Serum Asymmetric Dimethyl Arginine Level is Associated with the Pain Intensity in Primary Dysmenorrhea

Abstract

Background: Aim of this study is the investigation of the association between Serum Asymmetric Dimethyl Arginine (ADMA) levels and menstrual pain intensity as assessed by Visual Analogue Scale in primary dysmenorrhea patients. Methods: Eighty-nine young women with primary dysmenorrhea (PD) were selected as study group. PD pain was graded using Visual Analogue Scale (VAS), as mild, moderate and severe. Serum ADMA levels was measured in all subjects. Results: Mean age of study population was 21.08±2.21 and mean VAS score was 5.9101±2.18. Serum ADMA levels were 35.2(24) in mild, 54.0(28.7) in moderate and 56.5(32.8) in severe pain groups, (P= 0.029 and P=0.001, respectively). Mean ADMA levels difference were -18.8, p=0.046 in mild to moderate; -2.52, p=0. 945 in moderate to severe and 21.32 p=0.048 in severe to mild pain groups. Conclusion: Menstrual pain intensity is correlated with the serum ADMA levels as assessed by VAS pain score in PD patients