SavedAdd your journal

Journals / Journal of the Turkish Chemical Society Section A: Chemistry / 2019 / Cilt: 6 - Sayı: 3

ANTICANCER ACTIVITIES OF EVEN NUMBERED MONOKETO EICOSANOIC ACID ANILIDES AND SEMICARBAZONES

Hülya ÇELİK ONAR, Fatma Ceren ANLAŞ, Hasniye YAŞA, Fulya ÜSTÜN ALKAN, Belma HASDEMİR, Tülay BAKIREL

Pages
429–432
DOI
—

Abstract

This study was undertaken to examine the possible cytotoxic effect of anilide and semicarbazone derivatives of (4-12) monoketo eicosanoic acids (3.125 – 100 µM) on canine mammary tumour cell line (CMT-U27) as compared with doxorubicin. Among these compounds, 8-semicarbazone eicosanoic acid (3) and 10-keto eicosanoic acid anilide (9) displayed effective cytotoxic potential against CMT-U27 and IC50 concentrations were recorded at 1.952 µM and 54.00 µM, respectively.