KaydedilenlerDerginizi ekleyin

Dergiler / European Journal of Biology / 2021 / Volume: 80 Issue: 2

Protective Effects of Petroselinum crispum (Parsley) Extract Against Methotrexate-Induced Hepatotoxicity

Büşra Ertaş(Marmara University, School of Pharmacy, Department of Pharmacology, Istanbul, Turkey)0000-0001-8374-1098
Feyza Berin Turan(Marmara University, School of Pharmacy, Department of Pharmacology, Istanbul, Turkey)0000-0002-0436-7876
Dilek Özbeyli(Marmara University, Vocational School of Health Services, Medical Pathology Techniques, Istanbul, Turkey)0000-0002-0250-9535
Refiye Yanardağ(Istanbul University, Faculty of Engineering, Department of Biochemistry, Istanbul, Turkey)0000-0003-4185-4363
Özlem Saçan(Istanbul University, Faculty of Engineering, Department of Biochemistry, Istanbul, Turkey)0000-0001-6503-4613
Göksel Şener(Fenerbahce University, Vocational School of Health Services, Istanbul, Turkey)0000-0001-7444-6193
Sayfa
—
Yayın Tarihi
2021-12-17
🏛️Bu makalenin bibliyografik verileri ve tam metin bağlantısı DergiPark üzerinden sağlanmıştır.
DergiPark Kaydı ↗
✨

Yapay Zeka Hızlı Bakış & Çıkarımlar

AI Insight
⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

Conclusion: It appears that the administration of PCr to MTX treated rats prevented the accumulation of lipid peroxides, inflamatory reactions and depletion of antioxidant glutathione, and thus protected liver tissues against oxidative stress.

📌 3 Maddede Bu Makale

🎯
Amaç & Hipotez:Objective: By inhibiting the synthesis of thymidine and purine, and thereby DNA synthesis, Methotrexate (MTX), suppresses the proliferation of cancer cells.
📊
Temel Bulgular & Veri:Materials and Methods: Sprague Dawley rats (female/male; 200-250 g) were used.
💡
Sonuç & Katkı:Conclusion: It appears that the administration of PCr to MTX treated rats prevented the accumulation of lipid peroxides, inflamatory reactions and depletion of antioxidant glutathione, and thus protected liver tissues against oxidative stress.
🔬Tür:Research Article
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Methotrexate · Petroselinum crispum · hepatotoxicity

Abstract

Objective: By inhibiting the synthesis of thymidine and purine, and thereby DNA synthesis, Methotrexate (MTX), suppresses the proliferation of cancer cells. It is thought that the side-effect mechanism is related to oxidant molecules derived from MTX metabolism. In this study, we examined whether the Petroselinum crispum extracts (PCr; parsley) of which the antioxidant properties have been previously shown, was protective against MTX induced liver damage. Materials and Methods: Sprague Dawley rats (female/male; 200-250 g) were used. MTX was injected intraperitoneally and PCr extract was given orally. A single dose of 20mg/kg MTX was administered to the groups that were to experience hepatotoxicity. Then, a physiological saline (MTX group) or PCr (2 g/kg, MTX + PCr group) treatment was applied for 5 days. The same treatments were applied to the other groups (control group, PCr group) for 5 days after a single dose saline injection. At the end of the study, the biochemical parameters were examined in the blood and liver tissues taken from animals sacrificed by decapitation. Results: MTX caused a significant increase in malondialdehyde and collagen levels and myeloperoxidase and caspase-3 activities, while glutathione levels were found to have decreased. PCr treatment showed protective efficacy by preventing these increases. Conclusion: It appears that the administration of PCr to MTX treated rats prevented the accumulation of lipid peroxides, inflamatory reactions and depletion of antioxidant glutathione, and thus protected liver tissues against oxidative stress.

🔖

Bu Makaleye Atıf Yap

Ertaş, B., Turan, F. B., Özbeyli, D., Yanardağ, R., Saçan, Ö., Şener, G. (2021). Protective Effects of Petroselinum crispum (Parsley) Extract Against Methotrexate-Induced Hepatotoxicity. European Journal of Biology, Volume: 80 Issue: 2. https://doi.org/10.26650/EurJBiol.2021.1023136

📄 Tam Metin PDF Okuyucu

📄

PDF görüntüleyici hazırlanıyor...

