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Dergiler / Celal Bayar Üniversitesi Fen Bilimleri Dergisi / 2026 / Cilt: 22 Sayı: 3

Incidence and Dose–Volume Predictors of Radiation-Induced Hypothyroidism in Patients with Locally Advanced Breast Cancer Treated with VMAT

Volkan Demircan(BAHCESEHIR UNIVERSITY)0000-0001-9632-180X
Talar Özler(İstanbul Amerikan Hastanesi Radyasyon Onkolojisi Bölümü)0000-0001-8547-7040
Emre Uysal(SAĞLIK BİLİMLERİ ÜNİVERSİTESİ, İSTANBUL OKMEYDANI SAĞLIK UYGULAMA VE ARAŞTIRMA MERKEZİ)0000-0002-4737-4304
Yaren Ergin(Medicalpark Göztepe Hastanesi Radyasyon Onkolojisi Bölümü)0000-0003-4701-2546
Beyza Kant(Medicalpark Göztepe Hastanesi Radyasyon Onkolojisi Bölümü)0009-0006-8252-0297
Melisa Demirhan(Medicalpark Göztepe Hastanesi Radyasyon Onkolojisi Bölümü)0009-0003-7840-4670
Cengiz Gemici(Bahçeşehir Üniversitesi Tıp Fakültesi Radyasyon Onkolojisi AD)0000-0001-7577-9731
Sayfa
602–615
Yayın Tarihi
2026-09-30
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⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

These findings suggest that patient-related susceptibility may play a greater role than dosimetric factors when contemporary thyroid-sparing VMAT planning is routinely applied, highlighting the importance of baseline thyroid assessment and long-term endocrine surveillance.

📌 3 Maddede Bu Makale

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Amaç & Hipotez:Radiation-induced hypothyroidism (RIHT) is an increasingly recognized late toxicity following regional nodal irradiation for breast cancer; however, thyroid dose constraints remain poorly defined, particularly in the era of modern radiotherapy.
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Temel Bulgular & Veri:This retrospective study investigated the incidence and predictors of RIHT in 95 patients with locally advanced breast cancer treated with volumetric modulated arc therapy (VMAT) including supraclavicular irradiation.
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Sonuç & Katkı:These findings suggest that patient-related susceptibility may play a greater role than dosimetric factors when contemporary thyroid-sparing VMAT planning is routinely applied, highlighting the importance of baseline thyroid assessment and long-term endocrine surveillance.
🔬Tür:Araştırma Makalesi
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Meme kanseri · Radyoterapi · Hipotiroidizm

Abstract

Radiation-induced hypothyroidism (RIHT) is an increasingly recognized late toxicity following regional nodal irradiation for breast cancer; however, thyroid dose constraints remain poorly defined, particularly in the era of modern radiotherapy. This retrospective study investigated the incidence and predictors of RIHT in 95 patients with locally advanced breast cancer treated with volumetric modulated arc therapy (VMAT) including supraclavicular irradiation. Clinical characteristics, thyroid function tests, and thyroid dose-volume parameters (V5–V50, Dmean, and Dmax) were analyzed. During a median follow-up of 30.9 months, RIHT developed in 21 patients (22.1%), and the cumulative incidence increased progressively to 24.0% at 36 months. Baseline thyroid-stimulating hormone level was the only significant predictor of RIHT, whereas no thyroid dose-volume parameter was associated with hypothyroidism. These findings suggest that patient-related susceptibility may play a greater role than dosimetric factors when contemporary thyroid-sparing VMAT planning is routinely applied, highlighting the importance of baseline thyroid assessment and long-term endocrine surveillance.

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Bu Makaleye Atıf Yap

Demircan, V., Özler, T., Uysal, E., Ergin, Y., Kant, B., Demirhan, M., Gemici, C. (2026). Incidence and Dose–Volume Predictors of Radiation-Induced Hypothyroidism in Patients with Locally Advanced Breast Cancer Treated with VMAT. Celal Bayar Üniversitesi Fen Bilimleri Dergisi, Cilt: 22 Sayı: 3, 602–615. https://doi.org/10.18466/cbayarfbe.1983233

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Kaynakça (22)

