Feng, J., Lv, J., Liu, Q., Fang, K., Gong, C., Xie, S. (2017). Origin and evolutionary history of freshwater Rhodophyta: further insights based on phylogenomic evidence. Scientific Reports, 7(1), 2934. https://doi.org/10.1038/s41598-017-03235-5
  46. Naseri, A., Marinho, G. S., Holdt, S. L., Bartela, J. M., Jacobsen, C. (2020). Enzyme-assisted extraction and characterization of protein from red seaweed Palmaria palmata. Algal Research, 47, 101849. https://doi.org/10.1016/ j.algal.2020.101849
  47. O’ Brien, R., Hayes, M., Sheldrake, G., Tiwari, B., Walsh, P. (2022). Macroalgal Proteins: A Review. Foods (Basel, Switzerland), 11(4). https://doi.org/ 10.3390/foods11040571
  48. O’ Connor, J., Meaney, S., Williams, G. A., Hayes, M. (2020). Extraction of protein from four different seaweeds using three different physical pre-treatment strategies. Molecules (Basel, Switzerland), 25(8), 2005. https://doi.org/ 10.3390/molecules25082005
  49. O’Connor, J., Garcia-Vaquero, M., Meaney, S., Tiwari, B. K. (2022). Bioactive Peptides from Algae: Traditional and Novel Generation Strategies, Structure-Function Relationships, and Bioinformatics as Predictive Tools for Bioactivity. Marine Drugs, 20(5). https://doi.org/10.3390/ md20050317
  50. Okolie, C. L., Akanbi, T. O., Mason, B., Udenigwe, C. C., Aryee, A. N. A. (2019). Influence of conventional and recent extraction technologies on physicochemical properties of bioactive macromolecules from natural sources: A review. Food Research International (Ottawa, Ont.), 116, 827–839. https://doi.org/10.1016/ j.foodres.2018.09.018
  51. Paiva, L., Lima, E., Patarra, R. F., Neto, A. I., Baptista, J. (2014). Edible Azorean macroalgae as source of rich nutrients with impact on human health. Food Chemistry, 164, 128–135. https://doi.org/10.1016/j.foodchem.2014.04.119
  52. Pangestuti, R., Getachew, A. T., Siahaan, E. A., Chun, B.-S. (2019). Characterization of functional materials derived from tropical red seaweed Hypnea musciformis produced by subcritical water extraction systems. Journal of Applied Phycology, 31(4), 2517–2528. https://doi.org/ 10.1007/s10811-019-1754-9
  53. Pan-Utai, W., Pantoa, T., Roytrakul, S., Praiboon, J., Kosawatpat, P., Tamtin, M., Thongdang, B. (2022). Ultrasonic-assisted extraction and antioxidant potential of valuable protein from Ulva rigida macroalgae. Life (Basel, Switzerland), 13(1), 86. https://doi.org/10.3390/life13010086
  54. Peñalver, R., Lorenzo, J. M., Ros, G., Amarowicz, R., Pateiro, M., Nieto, G. (2020). Seaweeds as a functional ingredient for a healthy diet. Marine Drugs, 18(6), 301. https://doi.org/10.3390/ md18060301 Pereira, L. (2021a). Edible seaweeds of the world. CRC Press.
