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Dergiler / Ankara Üniversitesi Eczacılık Fakültesi Dergisi / 2026 / Cilt: 47 Sayı: 2

HYPERICUM SCABRUM L. EKSTRESİNİN ANTİOKSİDAN, ENZİM İNHİBİTÖR AKTİVİTESİNİN DEĞERLENDİRİLMESİ VE YPSK ANALİZİ

EVALUATION OF ANTIOXIDANT, ENZYME INHIBITOR ACTIVITY OF HYPERICUM SCABRUM EXTRACT AND HPLC ANALYSIS

Hasya Nazlı Gök(Gazi University)0000-0003-4115-7509
Semih Bulut(GAZI UNIVERSITY)0000-0002-4098-0221
Didem Deliorman Orhan(GAZI UNIVERSITY)0000-0003-3916-4048
Sayfa
349–359
Yayın Tarihi
2023-05-20
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⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

Araştırma kapsamında H. scabrum bitkisinin toprak üstü kısımlarından hazırlanan etanol (%80) ekstresinin, antioksidan, antidiyabetik, anti-obezite, antikolesterol aktiviteleri ile fitokimyasal içeriğinin incelenmesi amaçlanmıştır.

📌 3 Maddede Bu Makale

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Amaç & Hipotez:Amaç: Diyabet ve obezite günümüzün en yaygın sağlık problemleri arasında yer almaktadır.
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Temel Bulgular & Veri:Bu problemlerin tedavisi için yeni ilaç kaynaklarına ihtiyaç duyulmaktadır.
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Sonuç & Katkı:Araştırma kapsamında H. scabrum bitkisinin toprak üstü kısımlarından hazırlanan etanol (%80) ekstresinin, antioksidan, antidiyabetik, anti-obezite, antikolesterol aktiviteleri ile fitokimyasal içeriğinin incelenmesi amaçlanmıştır.
🔬Tür:Araştırma Makalesi
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Antidiyabetik · antihiperlipidemik · antioksidan

Özet

Amaç: Diyabet ve obezite günümüzün en yaygın sağlık problemleri arasında yer almaktadır. Bu problemlerin tedavisi için yeni ilaç kaynaklarına ihtiyaç duyulmaktadır. Toplumda geleneksel olarak kullanımı ile bilinen Hypericum scabrum L. bitkisi bu araştırmanın konusu olmuştur. Araştırma kapsamında H. scabrum bitkisinin toprak üstü kısımlarından hazırlanan etanol (%80) ekstresinin, antioksidan, antidiyabetik, anti-obezite, antikolesterol aktiviteleri ile fitokimyasal içeriğinin incelenmesi amaçlanmıştır.

Abstract

Objective: Diabetes and obesity are among the most common health problems today. New drug sources are needed to treat these problems. Hypericum scabrum L. , which is known for its traditional use among the public, has been the subject of this research. Within the scope of the research, it was aimed to investigate the antioxidant, antidiabetic, anti-obesity, anticholesterol activities, and phytochemical content of ethanol (80%) extract prepared from the aerial parts of the H. scabrum.

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Bu Makaleye Atıf Yap

Gök, H. N., Bulut, S., Orhan, D. D. (2023). HYPERICUM SCABRUM L. EKSTRESİNİN ANTİOKSİDAN, ENZİM İNHİBİTÖR AKTİVİTESİNİN DEĞERLENDİRİLMESİ VE YPSK ANALİZİ. Ankara Üniversitesi Eczacılık Fakültesi Dergisi, Cilt: 47 Sayı: 2, 349–359. https://doi.org/10.33483/jfpau.1128840

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Kaynakça (33)

