Dergiler / Ankara Üniversitesi Eczacılık Fakültesi Dergisi / 2026 / Cilt: 50 Sayı: 3

SAĞLIK FAYDALARI İLE UMUT VAAT EDEN BİLEŞİKLER: FİTOMELATONİN VE MELATONİN

PROMISING COMPOUNDS WITH HEALTH BENEFITS: PHYTOMELATONIN AND MELATONIN

Sultan Pekacar(GAZİ ÜNİVERSİTESİ, ECZACILIK FAKÜLTESİ, ECZACILIK MESLEK BİLİMLERİ BÖLÜMÜ, FARMAKOGNOZİ ANABİLİM DALI)0000-0002-7782-9832
Salih İsmail Kiraz(GAZİ ÜNİVERSİTESİ, ECZACILIK FAKÜLTESİ, ECZACILIK PR.)0009-0004-8314-2502
Ömer Furkan Güverti(GAZİ ÜNİVERSİTESİ, ECZACILIK FAKÜLTESİ, ECZACILIK MESLEK BİLİMLERİ BÖLÜMÜ, FARMAKOGNOZİ ANABİLİM DALI)0009-0006-8258-7264
Didem Deliorman Orhan(GAZİ ÜNİVERSİTESİ, ECZACILIK FAKÜLTESİ, ECZACILIK MESLEK BİLİMLERİ BÖLÜMÜ, FARMAKOGNOZİ ANABİLİM DALI)0000-0003-3916-4048
Sayfa
797–818
Yayın Tarihi
2026-09-19
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⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

Fitomelatonin, fotosentez, hücresel redoks dengesi ve sekonder metabolitlerin düzenlenmesinde görev almakta ve insan sağlığı üzerinde sirkadiyen ritmin düzenlenmesi, oksidatif stresin azaltılması, immün sistemi destekleme ve kanser hücrelerinde apoptozu indükleme gibi çok yönlü etkiler göstermektedir.

📌 3 Maddede Bu Makale

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Amaç & Hipotez:Amaç: Melatonin canlılarda doğal olarak bulunan, antioksidan, antikanser ve antienflamatuvar gibi çeşitli aktivitelere sahip olan bir moleküldür.
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Temel Bulgular & Veri:Çalışma kapsamında, melatonin ve fitomelatoninin biyosentez yolları, bitkisel kaynakları ve kimyasal yapısı detaylandırılmış ve genel etkileri incelenerek güncel literatüre dayalı bilgiler sunulmuştur.
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Sonuç & Katkı:Fitomelatonin, fotosentez, hücresel redoks dengesi ve sekonder metabolitlerin düzenlenmesinde görev almakta ve insan sağlığı üzerinde sirkadiyen ritmin düzenlenmesi, oksidatif stresin azaltılması, immün sistemi destekleme ve kanser hücrelerinde apoptozu indükleme gibi çok yönlü etkiler göstermektedir.
🔬Tür:Laboratuvar & Saha Deneyi
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Antikanser · antioksidan · fitomelatonin

Özet

Amaç: Melatonin canlılarda doğal olarak bulunan, antioksidan, antikanser ve antienflamatuvar gibi çeşitli aktivitelere sahip olan bir moleküldür. Melatonin hormonunun bitkisel türevi olan fitomelatoninin de bitkilerde doğal olarak bulunan ve bitkilerde büyüme, stres toleransı ve çevresel adaptasyonda rol oynayan bir bileşiktir. Melatonin ve fitomelatonin canlılarda doğal olarak bulunduğu gibi esansiyel bir aminoasit olan triptofan aminoasidinden de sentezlenebilmektedir. Çalışma kapsamında, melatonin ve fitomelatoninin biyosentez yolları, bitkisel kaynakları ve kimyasal yapısı detaylandırılmış ve genel etkileri incelenerek güncel literatüre dayalı bilgiler sunulmuştur. Sonuç ve Tartışma: Melatonin, epifiz bezinden salgılanan, sirkadiyen ritmin düzenlenmesi, biyolojik saat uyumu, antikanser ve antienflamatuvar etkilerle homeostazın korunması gibi işlevlerde rol oynayan önemli bir hormondur. Fitomelatonin, fotosentez, hücresel redoks dengesi ve sekonder metabolitlerin düzenlenmesinde görev almakta ve insan sağlığı üzerinde sirkadiyen ritmin düzenlenmesi, oksidatif stresin azaltılması, immün sistemi destekleme ve kanser hücrelerinde apoptozu indükleme gibi çok yönlü etkiler göstermektedir. Bu moleküllerin yapısal ve fonksiyonel benzerlikleri ve etkileri her geçen gün daha fazla ilgi odağı haline gelmelerini sağlamakla beraber yapılacak in vitro ve in vivo çalışmalarla sağlık üzerinde umut vaat eden potansiyellerini ortaya çıkaracaktır.

Abstract

Objective: Melatonin is a molecule naturally found in living organisms and has antioxidant, anticancer, and anti-inflammatory activities. Phytomelatonin, the plant-based derivative of the hormone melatonin, is a naturally occurring compound in plants that plays a role in growth, stress tolerance, and environmental adaptation. Melatonin and phytomelatonin are naturally found in living organisms and can also be synthesized from the essential amino acid tryptophan. Within the scope of the study, the biosynthesis pathways, plant sources, and chemical structures of melatonin and phytomelatonin were detailed, and their general effects were examined, providing information based on current literature. Result and Discussion: Melatonin with its anticancer and anti-inflammatory effects. Phytomelatonin plays a crucial role in photosynthesis, cellular redox balance, and the regulation of secondary metabolites, exhibiting versatile effects on human health. These effects include regulating circadian rhythms, reducing oxidative stress, supporting the is an important hormone secreted by the pineal gland that plays a role in functions such as the regulation of circadian rhythm, synchronization of the biological clock, and the maintenance of homeostasis immune system, and inducing apoptosis in cancer cells. The structural and functional similarities and effects of these molecules are making them increasingly the focus of interest, and in vitro and in vivo studies will reveal their promising potential for health.

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Bu Makaleye Atıf Yap

Pekacar, S., Kiraz, S. İ., Güverti, Ö. F., Orhan, D. D. (2026). SAĞLIK FAYDALARI İLE UMUT VAAT EDEN BİLEŞİKLER: FİTOMELATONİN VE MELATONİN. Ankara Üniversitesi Eczacılık Fakültesi Dergisi, Cilt: 50 Sayı: 3, 797–818. https://doi.org/10.33483/jfpau.1729179

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