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DİYABET TEDAVİSİNDE GLUKOZA DUYARLI HİDROJELLER

GLUCOSE-SENSITIVE HYDROGELS IN THE TREATMENT OF DIABETES

Ahmet Uyar(AĞRI İBRAHİM ÇEÇEN ÜNİVERSİTESİ, ECZACILIK FAKÜLTESİ)0000-0003-4292-1644
Burcu Devrim Gökberk(ANKARA ÜNİVERSİTESİ, ECZACILIK FAKÜLTESİ)0000-0002-9238-259X
Sayfa
175–190
Yayın Tarihi
2026-01-16
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⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

Bir açma kapama mekanizmasıyla insülin salımını ayarlayabilen bu hidrojeller, diyabet tedavisinde hastaların kan glukozunu yönetme potansiyeline sahiptirler.

📌 3 Maddede Bu Makale

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Amaç & Hipotez:Amaç: Bu derlemede, insüline bağımlı diyabet hastalarının tedavisi için hazırlanmış glukoza duyarlı hidrojeller sınıflandırılarak tanıtılması amaçlanmıştır.
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Temel Bulgular & Veri:Çeşitli glukoza duyarlı malzemelerden hazırlanan bu hidrojellerin insülin salım mekanizmaları ve diyabet tedavisindeki etkinlikleri üzerine odaklanılmıştır.
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Sonuç & Katkı:Bir açma kapama mekanizmasıyla insülin salımını ayarlayabilen bu hidrojeller, diyabet tedavisinde hastaların kan glukozunu yönetme potansiyeline sahiptirler.
🔬Tür:Literatür & Derleme Çalışması
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Diyabet · glukoza duyarlı hidrojel · insülin

Özet

Amaç: Bu derlemede, insüline bağımlı diyabet hastalarının tedavisi için hazırlanmış glukoza duyarlı hidrojeller sınıflandırılarak tanıtılması amaçlanmıştır. Çeşitli glukoza duyarlı malzemelerden hazırlanan bu hidrojellerin insülin salım mekanizmaları ve diyabet tedavisindeki etkinlikleri üzerine odaklanılmıştır. Sonuç ve Tartışma: İnsüline bağımlı diyabet hastalarına ihtiyaç anında ve yeterli miktarda insülin verilmelidir. Aksi takdirde, kan glukoz seviyeleri normal aralıkta tutulamayan hastada çeşitli komplikasyonlar ortaya çıkar. Pankreasın kan glukoz konsantrasyonuna bağımlı insülin salım profillerini taklit edebilen terapötik sistemlerin geliştirilmesi için glukoza duyarlı malzemeler olan glukoz oksidaz (GOx), konkanavalin A (Con A) veya fenilboronik asit (PBA) hidrojellere entegre edilebilir. Glukoza duyarlı malzeme içeren hidrojeller, diyabetik hastanın değişen kan glukoz seviyelerine yanıt verebilirler. Diyabet tedavisi için hastaya farklı yollarla uygulanabilecek glukoza duyarlı makro, mikro ve nano boyutlarda hidrojeller ve kompozit hidrojeller hazırlanmıştır. Bir açma kapama mekanizmasıyla insülin salımını ayarlayabilen bu hidrojeller, diyabet tedavisinde hastaların kan glukozunu yönetme potansiyeline sahiptirler.

Abstract

Objective: In this review, it is aimed to classify and introduce glucose-sensitive hydrogels prepared for the treatment of insulin-dependent diabetes patients. The insulin release mechanisms of these hydrogels prepared from various glucose-sensitive materials and their efficacy in diabetes treatment are focused on. Result and Discussion: Insulin dependent diabetes patients should be given sufficient amount of insulin when needed. Otherwise, various complications occur in the patient whose blood glucose levels cannot be kept within the normal range. Glucose-sensitive materials, glucose oxidase, concanavalin A, or phenylboronic acid can be integrated into hydrogels to develop therapeutic systems that can mimic the blood glucose concentration-dependent insulin release profiles of the pancreas. Hydrogels containing glucose-sensitive material can respond to the changing blood glucose levels of the diabetic patient. Glucose-sensitive macro, micro and nano-sized hydrogels and composite hydrogels that can be administered to patients in different ways for diabetes treatment have been prepared. These hydrogels, which can regulate insulin release with an on-off mechanism, have the potential to manage blood glucose in patients in the treatment of diabetes.

