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Dergiler / Pamukkale Üniversitesi Mühendislik Bilimleri Dergisi / 2026 / Cilt: 32 Sayı: 5

Hidrojen peroksitin tespiti için kalem grafit elektrotlar üzerine nanoyapılı CeO₂'nin elektrokimyasal biriktirilmesi

Electrochemical deposition of nanostructured CeO₂ on pencil graphite electrodes for hydrogen peroxide detection

Hülya Öztürk Doğan(ATATURK UNIVERSITY)
Neslihan Çelebi(ATATURK UNIVERSITY)
Arzu Kavaz Yüksel(ATATURK UNIVERSITY)
Sayfa
1121–1127
Yayın Tarihi
2026-09-13
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⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

Elektrokimyasal olarak biriktirilen CeO₂'nin tek kullanımlık PGE'lerle entegrasyonu, biyomedikal teşhis ve çevresel analizde potansiyel uygulamalara sahip, hassas, uygun maliyetli ve gerçek zamanlı H₂O₂ algılama için yeni ve etkili bir yaklaşım sunmaktadır.

📌 3 Maddede Bu Makale

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Amaç & Hipotez:Bu araştırmada, düşük maliyetli ve enzimsiz bir algılama platformu geliştirmek için nanoyapılı seryum oksit (CeO₂), kontrollü oksijenasyon koşulları altında kalem grafit elektrotlar (PGE'ler) üzerine elektrokimyasal olarak biriktirildi.
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Temel Bulgular & Veri:Döngüsel voltammetri ve kronoamperometri ile yapılan elektrokimyasal ölçümler, 8.4 nM'lik düşük bir tespit limiti ve 313.26 μA.mM⁻¹'lik yüksek bir hassasiyet elde ederek mükemmel katalitik performans gösterdi.
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Sonuç & Katkı:Elektrokimyasal olarak biriktirilen CeO₂'nin tek kullanımlık PGE'lerle entegrasyonu, biyomedikal teşhis ve çevresel analizde potansiyel uygulamalara sahip, hassas, uygun maliyetli ve gerçek zamanlı H₂O₂ algılama için yeni ve etkili bir yaklaşım sunmaktadır.
🔬Tür:Araştırma Makalesi
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Seryum oksit · elektrokimyasal biriktirme · enzimatik olmayan H2O2 sensörü

Özet

Bu araştırmada, düşük maliyetli ve enzimsiz bir algılama platformu geliştirmek için nanoyapılı seryum oksit (CeO₂), kontrollü oksijenasyon koşulları altında kalem grafit elektrotlar (PGE'ler) üzerine elektrokimyasal olarak biriktirildi. CeO₂ nanoyapıların analitik karakterizasyonu, XRD, Raman spektroskopisi ve EDS kullanılarak gerçekleştirildi. Morfolojik görüntüleme ise FESEM kullanılarak gerçekleştirildi. Modifiye edilmiş PGE'ler, hidrojen peroksitin (H₂O₂) tespiti için elektrokimyasal sensörler olarak incelendi. Döngüsel voltammetri ve kronoamperometri ile yapılan elektrokimyasal ölçümler, 8.4 nM'lik düşük bir tespit limiti ve 313.26 μA.mM⁻¹'lik yüksek bir hassasiyet elde ederek mükemmel katalitik performans gösterdi. Elektrokimyasal olarak biriktirilen CeO₂'nin tek kullanımlık PGE'lerle entegrasyonu, biyomedikal teşhis ve çevresel analizde potansiyel uygulamalara sahip, hassas, uygun maliyetli ve gerçek zamanlı H₂O₂ algılama için yeni ve etkili bir yaklaşım sunmaktadır.

