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Dergiler / ODÜ Tıp Dergisi / 2026 / Cilt: 2 Sayı: 1

Leptin Hormonunun Özellikleri

Ali Aslan
Sibel Sarı
Sevil Arabacı
Sayfa
36–40
Yayın Tarihi
2015-01-01
DOI
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Yapay Zeka Hızlı Bakış & Çıkarımlar

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⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

Bu derlemede leptinin özellikleri ve sistemler üzerine olan etkileri özetlendi

📌 3 Maddede Bu Makale

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Amaç & Hipotez:Friedman ve arkadaşları tarafından 1994 yılında ilk kez tanımlanan ve primer olarak adipositlerden salınan leptin, enerji dengesi ve vücut ağırlığının korunmasında etkili peptid yapıda bir hormondur.
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Temel Bulgular & Veri:Friedman ve arkadaşları tarafından 1994 yılında ilk kez tanımlanan ve primer olarak adipositlerden salınan leptin, enerji dengesi ve vücut ağırlığının korunmasında etkili peptid yapıda bir hormondur.
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Sonuç & Katkı:Bu derlemede leptinin özellikleri ve sistemler üzerine olan etkileri özetlendi
🔬Tür:Literatür & Derleme Çalışması
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Leptin · nörolojik · psikiyatrik

Özet

Friedman ve arkadaşları tarafından 1994 yılında ilk kez tanımlanan ve primer olarak adipositlerden salınan leptin, enerji dengesi ve vücut ağırlığının korunmasında etkili peptid yapıda bir hormondur. Bu derlemede leptinin özellikleri ve sistemler üzerine olan etkileri özetlendi

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Bu Makaleye Atıf Yap

Aslan, A., Sarı, S., Arabacı, S. (2015). Leptin Hormonunun Özellikleri. ODÜ Tıp Dergisi, Cilt: 2 Sayı: 1, 36–40. https://ajindex.com/articles/1071804

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Kaynakça (72)

