The Antioxidant Effect of Fraxin against Acute Organ Damage in Polymicrobial Sepsis Model induced by Cecal Ligation and Puncture

Abstract

Aim: In this paper, it was purposed to evaluate the antioxidant effect of fraxin against acute organdamage induced by cecal ligation and puncture model (CLP) in rats. Material and Methods: For thispurpose in our study, all experimental animals were randomly grouped. These groups were stated as shamcontrol, CLP, CLP+Fraxin 50 mg/kg, CLP+Fraxin 100 mg/kg groups. TAS, TOS, OSI, MDA levels, MPOand SOD activities were evaluated in kidney and lung tissues of all rats. Results: TOS, OSI, MDA levels andMPO activity of kidney and lung tissues were higher in the CLP group than in the sham-control group, butTAS level and SOD activity were lower. However, these results were significantly changed in the fraxintreatment groups. Conclusion: In light of these results, it can be stated that fraxin shows a positive effect byraising the level of SOD and TAS by decreasing TOS, MPO and MDA levels on kidney and lung tissue in themodel of sepsis caused by CLP.