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Bu Makaleye Atıf Yap

Uyar, A., Gökberk, B. D. (2026). DİYABET TEDAVİSİNDE GLUKOZA DUYARLI HİDROJELLER. Ankara Üniversitesi Eczacılık Fakültesi Dergisi, Cilt: 50 Sayı: 1, 175–190. https://doi.org/10.33483/jfpau.1583693

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Kaynakça (83)

  1. Aloke, C., Egwu, C.O., Aja, P.M., et al. (2022). Current advances in the management of diabetes mellitus. Biomedicines, 10(10), 2436. [CrossRef]
  2. Banday, M.Z., Sameer, A.S., Nissar, S. (2020). Pathophysiology of diabetes: An overview. Avicenna Journal of Medicine, 10(4), 174-188. [CrossRef]
  3. Hossain, M.J., Al-Mamun, M., Islam, M.R. (2024). Diabetes mellitus, the fastest growing global public health concern: Early detection should be focused. Health Science Reports, 7(3), e2004. [CrossRef]
  4. Lin, X., Xu, Y., Pan, X., et al. (2020). Global, regional, and national burden and trend of diabetes in 195 countries and territories: An analysis from 1990 to 2025. Scientific Reports, 10(1), 14790. [CrossRef]
  5. Meneguin, A.B., Silvestre, A.L.P., Sposito, L., et al. (2021). The role of polysaccharides from natural resources to design oral insulin micro- and nanoparticles intended for the treatment of diabetes mellitus: A review. Carbohydrate Polymers, 256, 117504. [CrossRef]
  6. Cryer, P.E. (2007). Hypoglycemia, functional brain failure, and brain death. The Journal of Clinical Investigation, 117(4), 868-870. [CrossRef]
  7. Shen, D., Yu, H., Wang, L., et al. (2020). Recent progress in design and preparation of glucose-responsive insulin delivery systems. Journal of Controlled Release, 321, 236-258. [CrossRef]
  8. Sharma, A.K., Taneja, G., Kumar, A., et al. (2019). Insulin analogs: Glimpse on contemporary facts and future prospective. Life Sciences, 219, 90-99. [CrossRef]
  9. Miyata, T., Uragami, T., Nakamae, K. (2002). Biomolecule-sensitive hydrogels. Advanced Drug Delivery Reviews, 54(1), 79-98. [CrossRef]
  10. Jo, S.M., Lee, H.Y., Kim, J.C. (2009). Glucose-sensitivity of liposomes incorporating conjugates of glucose oxidase and poly(N-isopropylacrylamide-co-methacrylic acid-co-octadecylacrylate). International Journal of Biological Macromolecules, 45(4), 421-426. [CrossRef]
  11. Wu, J.Z., Williams, G.R., Li, H.Y., et al. (2017). Insulin-loaded PLGA microspheres for glucose-responsive release. Drug Delivery, 24(1), 1513-1525. [CrossRef]
  12. Gaballa, H., Theato, P. (2019). Glucose-responsive polymeric micelles via boronic acid-diol complexation for insulin delivery at neutral pH. Biomacromolecules, 20(2), 871-881. [CrossRef]
  13. Wang, C., Ye, Y., Sun, W., et al. (2017). Red blood cells for glucose-responsive insulin delivery. Advanced Materials, 29(18), 1606617. [CrossRef]
  14. Yu, J., Wang, Q., Liu, H., et al. (2020). Glucose-responsive microspheres as a smart drug delivery system for controlled release of insulin. European Journal of Drug Metabolism and Pharmacokinetics, 45(1), 113-121. [CrossRef]
  15. Mansoor, S., Kondiah, P.P.D., Choonara, Y.E. (2021). Advanced hydrogels for the controlled delivery of insulin. Pharmaceutics, 13(12), 2113. [CrossRef]