  55. Pereira, L. (2021b). Macroalgae. Encyclopedia, 1(1), 177–188. https://doi.org/10.3390/ encyclopedia1010017
  56. Pimentel, F. B., Alves, R. C., Harnedy, P. A., FitzGerald, R. J., Oliveira, M. B. P. P. (2019). Macroalgal-derived protein hydrolysates and bioactive peptides: Enzymatic release and potential health enhancing properties. Trends in Food Science & Technology, 93, 106–124. https://doi.org/10.1016/j.tifs.2019.09.006
  57. Plaza, M., Amigo-Benavent, M., del Castillo, M. D., Ibáñez, E., Herrero, M. (2010). Facts about the formation of new antioxidants in natural samples after subcritical water extraction. Food Research International, 43(10), 2341–2348. https://doi.org/10.1016/j.foodres.2010.07.036
  58. Pliego-Cortés, H., Wijesekara, I., Lang, M., Bourgougnon, N., Bedoux, G. (2020). Chapter Nine - Current knowledge and challenges in extraction, characterization and bioactivity of seaweed protein and seaweed-derived proteins. In N. Bourgougnon (Ed.), Advances in Botanical Research (Vol. 95, pp. 289–326). Academic Press. https://doi.org/10.1016/bs.abr.2019.11.008
  59. Polikovsky, M., Fernand, F., Sack, M., Frey, W., Müller, G., Golberg, A. (2019). In silico food allergenic risk evaluation of proteins extracted from macroalgae Ulva sp. with pulsed electric fields. Food Chemistry, 276, 735–744. https://doi.org/10.1016/j.foodchem.2018.09.134
  60. Postma, P. R., Cerezo-Chinarro, O., Akkerman, R. J., Olivieri, G., Wijffels, R. H., Brandenburg, W. A., Eppink, M. H. M. (2018). Biorefinery of the macroalgae Ulva lactuca: extraction of proteins and carbohydrates by mild disintegration. Journal of Applied Phycology, 30(2), 1281–1293. https://doi.org/10.1007/s10811-017-1319-8
  61. Prabhu, M. S., Levkov, K., Livney, Y. D., Israel, A., Golberg, A. (2019). High-voltage pulsed electric field preprocessing enhances extraction of starch, proteins, and ash from marine macroalgae Ulva ohnoi. ACS Sustainable Chemistry & Engineering, 7(20), 17453–17463. https://doi.org/10.1021/ acssuschemeng.9b04669
  62. Praveen, M. A., Parvathy, K. R. K., Balasubramanian, P., Jayabalan, R. (2019). An overview of extraction and purification techniques of seaweed dietary fibers for immunomodulation on gut microbiota. Trends in Food Science & Technology, 92, 46–64. https://doi.org/10.1016/j.tifs.2019.08.011
  63. Puzorjov, A., McCormick, A. J. (2020). Phycobiliproteins from extreme environments and their potential applications. Journal of Experimental Botany, 71(13), 3827–3842. https://doi.org/10.1093/jxb/eraa139
  64. Qu, W., Ma, H., Wang, T., Zheng, H. (2013). Alternating two-frequency countercurrent ultrasonic-assisted extraction of protein and polysaccharide from Porphyra yezoensis. Transactions of the Chinese Society of Agricultural Engineering/Nongye Gongcheng Xuebao, 29(1), 285–292.
  65. Rawiwan, P., Peng, Y., Paramayuda, I. G. P. B., Quek, S. Y. (2022). Red seaweed: A promising alternative protein source for global food sustainability. Trends in Food Science & Technology, 123, 37–56. https://doi.org/10.1016/ j.tifs.2022.03.003
  66. Robin, A., Kazir, M., Sack, M., Israel, A., Frey, W., Mueller, G., Livney, Y. D., Golberg, A. (2018). Functional protein concentrates extracted from the Green marine macroalga Ulva sp., by high voltage pulsed electric fields and mechanical press. ACS Sustainable Chemistry & Engineering, 6(11), 13696–13705. https://doi.org/10.1021/ acssuschemeng.8b01089
  67. Ruslan, F. S., Susanti, D., Mohammad Noor, N., Aminudin, N. I. (2021). Bioactive Compounds, Cosmeceutical And Nutraceutical Applications of Green Seaweed Species (Chlorophyta). SQUALEN Bulletin of Marine and Fisheries Postharvest and Biotechnology, 16(1), 41–55. https://doi.org/10.15578/squalen.514
  68. Salehi, B., Sharifi-Rad, J., Seca, A. M. L., Pinto, D. C. G. A., Michalak, I., Trincone, A., Mishra, A. P., Nigam, M., Zam, W., Martins, N. (2019). Current Trends on Seaweeds: Looking at Chemical Composition, Phytopharmacology, and Cosmetic Applications. Molecules, 24(22). https://doi.org/ 10.3390/molecules24224182
