Hepatocellular Carcinoma in a Van Cat

Abstract

In this report, hepatocellular carcinoma in a 5·years-old female Van cat was described. Grossly, grayishwhile nodular masses 01 0,1-6 cm in diameters were found in the liver, spleen, lung. kidneys, abdomen and under the skm. Microscopically, tumor cells were arranged as solid, cord·like and trabecular pattern. Neoplastic cells usually had polygonal and vesicular nuclei and had multiple mitotic figures. Immunohistochemically some tumor markers such as alpha-fetoprotein (AFP), cylokeratin, smooth muscle actin (SMA), and factor VIiI·related antigen (FVIII-Rag) was also studied, and AFP and SMA were found to be positive.