  1. Zhang Y, Proenca R, Maffei M, Barone M, Leopold L, Friedman JM. Positional cloning of the mouse obese gene and its human homologue. Nature. 1994 1;372(6505):425-32.
  2. Isse N, Ogawa Y, Tamura N, et al. Structural organization and chromosomalassignment of the human obese gene. J Biol Chem 1995; 270:27728–27733.
  3. Gong DW, Bi S, Pratley RE, Weintraub BD. Genomic structure and promoter analysis of the human obese gene. J Biol Chem1996; 271: 3971–3974.
  4. Priego T, Sánchez J, Palou A, Picó C. Effect of high-fat diet feeding on leptin receptor expression in white adipose tissue in rats: depot- and sex-related differential response. Genes Nutr. 2009;4(2):151-6.
  5. Señarís R, Garcia-Caballero T, Casabiell X, et al., Synthesis of leptin in human placenta, Endocrinology. 1997;138(10):4501- 4.
  6. Glasow A, Kiess W, Anderegg U, Berthold A, Bottner A, Kratzsch J., Expression of leptin (Ob) and leptin receptor (Ob-R) in human fibroblasts: regulation of leptin secretion by insülin, J Clin Endocrinol Metab. 2001;86(9):4472-9.
  7. Reseland JE, Syversen U, Bakke I, et al. Leptin is expressed in and secreted from primary cultures of human osteoblasts and promotes bone mineralization. J Bone Miner Res. 2001;16(8):1426-33.
  8. Wang J, Liu R, Hawkins M, Barzilai N, Rossetti L., A nutrient-sensing pathway regulates leptin gene expression in muscle and fat, Nature. 1998 18;393(6686):684-8.
  9. Bado A, Levasseur S, Attoub S, et al. The stomach is a source of leptin. Nature. 1998 Aug 20;394(6695):790-3.
  10. Purdham DM, Zou MX, Rajapurohitam V, Karmazyn M. Rat heart is a site of leptin production and action. Am J Physiol Heart Circ Physiol. 2004;287(6):H2877-84.
  11. Chen H, Zhang JP, Huang H, Wang ZH, Cheng R, Cai WB., Leptin promotes fetal lung maturity and upregulates SP-A expression in pulmonary alveoli type-II epithelial cells involving TTF-1 activation, PLoS One. 2013 22;8(7):e69297.
  12. Tartaglia LA, Dembski M, Weng X, et al.: IdentiŞcation and expression cloning of a leptin receptor, OB-R. Cell 1995, 83:1263-1271.
  13. Guo Z, Jiang H, Xu X, Duan W, Mattson MP.Leptin- mediated cell survival signaling in hippocampalneurons mediated by JAK STAT3 andmitochondrial stabilization. J Biol Chem 2008;283: 1754-1763.
  14. Marwarha G, Ghribi O. Leptin signaling and Alzheimer's disease. Am J Neurodegener Dis. 2012;1(3):245-65.
  15. Schwartz MW, Seeley RJ, Campfield LA, Burn P, Baskin DG. Identification of targets of leptin action in rat hypothalamus. J Clin Invest. 1996;98(5):1101-6.
  16. Couce ME, Burguera B, Parisi JE, Jensen MD, Lloyd RV. Localization of leptin receptor in the human brain. Neuroendocrinology. 1997;66(3):145-50.
  17. Elmquist JK, Bjİrbaek C, Ahima RS, Flier JS, Saper CB. Distributions of leptin receptor mRNA isoforms in the rat brain. J Comp Neurol. 1998;395(4):535-47.
  18. Hâkansson ML, Brown H, Ghilardi N, Skoda RC, Meister B. Leptin receptor immunoreactivity in chemically defined target neurons of the hypothalamus. J Neurosci. 1998;18(1):559-72.
  19. Pathak RR, Grover A, Malaney P, et al. Loss of phosphatase and tensin homolog (PTEN) induces leptin-mediated leptin gene expression: feed-forward loop operating in the lung, J Biol Chem. 2013 11;288(41):29821-35.
  20. Attig L, Brisard D, Larcher T, et al., Postnatal leptin promotes organ maturation and development in IUGR piglets, PLoS One. 2013 31;8(5):e64616.
  21. Chakrabarti J, Chatterjee R, Goswami S, et al., Leptin and the adrenal gland, Eur J Clin Invest. 2000 Dec;30 Suppl 3:39-45. Overt leptin response to controlled ovarian hyperstimulation negatively correlates with pregnancy outcome in in vitro fertilization--embryo transfer cycle. J Hum Reprod Sci. 2012;5(2):194-9.
  22. Pilka L, Rumpík D, Pilka R. Role of leptin in human reproduction 2012;77(6):484-5. bulimia). Ceska Gynekol
  23. Park SH, Ho WK, Jeon JH., AMPK regulates K(ATP) channel trafficking via PTEN inhibition in leptin-treated pancreatic β-cells, Biochem Biophys Res Commun. 2013 1;440(4):539-44.