  1. Boles, A., Kandimalla, R., Reddy, P.H. (2017). Dynamics of diabetes and obesity: Epidemiological perspective. Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease, 1863(5), 1026-1036. [CrossRef]
  2. Al-Goblan, A.S., Al-Alfi, M.A., Khan, M.Z. (2014). Mechanism linking diabetes mellitus and obesity. Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy, 7, 587-591. [CrossRef]
  3. Simonen, P.P., Gylling, H.K., Miettinen, T.A. (2002). Diabetes contributes to cholesterol metabolism regardless of obesity. Diabetes Care, 25(9), 1511-1515. [CrossRef]
  4. Rahimi, R., Nikfar, S., Larijani, B., Abdollahi, M. (2005). A review on the role of antioxidants in the management of diabetes and its complications. Biomedicine Pharmacotherapy, 59(7), 365-373. [CrossRef]
  5. Sharopov, F.S., Gulmurodov, I.S., Setzer, W.N. (2010). Essential oil composition of Hypericum perforatum L. and Hypericum scabrum L. growing wild in Tajikistan. Journal of Chemical and Pharmaceutical Research, 2(6), 284-290.
  6. Jiang, L., Numonov, S., Bobakulov, K., Qureshi, M.N., Zhao, H., Aisa, H.A. (2015). Phytochemical profiling and evaluation of pharmacological activities of Hypericum scabrum L. Molecules, 20(6), 11257-11271. [CrossRef]
  7. Eslami, B., Nabavi, S.F., Nabavi, S.M., Ebrahimzadeh, M.A., Mahmoudi, M. (2011). Pharmacological activities of Hypericum scabrum L. European Review for Medical and Pharmacological Sciences, 15(5), 32-37.
  8. Baytop T (1999): Therapy with Medicinal Plants in Turkey; Today and in Future. Istanbul, Istanbul University Press, pp. 166– 167.
  9. Davis, P.H. (1970). Flora of Turkey and the East Aegean Islands. Vol. 3. Flora of Turkey and the East Aegean Islands. Vol. 3.
  10. Tatli A (1988): Important Range Plants of Erzurum Province. Ankara, Turkey, Food and Agricultural Organization of the United Nations Press, pp. 1–77
  11. Pirbalouti, A.G., Rahnama, G.H., Malekpoor, F., Broujeni, H.R. (2011). Variation in antibacterial activity and phenolic content of Hypericum scabrum L. populations. Journal of Medicinal Plants Research, 5(17), 4119-4125.
  12. Özen, H.Ç., Başhan, M. (2003). The composition of fatty acids in Hypericum scabrum, H. scabroides and H. amblysepalum. Turkish Journal of Chemistry, 27(6), 723-726.
  13. Matsuhisa, M., Shikishima, Y., Takaishi, Y., Honda, G., Ito, M., Takeda, Y., Shibata, H., Higuti, T., Kodzhimatov, O.K., Ashurmetov, O. (2002). Benzoylphloroglucinol Derivatives from Hypericum scabrum. Journal of Natural Products, 65(3), 290-294. [CrossRef]
  14. Ayan, A.K., Radušienė, J., Çirak, C., Ivanauskas, L., Janulis, V. (2009). Secondary metabolites of Hypericum scabrum and Hypericum bupleuroides. Pharmaceutical Biology, 47(9), 847-853. [CrossRef]
  15. Tanker, N. (1971). Studies on Hypericum scabrum L. Journal of Faculty of Pharmacy of Ankara University, 1(1), 10-15.
  16. Dalar, A. (2018). Plant taxa used in the treatment of diabetes in Van Province, Turkey. International Journal of Secondary Metabolite, 5(3), 171-185. [CrossRef]
  17. Edirs, S., Jiang, L., Xin, X., Aisa, H.A. (2018). Anti-diabetic effect and mechanism of Kursi Wufarikun Ziyabit in L6 rat skeletal muscle cells. Journal of Pharmacological Sciences, 137(2), 212-219. [CrossRef]
  18. Barış, D., Kızıl, M., Aytekin, Ç., Kızıl, G., Yavuz, M., Çeken, B., Ertekin, A. S. (2011). In vitro antimicrobial and antioxidant activity of ethanol extract of three Hypericum and three Achillea species from Turkey. International Journal of Food Properties, 14(2), 339-355. [CrossRef]