Abstract

In this investigation, nanostructured cerium oxide (CeO₂) was electrochemically deposited onto pencil graphite electrodes (PGEs) under controlled oxygenation conditions to develop a low-cost and enzyme-free sensing platform. The analytical characterization of CeO₂ nanostructures was conducted using XRD, Raman spectroscopy, and EDS. Morphological imaging was performed using a FESEM. The modified PGEs were investigated as an electrochemical sensors for hydrogen peroxide (H₂O₂) detection. Electrochemical measurements via cyclic voltammetry and chronoamperometry revealed excellent catalytic performance, achieving a low detection limit of 8.4 nM and a high sensitivity of 313.26 μA.mM⁻¹. The integration of electrochemically deposited CeO₂ with disposable PGEs presents a novel and effective approach for sensitive, cost-efficient, and real-time H₂O₂ sensing, with potential applications in biomedical diagnostics and environmental analysis.

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Bu Makaleye Atıf Yap

Doğan, H. Ö., Çelebi, N., Yüksel, A. K. (2026). Hidrojen peroksitin tespiti için kalem grafit elektrotlar üzerine nanoyapılı CeO₂'nin elektrokimyasal biriktirilmesi. Pamukkale Üniversitesi Mühendislik Bilimleri Dergisi, Cilt: 32 Sayı: 5, 1121–1127. https://doi.org/10.65206/pajes.94820

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Kaynakça (39)