  24. Włodarski K, Włodarski P. Leptin as a modulator of osteogenesis. Ortop Traumatol Rehabil 2009 Jan-Feb;11(1):1- 6.
  25. Behnes M, Brueckmann M, Lang S, et al. Alterations of leptin in the course of inflammation and severe sepsis. BMC Infect Dis 2012 Sep 14;12:217.
  26. Chehab FF, Lim ME, Ronghua L. Correction of the sterility defect in homozygous obese female mice by treatment with the human recombinant leptin. Nat Genet 1996;12:318–20.
  27. Marroquí L, Vieira E, Gonzalez A, Nadal A, Quesada I., Leptin downregulates expression of the gene encoding glucagon in alphaTC1-9 cells and mouse islets, Diabetologia.
  28. Etemad A, Ramachandran V, Pishva SR, et al., Analysis of Gln223Agr polymorphism of Leptin Receptor Gene in type II diabetic mellitus subjects among Malaysians, Int J Mol Sci. 2013 18;14(9):19230-44.
  29. Wang TN, Chang WT, Chiu YW, et al., Relationships between changes in leptin and insulin resistance levels in obese individuals following weight loss, Kaohsiung J Med Sci. 2013;29(8):436-43.
  30. Liu C, Grossman A, Bain S, et al. 1997 Leptin stimulates cortical bone formation in obese (ob/ob) mice. J Bone Miner Res 12(Suppl1):S115
  31. Steppan CM, Crawford DT, Chidsey-Frink KL, Ke H, Swick AG 2000 Leptin is a potent stimulator of bone growth in ob/ob mice. Regul Pept 92:73-78.
  32. Gordeladze JO, Drevon CA, Syversen U et al., Leptin stimulates Human Osteoblastic Cell Proliferation de novo collagen synthesis and mineralization. J Cell Biochem 2002, 85: 825-836.
  33. Batra A, Okur B, Glauben R, et al., Leptin: a critical regulator of CD4+ T-cell polarization in vitro and in vivo, Endocrinology. 2010;151(1):56-62.
  34. Fernández-Riejos P, Najib S, Santos-Alvarez J, et al., Role of leptin in the activation of immune cells, Mediators Inflamm. 2010;2010:568343.
  35. Tschöp J, Nogueiras R, Haas-Lockie S, et al., CNS leptin action modulates immune response and survival in sepsis, J Neurosci. 2010 28;30(17):6036-47.
  36. Warren MW, Hynan LS, Weiner MF., Lipids and adipokines as risk factors for Alzheimer's disease, J Alzheimers Dis. 2012;29(1):151-7.
  37. Markaki E, Ellul J, Kefalopoulou Z, et al., The role of ghrelin, neuropeptide Y and leptin peptides in weight gain after deep brain stimulation for Parkinson's disease, Stereotact Funct Neurosurg. 2012;90(2):104-12.
  38. Kantorova E, Chomova M, et al., Leptin, adiponectin and ghrelin, new potential mediators of ischemic stroke, Neuro Endocrinol Lett. 2011;32(5):716-21.
  39. Zeki Al Hazzouri A, Haan MN, Whitmer RA, Yaffe K, Neuhaus J. Central obesity, leptin and cognitive decline: the Sacramento Area Latino Study on Aging. Dement Geriatr Cogn Disord. 2012;33(6):400-9.
  40. Beeri MS, Haroutunian V, Schmeidler J, et al., Synaptic
  41. protein deficits are associated with dementia irrespective of extreme old age, Neurobiol Aging. 2012;33(6):1125.e1-8.
  42. Bonda DJ, Stone JG, Torres SL, et al., Dysregulation of leptin
  43. signaling in Alzheimer disease: evidence for neuronal leptin resistance, J Neurochem. 2014;128(1):162-72.
  44. Randhawa BK, Farley BG, Boyd LA., Repetitive transcranial magnetic stimulation improves handwriting in Parkinson's disease, Parkinsons Dis. 2013;2013:751925.
  45. Schapira AH., Recent developments in biomarkers in Parkinson disease, Curr Opin Neurol. 2013;26(4):395-400.
  46. Benskey M, Lee KY, Parikh K, Lookingland KJ, Goudreau JL., Sustained resistance to acute MPTP toxicity by hypothalamic dopamine neurons following chronic neurotoxicant exposure is associated with sustained up- regulation of parkin protein, Neurotoxicology. 2013;37:144- 53.
  47. Lynch JJ 3rd, Shek EW, Castagné V, Mittelstadt SW. The proconvulsant effects of leptin on glutamate receptor- mediated seizures in mice. Brain Res Bull. 2010 29;82(1-2):99- 103.
  48. Aslan A, Yildirim M, Ayyildiz M, Güven A. Agar E Interaction of leptin and nitric oxide pathway on penicillin- induced epileptiform activity in rats. Brain Res 2010 19;1321:117-24.
  49. Aslan A, Yildirim M, Ayyildiz M, Güven A, Agar E. The role of nitric oxide in the inhibitory effect of ghrelin against penicillin-induced epileptiform activity in rat. Neuropeptides. 2009;43(4):295-302.