  19. Zongo, C., Savadogo, A., Ouattara, L., Bassole, I. H.N., Ouattara, C.A.T., Ouattara, A.S., Barro, N., Koudou, J., Traore, A.S. (2010). Polyphenols content, antioxidant and antimicrobial activities of Ampelocissus grantii (Baker) Planch. (Vitaceae): a medicinal plant from Burkina Faso. International Journal of Pharmacology, 6(6), 880-887. [CrossRef]
  20. Kosalec, I., Bakmaz, M., Pepeljnjak, S., Vladimir-Knezevic, S. (2004). Quantitative analysis of the flavonoids in raw propolis from northern Croatia. Acta Pharmaceutica, 54(1), 65-72.
  21. Jung, H.A., Jin, S.E., Choi, R.J., Manh, H.T., Kim, Y.S., Min, B.S., Son, Y.K, Ahn, B.R., Kim, B.W. Sohn, H.S., Choi, J.S. (2011). Anti-tumorigenic activity of sophoflavescenol against Lewis lung carcinoma in vitro and in vivo. Archives of Pharmacal Research, 34(12), 2087-2099. [CrossRef]
  22. Dinis, T.C., Madeira, V.M., Almeida, L.M. (1994). Action of phenolic derivatives (acetaminophen, salicylate, and 5-aminosalicylate) as inhibitors of membrane lipid peroxidation and as peroxyl radical scavengers. Archives of Biochemistry and Biophysics, 315(1), 161-169. [CrossRef]
  23. Orhan, N., Orhan, D.D., Gökbulut, A., Aslan, M., Ergun, F. (2017). Comparative analysis of chemical profile, antioxidant, in-vitro and in-vivo antidiabetic activities of Juniperus foetidissima Willd. and Juniperus sabina L. Iranian Journal of Pharmaceutical Research: IJPR, 16(Suppl), 64-74.
  24. Prieto, P., Pineda, M., Aguilar, M. (1999). Spectrophotometric quantitation of antioxidant capacity through the formation of a phosphomolybdenum complex: specific application to the determination of vitamin E. Analytical Biochemistry, 269(2), 337-341. [CrossRef]
  25. Lam, S.H., Chen, J.M., Kang, C.J., Chen, C.H., Lee, S.S. (2008). α-Glucosidase inhibitors from the seeds of Syagrus romanzoffiana. Phytochemistry, 69(5), 1173-1178. [CrossRef]
  26. Ali, H., Houghton, P.J., Soumyanath, A. (2006). α-Amylase inhibitory activity of some Malaysian plants used to treat diabetes; with particular reference to Phyllanthus amarus. Journal of Ethnopharmacology, 107(3), 449-455. [CrossRef]
  27. Lee, Y.M., Kim, Y.S., Lee, Y., Kim, J., Sun, H., Kim, J.H., Kim, J.S. (2012). Inhibitory activities of pancreatic lipase and phosphodiesterase from Korean medicinal plant extracts. Phytotherapy Research, 26(5), 778-782. [CrossRef]
  28. Ngamukote, S., Mäkynen, K., Thilawech, T., Adisakwattana, S. (2011). Cholesterol-lowering activity of the major polyphenols in grape seed. Molecules, 16(6), 5054-5061. [CrossRef]
  29. Seyrekoglu, F., Temiz, H., Eser, F., Yildirim, C. (2022). Comparison of the antioxidant activities and major constituents of three Hypericum species (H. perforatum, H. scabrum and H. origanifolium) from Turkey. South African Journal of Botany, 146, 723-727. [CrossRef]
  30. Ayan, A.K., Çırak, C., Güney, K. (2008). Seasonal variation of hypericin and pseudohypericin contents in Hypericum scabrum L. growing wild in Turkey. Natural Product Communications, 3(2), 241-244. [CrossRef]
  31. Zarei, M.A., Tahazadeh, H. (2019). Alpha-glucosidase inhibitory activity in methanol extract of some plants from Kurdistan province. Journal of Medicinal Plants, 18(72), 227-235. [CrossRef]
  32. Llorent-Martínez, E.J., Zengin, G., Lobine, D., Molina-García, L., Mollica, A., Mahomoodally, M.F. (2018). Phytochemical characterization, in vitro and in silico approaches for three Hypericum species. New Journal of Chemistry, 42(7), 5204-5214. [CrossRef]
  33. Faraji, N., Ganji, A., Heshami, N., Salehi, I., Haddadian, A., Shojaie, S., Komaki, A. (2021). Hypolipidemic effects of Hypericum scabrum extract on the serum lipid profile and obesity in high-fat diet fed rats. Human Antibodies, 29(1), 55-61. [CrossRef]