Kaynakça (37)

  1. Wang W, Zhou H, Liu L. Side effects of methotrexate therapy for rheumatoid arthritis: A systematic review. Eur J Med Chem 2018; 158: 502-16. google scholar
  2. Rizzi R, Curci P, Delia M, Rinaldi E, Chiefa A, Specchia G, et al. Spon-taneous remission of “methotrexate-associated lymphoprolifera-tive disorders” after discontinuation of immunosuppressive treat-ment for autoimmune disease. Review of the literature. Med Oncol 2009; 26 (1): 1-9. google scholar
  3. Sayılmaz A, Karabulut YY, Özgörgülü A. The histopathological eval-uation of healing effects of vitamin C administered before metho-trexate therapy on testicular injury induced by methotrexate. Turk J Urol 2016; 42(4): 235-9. google scholar
  4. El-Sheikh AA, Morsy MA, Al-Taher AY. Multi-drug resistance protein (Mrp) 3 may be involved in resveratrol protection against metho-trexate-induced testicular damage. Life Sci 2014; 119(1-2): 40-6. google scholar
  5. Taguchi T. [Side effects of cancer chemotherapy and steps to deal with them]. Gan To Kagaku Ryoho. 1995; 22(14): 2017-28. google scholar
  6. Goto E, Hosomi M, Nishihara M, Goto M, Yoshida M, Kii T, et al. [Comparison of chemotherapy side effects between elderly and young subjects]. Gan To Kagaku Ryoho 2012; 39(13): 2527-31. google scholar
  7. Jahovic N, Cevik H, Sehirli AO, Yeğen BC, Sener G. Melatonin pre-vents methotrexate-induced hepatorenal oxidative injury in rats. J Pineal Res 2003; 34(4): 282-7. google scholar
  8. Athreya K, Xavier MF. Antioxidants in the Treatment of Cancer. Nutr Cancer 2017; 69(8): 1099-104. google scholar
  9. Ozsoy-Sacan O, Yanardag R, Orak H, Ozgey Y, Yarat A, Tunali T. Ef-fects of parsley (Petroselinum crispum) extract versus glibornuride on the liver of streptozotocin-induced diabetic rats. J Ethnophar-macol 2006; 104(1-2): 175-81. google scholar
  10. Tunali T, Yarat A, Yanardağ R, Ozçelik F, Ozsoy O, Ergenekon G, et al. Effect of parsley (Petroselinum crispum) on the skin of STZ induced diabetic rats. Phytother Res 1999; 13(2): 138- 41. google scholar
  11. Malayeri A, Badparva R, Mombeini MA, Khorsandi L, Goudarzi M. Naringenin: a potential natural remedy against methotrexate-in-duced hepatotoxicity in rats. Drug Chem Toxicol 2020: 1-8. google scholar
  12. Yanardağ R, Bolkent S, Tabakoğlu-Oğuz A, Ozsoy-Saçan O. Effects of Petroselinum crispum extract on pancreatic B cells and blood glucose of streptozotocin-induced diabetic rats. Biol Pharm Bull 2003; 26(8): 1206-10. google scholar
  13. Sener G, Paskaloglu K, Toklu H, Kapucu C, Ayanoglu-Dulger G, Kac-maz A, et al. Melatonin ameliorates chronic renal failure-induced oxidative organ damage in rats. J Pineal Res 2004; 36(4): 232-41. google scholar
  14. Sener G, Sehirli AO, Ayanoglu-Dülger G. Melatonin protects against mercury(II)-induced oxidative tissue damage in rats. Phar-macol Toxicol 2003; 93(6): 290-6. google scholar
  15. Hillegass LM, Griswold DE, Brickson B, Albrightson-Winslow C. As-sessment of myeloperoxidase activity in whole rat kidney. J Phar-macol Methods 1990; 24(4): 285-95. google scholar
  16. Lopez-De Leon A, Rojkind M. A simple micromethod for collagen and total protein determination in formalin-fixed paraffin-embed-ded sections. J Histochem Cytochem 1985; 33(8): 737-43. google scholar
  17. Burmester GR, Pope JE. Novel treatment strategies in rheumatoid arthritis. Lancet 2017; 389(10086): 2338-48. google scholar
  18. Seideman P, Beck O, Eksborg S, Wennberg M. The pharmacokinet-ics of methotrexate and its 7-hydroxy metabolite in patients with rheumatoid arthritis. Br J Clin Pharmacol 1993; 35(4): 409-12. google scholar
  19. Conway R, Carey JJ. Risk of liver disease in methotrexate treated patients. World J Hepatol 2017; 9(26): 1092-100. google scholar
  20. Kim J, Kim KY, Jang HS, Yoshida T, Tsuchiya K, Nitta K, et al. Role of cytosolic NADP+-dependent isocitrate dehydrogenase in isch-emia-reperfusion injury in mouse kidney. Am J Physiol Renal Physi-ol 2009; 296(3): F622-33. google scholar