  16. Fu, Z., Gilbert, E.R., Liu, D. (2013). Regulation of insulin synthesis and secretion and pancreatic beta-cell dysfunction in diabetes. Current Diabetes Reviews, 9(1), 25-53. [CrossRef]
  17. Padhi, S., Nayak, A.K., Behera, A. (2020). Type II diabetes mellitus: A review on recent drug based therapeutics. Biomedicine and Pharmacotherapy, 131, 110708. [CrossRef]
  18. Ng, L.C., Gupta, M. (2020). Transdermal drug delivery systems in diabetes management: A review. Asian Journal of Pharmaceutical Sciences, 15(1), 13-25. [CrossRef]
  19. Alejandro, E.U., Mamerto, T.P., Chung, G., et al. (2020). Gestational diabetes mellitus: A harbinger of the vicious cycle of diabetes. International Journal of Molecular Sciences, 21(14), 5003. [CrossRef]
  20. Thrasher, J. (2017). Pharmacologic management of type 2 diabetes mellitus: Available therapies. The American Journal of Cardiology, 120(1S), S4-S16. [CrossRef]
  21. Mears, D. (2004). Regulation of insulin secretion in islets of Langerhans by Ca(2+)channels. The Journal of Membrane Biology, 200(2), 57-66. [CrossRef]
  22. Kramer, C.K., Retnakaran, R., Zinman, B. (2021). Insulin and insulin analogs as antidiabetic therapy: A perspective from clinical trials. Cell Metabolism, 33(4), 740-747. [CrossRef]
  23. Zhu, Q., Chen, Z., Paul, P.K., et al. (2021). Oral delivery of proteins and peptides: Challenges, status quo and future perspectives. Acta Pharmaceutica Sinica B, 11(8), 2416-2448. [CrossRef]
  24. Chen, M.C., Sonaje, K., Chen, K.J., et al. (2011). A review of the prospects for polymeric nanoparticle platforms in oral insulin delivery. Biomaterials, 32(36), 9826-9838. [CrossRef]
  25. Easa, N., Alany, R.G., Carew, M., et al. (2019). A review of non-invasive insulin delivery systems for diabetes therapy in clinical trials over the past decade. Drug Discovery Today, 24(2), 440-451. [CrossRef]
  26. Pandey, M., Choudhury, H., Yi, C.X., et al. (2018). Recent updates on novel approaches in insulin drug delivery: A review of challenges and pharmaceutical implications. Current Drug Targets, 19(15), 1782-1800. [CrossRef]
  27. Chen, S., Matsumoto, H., Moro-Oka, Y., et al. (2019). Smart microneedle fabricated with silk fibroin combined semi-interpenetrating network hydrogel for glucose-responsive insulin delivery. ACS Biomaterials Science and Engineering, 5(11), 5781-5789. [CrossRef]
  28. Ratner, R.E. (2018). Hypoglycemia: New definitions and regulatory implications. Diabetes Technology and Therapeutics, 20(S2), S250-S253. [CrossRef]
  29. Demir, G., Er, E., Atik Altınok, Y., et al. (2022). Local complications of insulin administration sites and effect on diabetes management. Journal of Clinical Nursing, 31(17-18), 2530-2538. [CrossRef]
  30. Yu, J., Zhang, Y., Bomba, H., et al. (2016). Stimuli-responsive delivery of therapeutics for diabetes treatment. Bioengineering and Translational Medicine, 1(3), 323-337. [CrossRef]
  31. Peppas, N.A., Bures, P., Leobandung, W., et al. (2000). Hydrogels in pharmaceutical formulations. European Journal of Pharmaceutics and Biopharmaceutics, 50(1), 27-46. [CrossRef]
  32. Bashir, S., Hina, M., Iqbal, J., et al. (2020). Fundamental concepts of hydrogels: Synthesis, properties, and their applications. Polymers, 12(11), 2702. [CrossRef]
