EVALUATION OF SERUM LEVELS OF NETRIN-1 AS A POTENTIAL BIOMARKER FOR EARLY PREDICTION OF PREDIABETES

Abstract

Objectives: Prediabetes is a candidate status for Type 2 diabetes, typically identified glycemic values range above normal but below diabetes thresholds. Early and accurate diagnosis of this period would be helpful to prevent the diabetes and its consequences. Netrin-1 is a potential metabolic biomarker that has been associated with diabetes. Previous studies are scarce and have yielded contrasting results on serum netrin-1 levels in diabetes. The aim of this study was to investigate the correlation between serum netrin-1 levels and prediabetes. Methods: Sixty nine participants with prediabetes and 35 healthy controls were included in this study. Serum netrin-1 levels were determined using the Enzyme Linked Immunosorbent Assay (ELISA) method. Correlation analysis were done to assess the relationship between serum netrin-1 levels and biochemical parameters. Results: Serum netrin-1 levels were significantly decreased in the prediabetes group compared to the healthy control group (P