Miscarriage in a patient with Glanzmann Thrombasthenia and low ovarian reserve: a case report

Abstract

Glanzmann thrombasthenia (GT) is an autosomal recessive hemorrhagic disorder mostly complicated by mucocutaneous bleeding. The severity of this bleeding disorder varies from mild bruising to frequent severe bleeding. Prepartum, peripartum and postpartum bleeding risks are increased in these patients. In addition to the hemorrhagic complications which endanger maternal and fetal wellbeing, the risk of miscarriage is increased due to maternal antibodies to the platelets which are also found on conceptus-derived trophoblast (placental) cells. This case report is about a patient with GT, complicated by infertility, low ovarian reserve, HPV positivity and bilateral dermoid cyst, who had a miscarriage in 7+1 week.