  1. Andrés CMC, Pérez de la Lastra JM, Juan CA, Plou FJ, Pérez-Lebeña E. “Chemistry of hydrogen peroxide formation and elimination in mammalian cells, and its role in various pathologies”. Stresses, 2(3), 3, 2022.
  2. Maynard S, Schurman SH, Harboe C, de Souza-Pinto NC, Bohr VA. “Base excision repair of oxidative DNA damage and association with cancer and aging”. Carcinogenesis, 30(1), 12-10, 2009.
  3. Lyublinskaya O, Antunes F. “Measuring intracellular concentration of hydrogen peroxide with the use of genetically encoded H2O2 biosensor HyPer”. Redox Biology, 24, 101200, 2019.
  4. Liu J, Li M, Liu W, Hao Z, Zhang F, Pang H, Zhang R, Zhang L. “Advances in non-enzymatic electrochemical materials for H2O2 sensing”. Journal of Electroanalytical Chemistry, 954, 118060, 2024.
  5. Lin KC, Tsai TH, Chen SM. “Performing enzyme-free H2O2 biosensor and simultaneous determination for AA, DA, and UA by MWCNT-PEDOT film”. Biosensors and Bioelectronics, 26(2), 608-614, 2010.
  6. Wang T, Yang L, Zhang B, Liu J. “Extracellular biosynthesis and transformation of selenium nanoparticles and application in H2O2 biosensor”. Colloids and Surfaces B: Biointerfaces, 80(1), 94-102, 2010.
  7. Thatikayala D, Ponnamma D, Sadasivuni KK, Cabibihan J, Al-Ali AK, Malik RA, Min B. “Progress of advanced nanomaterials in the non-enzymatic electrochemical sensing of glucose and H2O2”. Biosensors, 10(11), 11, 2020.
  8. Doğan HÖ, Çepni E, Urhan BK, Eryiğit M. “Non-enzymatic amperometric detection of H2O2 on one-step electrochemical fabricated Cu2O/electrochemically reduced graphene oxide nanocomposite”. ChemistrySelect, 4(28), 8317-8321, 2019.
  9. Xiong X, You C, Cao X, Pang L, Kong R, Sun X. “Ni2P nanosheets array as a novel electrochemical catalyst electrode for non-enzymatic H2O2 sensing”. Electrochimica Acta, 253, 517-521, 2017.
  10. Doğan HÖ, Akbulak T, Nadaroğlu H, Hacımüftüoğlu A. “Electrochemical determination of nitrate on Ag nanoparticles-decorated poly (direct blue 15) electrodes”. Electroanalysis, 35(9), e202200442, 2023.
  11. Govindaraj M, Srivastava A, Muthukumaran MK, Tsai PC, Lin Y, Raja BK, Rajendran J, Ponnusamy VK, Selvi JA. “Current advancements and prospects of enzymatic and non-enzymatic electrochemical glucose sensors”. International Journal of Biological Macromolecules, 253(2), 126680, 2023.
  12. Wu Q, Zhou X, Li P, You S, Ye J, Bao P, Chen X, Tong H, Wang S. “Non-enzymatic electrochemical sensor based on Pt/MoSe2 nanomesh for the detection of hydrogen peroxide”. Materials Chemistry and Physics, 310, 128496, 2023.
  13. Giaretta JE, Duan H, Oveissi F, Farajikhah S, Dehghani F, Naficy S. “Flexible enzymatic sensors for detection of hydrogen peroxide”. IEEE Sensors, 1, 1-4. 2021.
  14. Khadhraoui H, Othmani A, Kouki A, Zouaoui M. “A highly sensitive and selective non-enzymatic hydrogen peroxide sensor based on nanostructured Co3O4 thin films using the sol-gel method”. Electroanalysis, 33(1), 152-159, 2021.
  15. Onat EK, Kamaç MB, Yılmaz M. “A disposable non-enzymatic dual sensor for simultaneous amperometric determination of NADH and H2O2”. Journal of Applied Electrochem, 53, 2213-2227, 2023.
  16. Li Y, Zhang JJ, Xuan J, Jiang LP, Zhu JJ. “Fabrication of a novel nonenzymatic hydrogen peroxide sensor based on Se/Pt nanocomposites”. Electrochemistry Communications, 12(6), 777-780, 2010.
  17. Yıldız HB, Carbas BB, Sonmezoglu S, Karaman M, Toppare L. “A photoelectrochemical device for water splitting using oligoaniline-crosslinked [Ru(bpy)2(bpyCONHArNH2)]+2 dye/IrO2 nanoparticle array on TiO2 photonic crystal modified electrode”. International Journal of Hydrogen Energy, 41(33), 14615-14629, 2016.
  18. Cevik E, Carbas BB, Senel M, Yıldız HB. “Construction of conducting polymer/cytochrome C/thylakoid membrane based photo-bioelectrochemical fuel cells generating high photocurrent via photosynthesis”. Biosensors and Bioelectronics, 113, 25-31, 2018.
  19. Yıldız HB, Cevik E, Carbas BB. “Nanotechnology for biological photovoltaics; industrial applications of nanomaterials”. Industrial Applications of Nanomaterials Micro and Nano Technologies, 3, 65-89, 2019.
  20. Matussin SN, Harunsani MH, Khan MM. “CeO2 and CeO2-based nanomaterials for photocatalytic, antioxidant and antimicrobial activities”. Journal of Rare Earths, 41(2), 167-181, 2023.