  69. Samarathunga, J., Wijesekara, I., Jayasinghe, M. (2022). Seaweed proteins as a novel protein alternative: Types, extractions, and functional food applications. Food Reviews International, 1–26. https://doi.org/10.1080/87559129.2021.2023564
  70. Silva, A., Silva, S. A., Lourenço-Lopes, C., Jimenez-Lopez, C., Carpena, M., Gullón, P., Fraga-Corral, M., Domingues, V. F., Barroso, M. F., Simal-Gandara, J., Prieto, M. A. (2020). Antibacterial use of macroalgae compounds against foodborne pathogens. Antibiotics (Basel, Switzerland), 9(10), 712. https://doi.org/10.3390/ antibiotics9100712
  71. Suwal, S., Perreault, V., Marciniak, A., Tamigneaux, É., Deslandes, É., Bazinet, L., Jacques, H., Beaulieu, L., Doyen, A. (2019). Effects of high hydrostatic pressure and polysaccharidases on the extraction of antioxidant compounds from red macroalgae, Palmaria palmata and Solieria chordalis. Journal of Food Engineering, 252, 53–59. https://doi.org/ 10.1016/j.jfoodeng.2019.02.014
  72. Thiviya, P., Gamage, A., Gama-Arachchige, N. S., Merah, O., Madhujith, T. (2022). Seaweeds as a source of functional proteins. Phycology, 2(2), 216–243. https://doi.org/10.3390/phycology2020012
  73. Tibbetts, S. M., Milley, J. E., Lall, S. P. (2016). Nutritional quality of some wild and cultivated seaweeds: Nutrient composition, total phenolic content and in vitro digestibility. Journal of Applied Phycology, 28(6), 3575–3585. https://doi.org/ 10.1007/s10811-016-0863-y
  74. Titlyanov, E. A., Titlyanova, T. V. (2010). Seaweed cultivation: Methods and problems. Russian Journal of Marine Biology, 36(4), 227–242. https://doi.org/10.1134/S1063074010040012
  75. Vásquez, V., Martínez, R., Bernal, C. (2019). Enzyme-assisted extraction of proteins from the seaweeds Macrocystis pyrifera and Chondracanthus chamissoi: characterization of the extracts and their bioactive potential. Journal of Applied Phycology, 31(3), 1999–2010. https://doi.org/10.1007/s10811-018-1712-y
  76. Vázquez-Rodríguez, B., Gutiérrez-Uribe, J. A., Antunes-Ricardo, M., Santos-Zea, L., Cruz-Suárez, L. E. (2020). Ultrasound-assisted extraction of phlorotannins and polysaccharides from Silvetia compressa (Phaeophyceae). Journal of Applied Phycology, 32(2), 1441–1453. https://doi.org/10.1007/s10811-019-02013-2
  77. Xi, J. (2017). Ultrahigh pressure extraction of bioactive compounds from plants-A review. Critical Reviews in Food Science and Nutrition, 57(6), 1097–1106. https://doi.org/10.1080/ 10408398.2013.874327
  78. Xie, C., Lee, Z. J., Ye, S., Barrow, C. J., Dunshea, F. R., Suleria, H. A. R. (2024). A review on seaweeds and seaweed-derived polysaccharides: Nutrition, chemistry, bioactivities, and applications. Food Reviews International, 40(5), 1312–1347. https://doi.org/10.1080/ 87559129.2023.2212055
  79. Yücetepe, A., Aydar, E. F., Dogu-Baykut, E., Dinç, H., Onat, İ. A., Demircan, E., Şensu, E., Okudan, E. Ş., Özçelik, B. (2024). Optimization of protein extraction from Halopteris scoparia macroalgae by ultrasonic-assisted enzymatic extraction (UAEE): Bioactive, chemical, and technological properties. ACS Food Science & Technology, 4(6), 1375–1387. https://doi.org/ 10.1021/acsfoodscitech.4c00032
  80. Zainan, N. H., Sapardi, M. A. M., Ho, B. C. H., Siajam, S. I., Kamal, S. M. M., Danquah, M. K., Harun, R. (2022). Kinetic and thermodynamic characterization of amino acids generation via subcritical water reaction of microalgae Nannochloropsis sp. biomass. Biomass Conversion and Biorefinery, 12(6), 2001–2014. https://doi.org/ 10.1007/s13399-019-00538-7
  81. Plaza, M., Amigo-Benavent, M., del Castillo, M. D., Ibáñez, E., Herrero, M. (2010). Facts about the formation of new antioxidants in natural samples after subcritical water extraction. Food Research International, 43(10), 2341–2348. https://doi.org/10.1016/j.foodres.2010.07.036