Isolated Triterpenes from Stingless Bee Lisotrigona furva Propolis in Vietnam

Abstract

Stingless bees of the genus Lisotrigona are uncommon species found in India and South East Asian countries. Several Lisotrigona species including L. cacciae, L.carpenteri and L. furva from Vietnam have been described. There has been no information on the chemical constituents and bioactivity of Lisotrigona stingless bee propolis in Vienam. Our goal of this work is to investigate the chemical constituents of the stingless bee Lisotrigona furva propolis collected in Binhdinh province, Vietnam. Using combined chromatographic methods, several triterpenes including mangiferolic acid (1), occotilones I (2) and II (3), dipterocarpol (4), hydroxyhopanone (5) and (13E,17E)-polypoda-7,13,17,21-tetraen-3β-ol (6) were isolated from the ethyl acetate extract of Lisotrigona furva propolis. The chemical structures of isolated compounds were identified by MS, NMR spectral analysis. Compound 5 and 6 were isolated for the first time from stingless bee propolis.