  1. . Kim J, Harper A, McCormack V, Sung H, Houssami N, Morgan E, Mutebi M, Garvey G, Soerjomataram I, Fidler-Benaoudia MM. Global patterns and trends in breast cancer incidence and mortality across 185 countries. Nat Med. 2025 Apr;31(4):1154-1162.
  2. . Sopik V, Lubiński J, Gronwald J, Huzarski T, Cybulski C, Tryggvadóttir L, Zendehdel K, Nahvijou A, Virani S, Chitapanarux I, Sripan P, Vatanasapt P, Pongnikorn D, Sriplung H, Ginsburg O, Sun P, Akbari M, Narod S. An international cohort study of breast cancer survival in young women. BJC Rep. 2026 Feb 20;4(1):6.
  3. . Foroudi F, Tyldesley S, Walker H, Mackillop WJ. An evidence-based estimate of appropriate radiotherapy utilization rate for breast cancer. Int J Radiat Oncol Biol Phys. 2002 Aug 1;53(5):1240-53.
  4. . Bentzen SM, Constine LS, Deasy JO, Eisbruch A, Jackson A, Marks LB, Ten Haken RK, Yorke ED. Quantitative Analyses of Normal Tissue Effects in the Clinic (QUANTEC): an introduction to the scientific issues. Int J Radiat Oncol Biol Phys. 2010 Mar 1;76(3 Suppl):S3-9.
  5. . Srikantia N, Rishi KS, Janaki MG, Bilimagga RS, Ponni A, Rajeev AG, Kaushik K, Dharmalingam M. How common is hypothyroidism after external radiotherapy to neck in head and neck cancer patients? Indian J Med Paediatr Oncol. 2011 Jul;32(3):143-8.
  6. . Boomsma MJ, Bijl HP, Christianen ME, Beetz I, Chouvalova O, Steenbakkers RJ, van der Laan BF, Wolffenbuttel BH, Oosting SF, Schilstra C, Langendijk JA. A prospective cohort study on radiation-induced hypothyroidism: development of an NTCP model. Int J Radiat Oncol Biol Phys. 2012 Nov 1;84(3):e351-6.
  7. . Rønjom MF, Brink C, Bentzen SM, Hegedüs L, Overgaard J, Johansen J. Hypothyroidism after primary radiotherapy for head and neck squamous cell carcinoma: normal tissue complication probability modeling with latent time correction. Radiother Oncol. 2013 Nov;109(2):317-22.
  8. . Cella L, Liuzzi R, Conson M, D'Avino V, Salvatore M, Pacelli R. Development of multivariate NTCP models for radiation-induced hypothyroidism: a comparative analysis. Radiat Oncol. 2012 Dec 27;7:224.
  9. . Kim MY, Yu T, Wu HG. Dose-volumetric parameters for predicting hypothyroidism after radiotherapy for head and neck cancer. Jpn J Clin Oncol. 2014 Apr;44(4):331-7.
  10. . National Guideline Centre (UK). Management of hypothyroidism: Thyroid disease: assessment and management: Evidence review E. London: National Institute for Health and Care Excellence (NICE); 2019 Nov. (NICE Guideline, No. 145.)
  11. . Wouters HJCM, Wolffenbuttel BHR, Muller Kobold AC, Links TP, Huls G, van der Klauw MM. Hypothyroidism, comorbidity and health-related quality of life: a population-based study. Endocr Connect. 2023 Nov 8;12(12):e230266.
  12. . Teoh M, Clark CH, Wood K, Whitaker S, Nisbet A. Volumetric modulated arc therapy: a review of current literature and clinical use in practice. Br J Radiol. 2011 Nov;84(1007):967-96.
  13. . Kanyilmaz G, Aktan M, Koc M, Demir H, Demir LS. Radiation-induced hypothyroidism in patients with breast cancer: a retrospective analysis of 243 cases. Med Dosim. 2017 Autumn;42(3):190-196.
  14. . Kikawa Y, Kosaka Y, Hashimoto K, Hohokabe E, Takebe S, Narukami R, Hattori T, Ueki K, Ogura K, Imagumbai T, Kato H, Kokubo M. Prevalence of hypothyroidism among patients with breast cancer treated with radiation to the supraclavicular field: a single-centre survey. ESMO Open. 2017 Apr 27;2(1):e000161.
  15. . Solmunde E, Falstie-Jensen AM, Lorenzen EL, Ewertz M, Reinertsen KV, Dekkers OM, Cronin-Fenton DP. Breast cancer, breast cancer-directed radiation therapy and risk of hypothyroidism: A systematic review and meta-analysis. Breast. 2023 Apr;68:216-224.
  16. . Nowicka, Z.; Tomasik, B.; Papis-Ubych, A.; Bibik, R.; Graczyk, Ł.; Latusek, T.; Rutkowski, T.; Wyka, K.; Fijuth, J.; Schoenfeld, J.D.; Fendler W. Radiation-Induced Hypothyroidism in Patients with Oropharyngeal Cancer Treated with IMRT: Independent and External Validation of Five Normal Tissue Complication Probability Models. Cancers 2020, 12, 2716.
  17. . Boomsma MJ, Bijl HP, Langendijk JA. Radiation-induced hypothyroidism in head and neck cancer patients: a systematic review. Radiother Oncol. 2011 Apr;99(1):1-5.
  18. . Zhao XR, Fang H, Jing H, Tang Y, Song YW, Liu YP, Jin J, Chen B, Qi SN, Tang Y, Lu NN, Li N, Li YX, Wang SL. Radiation-Induced Hypothyroidism in Patients With Breast Cancer After Hypofractionated Radiation Therapy: A Prospective Cohort Study. Int J Radiat Oncol Biol Phys. 2023 Jan 1;115(1):83-92.
  19. . Pollack RM, Kagan M, Lotem M, Dresner-Pollak R. Baseline Tsh Level Is Associated With Risk Of Anti-Pd-1-Induced Thyroid Dysfunction. Endocr Pract. 2019 Aug;25(8):824-829.
  20. . Aminorroaya A, Meamar R, Amini M, Feizi A, Nasri M, Tabatabaei A, Faghihimani E. The TSH levels and risk of hypothyroidism: Results from a population based prospective cohort study in an Iranian adult's population. Eur J Intern Med. 2017 Jun;41:55-61.
  21. . Fröhlich E, Wahl R. Thyroid Autoimmunity: Role of Anti-thyroid Antibodies in Thyroid and Extra-Thyroidal Diseases. Front Immunol. 2017 May 9;8:521.
  22. . Attard CC, Sze WCC, Vella S. Predictors of autoimmune thyroid disease. Proc (Bayl Univ Med Cent). 2022 Jun 15;35(5):608-614.