  21. Xu Y, Zhou Y, Li Y, Liu Y, Ding Z. “Advances in cerium dioxide nanomaterials: Synthesis strategies, property modulation, and multifunctional applications”. Journal of Environmental Chemical Engineering, 12(5), 113719, 2024.
  22. Sun C, Li H, Chen L. “Nanostructured ceria-based materials: synthesis, properties, and applications”. Energy Environmental Science, 5(9), 8475-8505, 2012.
  23. Kaushal I, Kumar V, Saharan P, Mittal A, Bhagat R, Kumar S, Sharma AK. “Electrochemical energy storage and hydrogen peroxide sensing using hybrid framework of CeO2-MnO2 on carbon nano fiber composite”. Journal of Alloys and Compounds, 934, 167740, 2023.
  24. Montini T, Melchionna M, Monai M, Fornasiero P. “Fundamentals and catalytic applications of CeO2-based materials”. Chemical Reviews, 116(10), 5987-6041, 2016.
  25. Muruganandam G, Nesakumar N, Kulandaisamy AJ, Rayappan JBB, Gunasekaran BM. “Fabrication of electrochemical sensor for the detection of Mg(II) ions using CeO2 microcuboids as an efficient electrocatalyst”. Chemosensors, 11(8), 442, 2023.
  26. Mukherjee A, Ashrafi AM, Bytesnikova Z, Svec P, Richtera L, Adam V. “An investigation on the multiple roles of CeO2 nanoparticle in electrochemical sensing: Biomimetic activity and electron acceptor”. Journal of Electroanalytical Chemistry, 935, 117301, 2023.
  27. Çelebi N, Temur E, Doğan H.Ö, Yüksel AK. “The electrochemical fabrication of Cu@CeO2-rGO electrode for high-performance electrochemical nitrite sensor”. Diamond and Related Materials, 143, 110907, 2024.
  28. Sonawane LD, Mandawade AS, Bhoye LN, Ahemad HI, Tayade SS, Aher YB, Gite AB, Nikam LK, Shinde SD, Jain GH, Patil GE, Shinde MS. “Sol-gel and hydrothermal synthesis of CeO2 NPs: Their physiochemical properties and applications for gas sensor with photocatalytic activities”. Inorganic Chemistry Communications, 164, 112313, 2024.
  29. Moreno OP, Pérez RG, Merino RP, Portillo MC, Tellez GH, Rosas ER, Tototzintle MZ. “CeO2 nanoparticles growth by chemical bath and its thermal annealing treatment in air atmosphere”. Optik, 148, 142-150, 2017.
  30. Pethaperumal S, Mohanraj GT, Vediappan K, Kavibharathy K. “Nano-micro 2D/3D SnO2 semiconductor ultrahigh sensitive sensors for electrochemical sensing of hydrogen peroxide”. Sensors and Actuators A: Physical, 370, 115212, 2024.
  31. Kong DR, Gao Y, Xin Y, Li B, Zhang X, Deng Z, Huo L, Gao S. “Controlled preparation of spinel CoCr2O4 nanocrystals with variable proportions of mixed redox couplings for enhanced sensing to hydrogen peroxide”. Ceramics International, 49(11), 19206-19215, 2023.
  32. Sun Y, Li S, Dai Y, Zhang H, Luo C. “An electrochemical biosensor for the detection of BRCA1 based on MOF-derived CeO2@CuS nanosheets with high electrocatalytic H2O2 reduction performance”. Analytica Chimica Acta, 1345, 343765, 2025.
  33. Kosto Y, Zanut A, Franchi S, Yakovlev Y, Khalakhan I, Matolín V, Prince KC, Valenti G, Paolucci F, Tsud N. “Electrochemical activity of the polycrystalline cerium oxide films for hydrogen peroxide detection”. Applied Surface Science, 488, 351-359, 2019.
  34. Bracamonte MV, Melchionna M, Giuliani A, Nasi L, Tavagnacco C, Prato M, Fornasiero P. “H2O2 sensing enhancement by mutual integration of single walled carbon nanohorns with metal oxide catalysts: The CeO2 case”. Sensors and Actuators B: Chemical, 239, 923-932, 2017.
  35. Rajendran S, Manoj D, Suresh R, Vasseghian Y, Ghfar AA, Sharma G, Soto-Moscoso M. “Electrochemical detection of hydrogen peroxide using micro and nanoporous CeO2 catalysts”. Environmental Research, 214(3), 113961, 2022.
  36. Güler M, Türkoğlu V, Kıvrak A, Karahan F. “A novel nonenzymatic hydrogen peroxide amperometric sensor based on Pd@CeO2-NH2 nanocomposites modified glassy carbon electrode”. Materials Science and Engineering: C, 90, 454-460, 2018.
  37. Ghaedamini H, Kim DS. “A non-enzymatic hydrogen peroxide biosensor based on cerium metal-organic frameworks, hemin, and graphene oxide composite”. Bioelectrochemistry, 161, 108823, 2025.
  38. Zhou H, Zheng H, Shi W, Ma X. “Template-synthesizing hollow cubic CeO2/Co3O4 heterostructure as electrocatalysts for sensing hydrogen peroxide”. Scripta Materialia, 255, 116397, 2025.
  39. Manibalan G, Murugadoss G, Krishnamoorthy D, Dharuman V, Peera SG. “Sensitive and selective electrochemical detection of hydrogen peroxide using a silver-incorporated CeO2/Ag2O nanocomposite”. Biosensors, 15(9), 617, 2025.