  33. Qiu, Y., Park, K. (2001). Environment-sensitive hydrogels for drug delivery. Advanced Drug Delivery Reviews, 53(3), 321-339. [CrossRef]
  34. Ullah, F., Othman, M.B., Javed, F., et al. (2015). Classification, processing and application of hydrogels: A review. Materials Science and Engineering: C, 57, 414-433. [CrossRef]
  35. Sood, N., Bhardwaj, A., Mehta, S., et al. (2016). Stimuli-responsive hydrogels in drug delivery and tissue engineering. Drug Delivery, 23(3), 758-780. [CrossRef]
  36. Liu, B., Chen, K. (2024). Advances in hydrogel-based drug delivery systems. Gels, 10(4), 262. [CrossRef]
  37. Delgado-Pujol, E.J., Martínez, G., Casado-Jurado, D., et al. (2025). Hydrogels and nanogels: Pioneering the future of advanced drug delivery systems. Pharmaceutics, 17(2), 215. [CrossRef]
  38. Hameed, H., Faheem, S., Paiva-Santos, A.C., et al. (2024). A comprehensive review of hydrogel-based drug delivery systems: Classification, properties, recent trends, and applications. AAPS PharmSciTech, 25(4), 64. [CrossRef]
  39. Ahmad, Z., Salman, S., Khan, S.A., et al. (2022). Versatility of hydrogels: From synthetic strategies, classification, and properties to biomedical applications. Gels, 8(3), 167. [CrossRef]
  40. Aswathy, S.H., Narendrakumar, U., Manjubala, I. (2020). Commercial hydrogels for biomedical applications. Heliyon, 6(4), e03719. [CrossRef]
  41. Ho, T.C., Chang, C.C., Chan, H.P., et al. (2022). Hydrogels: Properties and applications in biomedicine. Molecules, 27(9), 2902. [CrossRef]
  42. Thang, N.H., Chien, T.B., Cuong, D.X. (2023). Polymer-based hydrogels applied in drug delivery: An overview. Gels, 9(7), 523. [CrossRef]
  43. Rungrod, A., Kapanya, A., Punyodom, W., et al. (2022). Synthesis and characterization of semi-IPN hydrogels composed of sodium 2-acrylamido-2-methylpropanesulfonate and poly(ε-caprolactone) diol for controlled drug delivery. European Polymer Journal, 164, 110978. [CrossRef]
  44. Zhang, Y., Wu, B.M. (2023). Current advances in stimuli-responsive hydrogels as smart drug delivery carriers. Gels, 9(10), 838. [CrossRef]
  45. Pal, S., Rakshit, T., Saha, S., et al. (2025). Glucose-responsive materials for smart insulin delivery: From protein-based to protein-free design. ACS Materials Au, 5(2), 239-252. [CrossRef]
  46. Yin, R., Wang, K., Du, S., et al. (2014). Design of genipin-crosslinked microgels from concanavalin A and glucosyloxyethyl acrylated chitosan for glucose-responsive insulin delivery. Carbohydrate Polymers, 103, 369-376. [CrossRef]
  47. Traitel, T., Cohen, Y., Kost, J. (2000). Characterization of glucose-sensitive insulin release systems in simulated in vivo conditions. Biomaterials, 21(16), 1679-1687. [CrossRef]
  48. Mandal, D., Mandal, S.K., Ghosh, M., et al. (2015). Phenylboronic acid appended pyrene-based low-molecular-weight injectable hydrogel: Glucose-stimulated insulin release. Chemistry-A European Journal, 21(34), 12042-12052. [CrossRef]
  49. Bauer, J.A., Zámocká, M., Majtán, J., et al. (2022). Glucose oxidase, an enzyme "ferrari": Its structure, function, production and properties in the light of various industrial and biotechnological applications. Biomolecules, 12(3), 472. [CrossRef]