  50. Jayaram B, Khan RS, Kastin AJ, Hsuchou H, Wu X, Pan W., Protective role of astrocytic leptin signaling against excitotoxicity, J Mol Neurosci. 2013;49(3):523-30.
  51. Zhang F, Wang S, Signore AP, Chen J. Neuroprotective effects of leptin against ischemic injury induced by oxygen- glucose deprivation and transient cerebral ischemia. Stroke. 2007;38(8):2329-36.
  52. Avraham Y, Davidi N, Lassri V, et al. Leptin induces neuroprotection neurogenesis and angiogenesis after stroke. Curr Neurovasc Res. 2011 Nov;8(4):313-22.
  53. Avraham Y, Dayan M, Lassri V, et al. Delayed leptin administration after stroke induces neurogenesis and angiogenesis. J Neurosci Res 2013;91(2):187-95.
  54. Zhang J, Deng Z, Liao J, et al. Leptin attenuates cerebral ischemia injury through the promotion of energy metabolism via the PI3K/Akt pathway. J Cereb Blood Flow Metab. 2013;33(4):567-74.
  55. Edvinsson L, Warfvinge K. CGRP receptor antagonism and migraine therapy. Curr Protein Pept Sci. 2013;14(5):386-92.
  56. Guldiken B, Guldiken S, Demir M, Turgut N, Tugrul A. Low leptin levels in migraine: a case control study. Headache. 2008;48(7):1103-7.
  57. Hirfanoglu T, Serdaroglu A, Gulbahar O, Cansu A. Prophylactic drugs and cytokine and leptin levels in children with migraine. Pediatr Neurol. 2009;41(4):281-7.
  58. Zupancic ML, Mahajan A., Leptin as a neuroactive agent, Psychosom Med. 2011 Jun;73(5):407-14.
  59. Brewerton TD, Lesem MD, Kennedy A, Garvey WT. Reduced plasma leptin concentrations in bulimia nervosa. Psychoneuroendocrinology. 2000;25(7):649-58.
  60. Jimerson DC, Mantzoros C, Wolfe BE, Metzger ED. Decreased serum leptin in bulimia nervosa. J Clin Endocrinol Metab. 2000;85(12):4511-4.
  61. Monteleone P, Martiadis V, Colurico B, Maj M. Leptin secretion is related to chronicity and severity of illness in bulimia nervosa. Psychosom Med 2002; 64: 874– 9.
  62. Takayanagi Y, Cascella NG, Santora D, Gregory PE, Sawa A, Eaton WW. Relationships between serum leptin level and severity of positive symptoms in schizophrenia. Neurosci Res. 2013;77(1-2):97-101.
  63. Zhang ZJ, Yao ZJ, Mou XD, et al. Association of -2548G/A functional polymorphism in the promoter region of leptin gene with antipsychotic agent-induced weight gain. Zhonghua Yi Xue Za Zhi. 2003 25;83(24):2119-23.
  64. Herrán A, García-Unzueta MT, Amado JA, de La Maza MT, Alvarez C, Vázquez-Barquero JL. Effects of long-term treatment with antipsychotics on serum leptin levels. Br J Psychiatry. 2001;179:59-62.
  65. Peña R, Marquina D, Serrano A, et al., Frequency of abnormal correlation between leptin and the body mass index during first and second generation antipsychotic drug treatment, Schizophr Res. 2008;106(2-3):315-9.
  66. Panariello F, Polsinelli G, Borlido C, Monda M, De Luca V., The role of leptin in antipsychotic-induced weight gain: genetic and non-genetic factors, J Obes. 2012;2012:572848.
  67. Atmaca M, Kuloglu M, Tezcan E, Gecici O, Ustundag B., Serum cholesterol and leptin levels in patients with borderline personality disorder, Neuropsychobiology. 2002;45(4):167-71.
  68. Lu X, Kim C, Frazer A, Zhang W. Leptin: a potential novel antidepressant. Proc Natl Acad Sci U S A 2006; 103: 1593– 8.
  69. Garza JC, Guo M, Zhang W, Lu XY. Leptin restores adult hippocampal neurogenesis in a chronic unpredictable stress model of depression and reverses glucocorticoid-induced inhibition of GSK-3β/β-catenin signaling. Mol Psychiatry.
  70. Ge JF, Qi CC, Zhou JN., Imbalance of leptin pathway and hypothalamus synaptic plasticity markers are associated with stress-induceddepression in rats, Behav Brain Res. 2013 15;249:38-43.
  71. Warren MW, Hynan LS, Weiner MF., Lipids and adipokines as risk factors for Alzheimer's disease, J Alzheimers Dis. 2012;29(1):151-7.
  72. Markaki E, Ellul J, Kefalopoulou Z, et al., The role of ghrelin, neuropeptide Y and leptin peptides in weight gain after deep brain stimulation for Parkinson's disease, Stereotact Funct Neurosurg. 2012;90(2):104-12.