A novel diagnostic tool in determining insulin resistance in obese children: Triglyceride / HDL ratio

Abstract

Background/Aim: It is known that the frequency of obesity and insulin resistance is increased in children. Diagnostic laboratory criteria of insulin resistance are unclear in children despite the widespread use of the Homeostasis model assessment for insulin resistance (HOMA-IR). Serum triglyceride (TG)/high-density lipoprotein (HDL) ratio is reported to reflect insulin resistance in recent studies. We aimed to investigate the usefulness of the TG/HDL ratio in determining insulin resistance and its correlation with the HOMA-IR index in overweight/obese children. Methods: Patients who presented to the Pediatric Endocrinology outpatient clinic with excessive weight were examined in this retrospective cohort study. The patients were divided into subgroups according to BMI, sex, pubertal stage, and presence of hepatosteatosis, and the HOMA-IR index and TG/HDL ratios were compared. Results: One hundred and fifty-nine patients aged 5-18 years, with a mean age of 11.4 (3.13) years, were included in the study. Of the patients, 93 (58%) were girls, 99 (62%) were pubertal, and 141 (88.6%) were obese. Seventy-nine (49.6%) patients had insulin resistance. The mean HOMA-IR and TG/HDL were 3.89 (2.29) and 2.71 (1.86), respectively. A positive correlation was found between HOMA-IR value and TG / HDL ratio (r= 0.283, P