A Novel One-Pot Green Synthesis and Characterization of Substitue Bis-Iminothiazolidinones

Abstract

In this study, some new 5-substituted bis-iminothiazolidinone derivatives have been synthesized via one-pot green synthesis. The study comprises two steps. In the first step, bis-thioureas were prepared by the reaction of aryl isothiocyanates with substituted amines. In the second step, substituted bis-thioureas prepared beforehand and chloroacetic acid were condensed with substituted thiophene-2-carboxaldehydes and new 5-substituted bis-iminothiazolidinone compounds were obtained. The structures of all these synthesized compounds were determined and characterized by infrared, nuclear magnetic resonance and mass spectral data.