  50. Leskovac, V., Trivić, S., Wohlfahrt, G., et al. (2005). Glucose oxidase from Aspergillus niger: The mechanism of action with molecular oxygen, quinones, and one-electron acceptors. The International Journal of Biochemistry and Cell Biology, 37(4), 731-750. [CrossRef]
  51. Khatami, S.H., Vakili, O., Ahmadi, N., et al. (2022). Glucose oxidase: Applications, sources, and recombinant production. Biotechnology and Applied Biochemistry, 69(3), 939-950. [CrossRef]
  52. Bankar, S.B., Bule, M.V., Singhal, R.S., et al. (2009). Glucose oxidase-An overview. Biotechnology Advances, 27(4), 489-501. [CrossRef]
  53. Rizwan, M., Yahya, R., Hassan, A., et al. (2017). pH sensitive hydrogels in drug delivery: Brief history, properties, swelling, and release mechanism, material selection and applications. Polymers, 9(4), 137. [CrossRef]
  54. Jung, D.Y., Magda, J.J., Han, I.S. (2000). Catalase effects on glucose-sensitive hydrogels. Macromolecules, 33(9), 3332-3336. [CrossRef]
  55. Kim, M.Y., Kim, J. (2017). Chitosan microgels embedded with catalase nanozyme-loaded mesocellular silica foam for glucose-responsive drug delivery. ACS Biomaterials Science and Engineering, 3(4), 572-578. [CrossRef]
  56. Li, X., Fu, M., Wu, J., et al. (2017). pH-sensitive peptide hydrogel for glucose-responsive insulin delivery. Acta Biomaterialia, 51, 294-303. [CrossRef]
  57. Gu, Z., Dang, T.T., Ma, M., et al. (2013). Glucose-responsive microgels integrated with enzyme nanocapsules for closed-loop insulin delivery. ACS Nano, 7(8), 6758-6766. [CrossRef]
  58. Volpatti, L.R., Facklam, A.L., Cortinas, A.B., et al. (2021). Microgel encapsulated nanoparticles for glucose-responsive insulin delivery. Biomaterials, 267, 120458. [CrossRef]
  59. Zhao, J., Xu, G., Yao, X., et al. (2022). Microneedle-based insulin transdermal delivery system: Current status and translation challenges. Drug Delivery and Translational Research, 12(10), 2403-2427. [CrossRef]
  60. Wang, J., Ye, Y., Yu, J., et al. (2018). Core-shell microneedle gel for self-regulated insulin delivery. ACS Nano, 12(3), 2466-2473. [CrossRef]
  61. Ballerstadt, R., Evans, C., McNichols, R., et al. (2006). Concanavalin A for in vivo glucose sensing: A biotoxicity review. Biosensors and Bioelectronics, 22(2), 275-284. [CrossRef]
  62. Lin, K., Yi, J., Mao, X., et al. (2019). Glucose-sensitive hydrogels from covalently modified carboxylated pullulan and concanavalin A for smart controlled release of insulin. Reactive Functional Polymers, 139, 112-119. [CrossRef]
  63. Wu, Q., Wang, L., Yu, H., et al. (2011). Organization of glucose-responsive systems and their properties. Chemical Reviews, 111(12), 7855-7875. [CrossRef]
  64. Yin, R., Tong, Z., Yang, D., et al. (2011). Glucose and pH dual-responsive concanavalin A based microhydrogels for insulin delivery. International Journal of Biological Macromolecules, 49(5), 1137-1142. [CrossRef]
  65. Kim, J.J., Park, K. (2001). Glucose-binding property of pegylated concanavalin A. Pharmaceutical Research, 18(6), 794-799. [CrossRef]
  66. Tanna, S., Taylor, M.J, Sahota, T.S., et al. (2006). Glucose-responsive UV polymerised dextran-concanavalin A acrylic derivatised mixtures for closed-loop insulin delivery. Biomaterials, 27(8), 1586–1597. [CrossRef]
