KaydedilenlerDerginizi ekleyin

Dergiler / Natural Science and Discovery / 2015 / Cilt: 1 Sayı: 2

Potent antioxidant and genotoxic effects of ammonium tetraborate in vitro

Fatih Celikezen
Hasan Turkez
Elanur Aydin
Mehmet Izgi
Burcin Celikezen
Sayfa
45–9
Yayın Tarihi
2015-06-30
DOI
—
🏛️Bu makalenin bibliyografik verileri ve tam metin bağlantısı DergiPark üzerinden sağlanmıştır.
DergiPark Kaydı ↗
✨

Yapay Zeka Hızlı Bakış & Çıkarımlar

AI Insight
⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

Moreover, ammonium tetraborate showed antioxidant activities at low concentrations and the total oxidative stress levels were not changed at all the concentrations of ammonium tetraborate.Conclusion: our data clearly indicated that ammonium tetraborate is not mutagenic and it has remerkable antioxidant potential in vitro.

📌 3 Maddede Bu Makale

🎯
Amaç & Hipotez:Aim: Boron shows antioxidant properties with an unknown mechanism.
📊
Temel Bulgular & Veri:It was aimed to evaluate the antioxidant potentials and genotoxic risk of ammonium tetraborate on human whole blood cultures for the first time in the extent of this study (n=4).Material and Methods: Ammonium tetraborate was administrated at concentrations between 1,25- 1280 µg/ml to cultured blood samples.
💡
Sonuç & Katkı:Moreover, ammonium tetraborate showed antioxidant activities at low concentrations and the total oxidative stress levels were not changed at all the concentrations of ammonium tetraborate.Conclusion: our data clearly indicated that ammonium tetraborate is not mutagenic and it has remerkable antioxidant potential in vitro.
🔬Tür:Araştırma Makalesi
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Ammonium tetraborate · Chromosomal aberrations · micronucleus test

Abstract

Aim: Boron shows antioxidant properties with an unknown mechanism. It was aimed to evaluate the antioxidant potentials and genotoxic risk of ammonium tetraborate on human whole blood cultures for the first time in the extent of this study (n=4).Material and Methods: Ammonium tetraborate was administrated at concentrations between 1,25- 1280 µg/ml to cultured blood samples. The micronuclei and chromosomal aberration tests were performed to determine genotoxic effect. In addition, total antioxidant capacity and total oxidative stress levels were measured as biochemical parameters.Results: Our results clearly provded that the all tested concentrations of ammonium tetraborate were not-mutagenic. Moreover, ammonium tetraborate showed antioxidant activities at low concentrations and the total oxidative stress levels were not changed at all the concentrations of ammonium tetraborate.Conclusion: our data clearly indicated that ammonium tetraborate is not mutagenic and it has remerkable antioxidant potential in vitro.

🔖

Bu Makaleye Atıf Yap

Celikezen, F., Turkez, H., Aydin, E., Izgi, M., Celikezen, B. (2015). Potent antioxidant and genotoxic effects of ammonium tetraborate in vitro. Natural Science and Discovery, Cilt: 1 Sayı: 2, 45–9. https://ajindex.com/articles/1003453

📄 Tam Metin PDF Okuyucu

📄

PDF görüntüleyici hazırlanıyor...

Kaynakça (17)

  1. Howe PD. A review of boron effects in the environment. Bio Trace Elem Res. 661(998), 153–166.
  2. Rainey, C.J, Nyquist, L.A, Christensen, R.E, Strong, P.L, Culver, B.D, Coughlin, J.R. Daily boron intake from the American diet. J The Am Diet Ass. 99 (1999) 335–40.
  3. Hunt, C.D. Regulation of enzymatic activity: One possible role of dietary boron in higher animals and humans. Bio Trace Elem Res. 66 (1998) 205–225.
  4. Sutherland, B., Leslie, R., Woodhouse, P.S., Janet, C.K. Boron balance in humans. J Trace Elemt Exp Med. 12 (1999) 271–284.
  5. Barranco WT, Eckhert CD. Boric acid inhibits human prostate cancer cell proliferation. Cancer Lett. 216 (2004) 21–29.
  6. Cui, Y., Winton, M.I., Zhang, Z.F., Rainey, C., Marshall, J. De., Kernion, J.B., Eckhert, CD. Dietary boron intake and prostate cancer risk. Onc Rep 11(2006), 887–892.
  7. Yazbeck, C., Kloppmann, W., Cottier, R., Sahuquillo, J., Debotte, G., Huel, G. Health impact evaluation of boron in drinking water: a geographical risk assessment in Northern France. Env Geochem Healt. 27 (2005). 419–427.
  8. Newnham, R.E. The role of boron in human nutrition. J App Nut 46 (1994) 81–85.
  9. Chapin, R.E., Warren, W.K., Mary, A.K., Harrıett, M., Beth, G., Robert, N.W., Ralph W, Michael, R.E. The effects of dietary boron on bone strength in rats. Fundem and App Tox. 35 (1997) 205–215.
  10. Devirian, T.A., Volpe, S.L. The physiological effect of dietary boron. Crit Rev of Food Sci and Nut. 43 (2003) 219–231.
  11. Türkez, H., Geyikoğlu, F., Tatar, A. Borax counteracts genotoxicity of aluminum in rat liver. Tox and Ind Health 29 (2013) 775-779.
  12. Gallardo-Williams, M.T., Maronpot, R.R., Wine, R.N., Brunssen, S.H., Chapin, R.E. Inhibition of the enzymatic activity of prostate-specific antigen by boric acid and 3-Nitrophenyl boronic acid. Prostate 54 (2003) 44–49
  13. Korkmaz, M., Uzgören, E., Bakırdere, S., Aydın, F., Ataman, O.Y. Effects of dietary boron on cervical cytopathology and on micronucleus frequency in exfoliated buccal cells. Envir Tox 22 (2007) 17–25.
  14. Çelikezen, F.Ç., Turkez, H., Togar, B., Izgi, M.S. DNA damaging and biochemical effects of potassium tetraborate. EXCLI J 13 (2014) 446-450.
  15. Nielsen, F. The emergence of boron as nutritionally important throughout the lifecycle. Nutrition 16 (2000) 512–514.
  16. Nielsen, F. Biochemical and physiological consequences of boron deprivation in humans. Envi Health Persp 102 (1994) 59–63.
  17. Armstrong, T., Spears, J. Effect of boron supplementation of pig diets on the production of tumor necrosis factor-a and interferon-