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Dergiler / Harran Üniversitesi Tıp Fakültesi Dergisi / 2026 / Cilt: 23 Sayı: 2

Fibromiyalji Hastalarında Serum Plazma Total Oksidan/Antioksidan, Tiyol-Disülfit ve Asprosin Düzeylerinin İncelenmesi

Investigation of Serum Plasma Total Oxidant/Antioxidant, Thiol-Disulfide, and Asprosin Levels in Fibromyalgia Patients

Ali Güneri(GAZİANTEP ŞEHİR HASTANESİ)0000-0002-2632-8309
Serap Satış(Vm medikalpark ankara)0000-0002-5496-197X
Müjgan Ercan(YÜKSEK İHTİSAS ÜNİVERSİTESİ, TIP FAKÜLTESİ)0000-0002-9291-4197
Sayfa
274–282
Yayın Tarihi
2026-06-26
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Amaç: Fibromiyalji; etiyolojisi belirsiz olan, kas iskelet sistemi bulguları ve birçok somatik semptomun eşlik ettiği kronik bir sendrom olarak tanımlanmaktadır.

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Amaç & Hipotez:Amaç: Fibromiyalji; etiyolojisi belirsiz olan, kas iskelet sistemi bulguları ve birçok somatik semptomun eşlik ettiği kronik bir sendrom olarak tanımlanmaktadır.
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Temel Bulgular & Veri:Materyal ve metod: Yeni tanılı 20-50 yaş aralığındaki Fibromiyalji sendromlu kadın hastalar ile aynı yaş grubunda sağlıklı gönüllü kadınlar çalışmaya dahil edildi.
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Sonuç & Katkı:Bulgularımız ayrıca oksidatif-antioksidatif denge ve tiyol-disülfit homeostazında kısmi bir değişiklik olabileceğini düşündürmektedir.
🔬Tür:Araştırma Makalesi
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Fibromiyalji · oksidatif stres · adipokinler

Özet

Amaç: Fibromiyalji; etiyolojisi belirsiz olan, kas iskelet sistemi bulguları ve birçok somatik semptomun eşlik ettiği kronik bir sendrom olarak tanımlanmaktadır. Bu çalışmada, total antioksidan seviye, total oksidan seviye, tiyol-disülfit homeostazı ve asprosin düzeylerini inceleyip, Fibromiyalji sendromu etyopatogenezine katkı sağlamayı amaçladık. Materyal ve metod: Yeni tanılı 20-50 yaş aralığındaki Fibromiyalji sendromlu kadın hastalar ile aynı yaş grubunda sağlıklı gönüllü kadınlar çalışmaya dahil edildi. Her iki grubun plazma natif tiyol, total tiyol, disülfit, natif tiyol/total tiyol, disülfit/natif tiyol, disülfit/total tiyol, total antioksidan seviye, total oksidan seviye ve oksidatif stres indeksi değerleri ile asprosin değerlerine bakıldı. Bulgular: Total antioksidan seviye, total oksidan seviye ve total tiyol seviyeleri hasta grubunda daha düşük; disülfit/natif tiyol oranı hasta grubunda daha yüksek olup; aradaki farklar istatistiksel olarak anlamlı idi (p=0,024, p<0,001, p=0,050, p=0,050). Fibromiyalji sendromu grubunda yaş ile total antioksidan seviye, total tiyol değerleri arasında pozitif korelasyon (r=0,361 p=0,020, r=0,314 p=0,045) ve natif tiyol ile negatif korelasyon (r=0,354 p=0,023) vardı. Fibromiyalji sendromu grubunda vücut kitle indeksi ile asprosin ve total oksidatif seviye arasında pozitif korelasyon (r=0,743 p<0,001, r=0,356 p=0,022); kontrol grubunda vücut kitle indeksi ile total antioksidan seviye arasında negatif korelasyon vardı (r=0,429 p=0,005). Yaygın ağrı indeksi sadece asprosin ile pozitif koreleydi (r=0,309 p=0,049). Sonuç: Fibromiyalji sendromunda, serum asprosin düzeyleri gruplar arasında anlamlı farklılık göstermemekle birlikte, vücut kitle indeksi ve yaygın ağrı indeksi ile olan pozitif korelasyonları olası bir ilişkiye işaret edebilir. Bulgularımız ayrıca oksidatif-antioksidatif denge ve tiyol-disülfit homeostazında kısmi bir değişiklik olabileceğini düşündürmektedir.

Abstract

Background: Fibromyalgia is defined as a chronic syndrome of uncertain etiology, accompanied by musculoskeletal findings and numerous somatic symptoms. In this study, we aimed to contribute to understanding the etiopathogenesis of fibromyalgia syndrome by examining total antioxidant status, total oxidant status, thiol-disulfide homeostasis, and asprosin levels. Materials and Methods: Newly diagnosed female patients with fibromyalgia syndrome between the ages of 20-50 and healthy female volunteers in the same age range were included in the study. Plasma native thiol, total thiol, disulfide, native thiol/total thiol, disulfide/native thiol, disulfide/total thiol, total antioxidant level, total oxidant level, oxidative stress index, and asprosin values of both groups were measured. Results: Total antioxidant level, total oxidant level and total thiol levels were lower in the patient group; the disulfide/native thiol ratio was higher in the patient group; the differences were statistically significant (p=0.024, p<0.001, p=0.050, p=0.050). In the fibromyalgia syndrome group, there was a positive correlation between age and total antioxidant level and total thiol values (r=0.361, p=0.020; r=0.314, p=0.045, respectively) and a negative correlation with native thiol (r=0.354, p=0.023). There was a positive correlation between body mass index (BMI) and asprosin and total oxidative level in the fibromyalgia syndrome group (r=0.743, p<0.001; r=0.356, p=0.022, respectively); there was a negative correlation between BMI and total antioxidant level in the control group (r=0.429, p=0.005). The Widespread Pain Index was positively correlated only with asprosin (r=0.309, p=0.049). Conclusions: Although no significant difference was found between the groups in terms of serum asprosin levels in fibromyalgia syndrome, the positive correlations of asprosin with BMI and the Widespread Pain Index may suggest an association with metabolic status and pain extent. In addition, our findings indicate partial alterations in oxidative-antioxidative balance and thiol-disulfide homeostasis in fibromyalgia syndrome rather than a uniform disturbance across all parameters.

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Bu Makaleye Atıf Yap

Güneri, A., Satış, S., Ercan, M. (2026). Fibromiyalji Hastalarında Serum Plazma Total Oksidan/Antioksidan, Tiyol-Disülfit ve Asprosin Düzeylerinin İncelenmesi. Harran Üniversitesi Tıp Fakültesi Dergisi, Cilt: 23 Sayı: 2, 274–282. https://doi.org/10.35440/hutfd.1800388

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