Journals / Journal of Contemporary Medicine / 2017 / Cilt: 7 - Sayı: 2
Low plasminogen activator inhibitor-1 levels in thyroid carcinoma: uPA/PAI-1 paradox in cancer proggression
- Pages
- 120–125
- DOI
- —
Abstract
Aim: Plasminogen activator inhibitor-1 (PAI-1) potently inhibits cell migration and apoptosis. Increased levels of PAI-1 were demonstrated in a great variety of cancers. Many studies demonstrated increased expression of PAI-1 in thyroid cancer and its relation to unfavorable clinical outcome. In this study, we aimed to investigate serum PAI-1 levels in patients with papillary thyroid carcinoma (PTC) as well as its effect in development and size of PTC.Material and methods: Fifty-four papillary thyroid cancer patients (7 male, 47 female) and 24 healthy controls (6 male, 18 female) were enrolled in the study. Groups were compared by demographic, anthropometric, biochemical data, and by serum ghrelin levels. Serum PAI-1 levels were measured by enzyme-linked immunosorbent assay (ELISA).Results: Mean age were similar between PTC and control group (42.4 ± 10.1 to 42.5 ± 8.9, p:0.794). Serum PAI-1 levels were lower in patients with PTC when compared to healthy controls (241.34 ± 107.82 to 327.24 ± 138.51, p:0.011). BMI, Homa-IR and TSH, FT4, anti-TPO, anti-Tg, total cholesterol, triglyceride, HDL-Cholesterol, LDL-Cholesterol, calcium, phosphorus, 25-OH-VitD, parathormone, glucose, insülin concentrations were similar between groups (p>0.05). PAI-1 concentrations were not correlated with clinical, biochemical and hormonal parameters except parathormone (PTH) concentrations in PTC group (r:-0.446, p:0.0027).Conclusions: Serum PAI-1 levels were lower in patients with papillary thyroid carcinoma. Our results might support the thesis of PAI-1 is expected to suppress cancer progression due to its ability to inhibit urokinase plasminogen activator activity.
Özet
Amaç: Plazminojen aktivatör inhibitor-1 (PAI-1) hücre migrasyon ve apoptozisinin güçlü inhibitörüdür. Çoğu kanser türünde yüksek PAI-1 düzeyleri tespit edilmiştir. Bir çok çalışmada tiroid kanserlerinde artmış PAI-1 ekspresyonu ve bunun kötü klinik sonuçlarla ilişkili olduğu gösterilmiştir. Bu çalışmada papiller tiroid kanserlerinde(PTK) serum PAI-1 düzeylerini ve bunun PTK gelişimi ve boyutu üzerine etkisini araştırmak amaçlanmıştır.