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Dergiler / Journal of Clinical and Experimental Investigations / 2017 / Cilt: 8 Sayı: 3

The Physiological and Genotoxic Effects of Water and Ethanol Extracts of Goji Berry (Lycium barbarum L.) on Model Organisms

Hülya ÖZPINAR
Necati ÖZPINAR
Savas KARAKUS
Sayfa
76–84
Yayın Tarihi
2017-09-30
DOI
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⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

It must be emphasised that doserelated side-effects may develop with the use of plants for medicinal purposes.

📌 3 Maddede Bu Makale

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Amaç & Hipotez:Objectives: Herbal treatments in particular have a place which cannot be ignored in current alternative medicine.
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Temel Bulgular & Veri:To investigate the effects of Goji berry, on fertility when used by individuals in their 20s and on physical growth when used by those of a younger age.
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Sonuç & Katkı:It must be emphasised that doserelated side-effects may develop with the use of plants for medicinal purposes.
🔬Tür:Modelleme & Sayısal Simülasyon
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Goji Berry · Caenorhabditis elegans · Fertility

Abstract

Objectives: Herbal treatments in particular have a place which cannot be ignored in current alternative medicine. One of these plants, which has become very well-known recently and which is widely consumed in Turkey is the Goji berry (Lycium barbarum L.). To investigate the effects of Goji berry, on fertility when used by individuals in their 20s and on physical growth when used by those of a younger age. It was also aimed to test the genotoxic effects of the Goji berry on Allium cepa L. meristem stem cells. Materials and Methods: Goji berry water and ethanol extracts were tested on a model organism of Caenorhabditis elegans (C. elegans) in respect of fertility and physical growth. Allium cepa L. meristem stem cells exposed to Goji berry extract were examined for genotoxic effects. Results: A significant dose-related reduction was determined in fertility, physical growth and mitotic index in ethanol extract. In the water extract, a reduction in fertility was determined at high doses and an increase with the lowest dose used in the study. No significant effect was found on physical growth of water extract at any dose. Conclusion: The results of this study showed negative effects on cell division, fertility and physical growth of Goji berry, which has been used since ancient times in Chinese medicine and for which several benefits have been claimed in literature. It must be emphasised that doserelated side-effects may develop with the use of plants for medicinal purposes.

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Bu Makaleye Atıf Yap

ÖZPINAR, H., ÖZPINAR, N., KARAKUS, S. (2017). The Physiological and Genotoxic Effects of Water and Ethanol Extracts of Goji Berry (Lycium barbarum L.) on Model Organisms. Journal of Clinical and Experimental Investigations, Cilt: 8 Sayı: 3, 76–84. https://ajindex.com/articles/1001153

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Kaynakça (14)

  1. Amagase H, Farnsworth NR. A review of botanical characteristics, phytochemistry, clinical relevance in efficacy and safety of Lycium barbarum fruit (Goji). Food Res Int. 2011;44:1702-7
  2. Bryan JK, Casta D, Giese N, Nummy K, Rapp C, Seamon E. Goji (Lyciumspp) in natural standard monograph. 2008. Natural Standard Inc
  3. Dag S, Ozpinar H, Sari M, Ozpinar N. Antimicrobial effect of cola on several microorganisms. Cumhuriyet Sci J. 2015;36 52-9
  4. Potterat O. Goji (Lycium barbarum and L. chinense): phytochemistry, pharmacology and safety in the perspective of traditional uses and recent popularity. Planta Med. 2010;76 7-19
  5. Fabricant DS, Farnsworth NR. The value of plants used in traditional medicine for drug discovery. Environ Health Perspect. 2001;109:69-78
  6. Chan HC, Chang RCC, Ip AKC, et al. Neuroprotective effects of Lycium barbarum Lynn on protecting retinal ganglion cells in an ocular hypertension model of glaucoma. Expe Neurol. 2007;203:269-73
  7. Chalasani SH, Chronis N, Tsunozaki M, Gray JM, Ramot D, Goodman MB, et al. Corrigendum: Dissecting a circuit for olfactory behaviour in Caenorhabditis elegans. Nature. 2016;533:130 8. Ono K, Ono S. Two distinct myosin II populations coordinate ovulatory contraction of the myoepithelial sheath in the Caenorhabditis elegans somatic gonad. Mol Biol Ccell. 2016:27:1131-42
  8. Ozpinar H, Ozpinar N, Kilicgun H, Dag S, Sari M. Physiological and lifespan alterations in Caenorhabditis elegans exposed to Benzoic acid. SSTB. 2011;7:39-47
  9. Olgun A, Aleksenko T, Pereira-Smith OM, Vassilatis DK. Functional analysis of MRG-1: The ortholog of human MRG15 in Caenorhabditis elegans. J Gerontol A Biol Sci Med Sci. 2005;60:543-8
  10. Turkoglu S. Genotoxicity of five food preservatives tested on root tips of Allium cepa L. Mutat Res Genet Toxicol Environ Mutagen. 2007;626:4- 14
  11. Koelle MR, Horvitz HR. EGL-10 regulates G protein signaling in the C. elegans nervous system and shares a conserved domain with many mammalian proteins. Cell. 1996;84:115-25
  12. Li X, Li X, Zhou A. Evaluation of antioxidant activity of the polysaccharides extracted from Lycium barbarum fruits in vitro. Eur Polym J. 2007;43:488-97
  13. Lin CL, Wang CC, Chang SC, Inbaraj BS, Chen BH. Antioxidative activity of polysaccharide fractions isolated from Lycium barbarum Linnaeus. Int j biol Macromol. 2009;45:146-51
  14. Wu SJ, Ng LT, Lin CC. Antioxidant activities of some common ingredients of traditional chinese medicine, Angelica sinensis, Ly