  67. Taylor, M.J., Tanna, S., Sahota, T. (2010). In vivo study of a polymeric glucose-sensitive insulin delivery system using a rat model. Journal of Pharmaceutical Sciences, 99(10), 4215-4227. [CrossRef]
  68. Taylor, M.J., Gregory, R., Tomlins, P., et al. (2016). Closed-loop glycaemic control using an implantable artificial pancreas in diabetic domestic pig (Sus scrofa domesticus). International Journal of Pharmaceutics, 500(1-2), 371-378. [CrossRef]
  69. Wang, C., Lin, B., Zhu, H., et al. (2019). Recent advances in phenylboronic acid-based gels with potential for self-regulated drug delivery. Molecules, 24(6), 1089. [CrossRef]
  70. Huang, Q., Wang, L., Yu, H., et al. (2019). Advances in phenylboronic acid-based closed-loop smart drug delivery system for diabetic therapy. Journal of Controlled Release, 305, 50-64. [CrossRef]
  71. Zhao, L., Huang, Q., Liu, Y., et al. (2017). Boronic acid as glucose-sensitive agent regulates drug delivery for diabetes treatment. Materials, 10(2), 170. [CrossRef]
  72. Lin, Y.R., Hung, C.C., Chiu, H.Y., et al. (2018). Noninvasive glucose monitoring with a contact lens and smartphone. Sensors, 18(10), 3208. [CrossRef]
  73. Matsumoto, A., Chen, S. (2021). A boronate gel-based synthetic platform for closed-loop insulin delivery systems. Polymer Journal, 53, 1305-1314. [CrossRef]
  74. Dong, Y., Wang, W., Veiseh, O., et al. (2016). Injectable and glucose-responsive hydrogels based on boronic acid-glucose complexation. Langmuir, 32(34), 8743-8747. [CrossRef]
  75. Wu, Z., Zhang, X., Guo, H., et al. (2012). An injectable and glucose-sensitive nanogel for controlled insulin release. Journal of Materials Chemistry, 22, 22788-22796. [CrossRef]
  76. Lee, D., Choe, K., Jeong, Y., et al. (2015). Establishment of a controlled insulin delivery system using a glucose-responsive double-layered nanogel. RSC Advances, 5, 14482-14491. [CrossRef]
  77. Zhou, X., Lin, A., Yuan, X., et al. (2016). Glucose-sensitive and blood-compatible nanogels for insulin controlled release. Journal of Applied Polymer Science, 133(24), 1-8. [CrossRef]
  78. Zhao, F., Wu, D., Yao, D., et al. (2017). An injectable particle-hydrogel hybrid system for glucose-regulatory insulin delivery. Acta Biomaterialia, 64, 334-345. [CrossRef]
  79. Chen, X., Yu, H., Wang, L., et al. (2021). Cross-linking-density-changeable microneedle patch prepared from a glucose-responsive hydrogel for insulin delivery. ACS Biomaterials Science and Engineering, 7(10), 4870-4882. [CrossRef]
  80. Lu, Y., Yu, H., Wang, L., et al. (2023). Preparation of phenylboronic acid‐based glucose-responsive hydrogels and microneedles for regulated delivery of insulin. European Polymer Journal, 192, 112061. [CrossRef]
  81. Liu, J., Yi, X., Zhang, J., et al. (2024). Recent advances in the drugs and glucose-responsive drug delivery systems for the treatment of diabetes: A systematic review. Pharmaceutics, 16(10), 1343. [CrossRef]
  82. Wu, W., Zhou, S. (2013). Responsive materials for self-regulated insulin delivery. Macromolecular Bioscience, 13(11), 1464-1477. [CrossRef]
  83. Siegel, R.A. (2014). Stimuli sensitive polymers and self regulated drug delivery systems: A very partial review. Journal of Controlled Release, 190, 337-351. [CrossRef]