  21. Espinosa-Diez C, Miguel V, Mennerich D, Kietzmann T, San-chez-Perez P, Cadenas S, et al. Antioxidant responses and cellular adjustments to oxidative stress. Redox Biol 2015; 6: 183-97. google scholar
  22. Eki Nci-Akdemi R FN, Yildirim S, Kandemi R FM, Gülçi N İ, Küçükler S, Sağlam YS, et al. The effects of casticin and myricetin on liver damage induced by methotrexate in rats. Iran J Basic Med Sci 2018; 21(12): 1281-8. google scholar
  23. Sherif IO, Al-Shaalan NH. Hepatoprotective effect of Ginkgo biloba extract against methotrexate-induced hepatotoxicity via target-ing STAT3/miRNA-21 axis. Drug Chem Toxicol 2020: 1-9. google scholar
  24. Famurewa AC, Folawiyo AM, Epete MA, Igwe EC, Okike PI, Maduag-wuna EK. Abrogation of Hepatic Damage Induced by Anticancer Drug Methotrexate by Zobo (Hibiscus sabdariffa extract) Supple-mentation via Targeting Oxidative Hepatotoxicity in Rats. J Diet Suppl 2019; 16(3): 318-30. google scholar
  25. Liberal Â, Fernandes Â, Polyzos N, Petropoulos SA, Dias MI, Pinela J, et al. Bioactive Properties and Phenolic Compound Profiles of Turnip-Rooted, Plain-Leafed and Curly-Leafed Parsley Cultivars. Molecules 2020; 25(23): 5606. google scholar
  26. Bolkent S, Yanardag R, Ozsoy-Sacan O, Karabulut-Bulan O. Effects of parsley (Petroselinum crispum) on the liver of diabetic rats: a morphological and biochemical study. Phytother Res 2004; 18(12): 996-9. google scholar
  27. Ozel AB, Cilingir-Kaya OT, Sener G, Ozbeyli D, Sen A, Sacan O, et al. Investigation of possible neuroprotective effects of some plant extracts on brain in bile duct ligated rats. J Food Biochem 2021: e13835. google scholar
  28. Sener G, Kapucu C, Paskaloglu K, Ayanoglu-Dülger G, Arbak S, Er-soy Y, et al. Melatonin reverses urinary system and aorta damage in the rat due to chronic nicotine administration. J Pharm Pharmacol 2004; 56(3): 359-66. google scholar
  29. Sener G, Ekşioğlu-Demiralp E, Cetiner M, Ercan F, Yeğen BC. Be-ta-glucan ameliorates methotrexate-induced oxidative organ in-jury via its antioxidant and immunomodulatory effects. Eur J Phar-macol 2006; 542(1-3): 170-8. google scholar
  30. Nauseef WM, Metcalf JA, Root RK. Role of myeloperoxidase in the respiratory burst of human neutrophils. Blood 1983; 61(3): 483-92. google scholar
  31. Mortaz E, Alipoor SD, Adcock IM, Mumby S, Koenderman L. Update on Neutrophil Function in Severe Inflammation. Front Immunol 2018; 9: 2171. google scholar
  32. Abdellatief SA, Galal AA, Farouk SM, Abdel-Daim MM. Ameliorative effect of parsley oil on cisplatin-induced hepato-cardiotoxicity: A biochemical, histopathological, and immunohistochemical study. Biomed Pharmacother 2017; 86: 482-91. google scholar
  33. Al Kury LT, Dayyan F, Ali Shah F, Malik Z, Khalil AAK, Alattar A, et al. Ginkgo biloba Extract Protects against Methotrexate-Induced Hepatotoxicity: A Computational and Pharmacological Approach. Molecules 2020; 25 (11). google scholar
  34. Ali N, Rashid S, Nafees S, Hasan SK, Sultana S. Beneficial effects of Chrysin against Methotrexate-induced hepatotoxicity via atten-uation of oxidative stress and apoptosis. Mol Cell Biochem 2014; 385(1-2): 215-23. google scholar
  35. Kelleni MT, Ibrahim SA, Abdelrahman AM. Effect of captopril and telmisartan on methotrexate-induced hepatotoxicity in rats: im-pact of oxidative stress, inflammation and apoptosis. Toxicol Mech Methods 2016; 26(5): 371-7. google scholar
  36. De S, Kundu S, Chatterjee U, Chattopadhyay S, Chatterjee M. Al-lylpyrocatechol attenuates methotrexate-induced hepatotoxicity in a collagen-induced model of arthritis. Free Radic Res 2018; 52(6): 698-711. google scholar
  37. Tawfik MK. Combination of coenzyme Q10 with methotrexate sup-presses Freund’s complete adjuvant-induced synovial inflamma-tion with reduced hepatotoxicity in rats: Effect on oxidative stress and inflammation. Int Immunopharmacol 2015; 24(1): 80-7. google scholar