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Dergiler / Journal of Cellular Neuroscience and Oxidative Stress / 2025 / Volume: 17 Issue: 2

The Oxidative DNA Damage Marker 8-OHdG Indicates No Clear Association to Newly Detected Breast Cancer in Women

Shireen Al-tameemi
Rana Hameed
Mohammed Alqanbar
Sayfa
1261–1269
Yayın Tarihi
2025-10-07
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⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

Our findings suggest that 8-OHdG may not serve as a general screening biomarker for breast cancer, as its levels were comparable across all clinical and pathological parameters examined.

📌 3 Maddede Bu Makale

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Amaç & Hipotez:The role of 8-hydroxydeoxyguanosine (8-OHdG) as a biomarker in breast cancer remains controversial with conflicting results across studies.
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Temel Bulgular & Veri:This case-control study aimed at comparing serum 8-OHdG levels between breast cancer patients and healthy controls, and examine associations with clinical characteristics.
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Sonuç & Katkı:Our findings suggest that 8-OHdG may not serve as a general screening biomarker for breast cancer, as its levels were comparable across all clinical and pathological parameters examined.
🔬Tür:Uygulamalı Anket & Alan Araştırması
📍Kapsam:2024 Verileri
⚙️Değişkenler:8-hydroxy-2 · breast neoplasms · oxidative stress

Abstract

The role of 8-hydroxydeoxyguanosine (8-OHdG) as a biomarker in breast cancer remains controversial with conflicting results across studies. This case-control study aimed at comparing serum 8-OHdG levels between breast cancer patients and healthy controls, and examine associations with clinical characteristics. Thus, 71 Iraqi women (47 newly diagnosed, treatment-naïve breast cancer patients and 24 controls) were used from November 2024 to June 2025. Demographic data and lifestyle factors were collected through structured questionnaires. No significant difference was found in median 8-OHdG levels between breast cancer patients and controls. No correlations were observed between 8-OHdG and age, BMI, tumor grade, or hormone receptor status. Our findings suggest that 8-OHdG may not serve as a general screening biomarker for breast cancer, as its levels were comparable across all clinical and pathological parameters examined.

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Bu Makaleye Atıf Yap

Al-tameemi, S., Hameed, R., Alqanbar, M. (2025). The Oxidative DNA Damage Marker 8-OHdG Indicates No Clear Association to Newly Detected Breast Cancer in Women. Journal of Cellular Neuroscience and Oxidative Stress, Volume: 17 Issue: 2, 1261–1269. https://doi.org/10.37212/jcnos.1746366

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Kaynakça (12)

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