Journals / Hacettepe Üniversitesi Eczacılık Fakültesi Dergisi / 2011 / Sayı: 1
Antimicrobial Screening of 2-Methyl-3- Acyl-4-Aryl-2,6,6 and / or 2,7,7-Trimethyl1,4,5,6,7,8-Hexahydroquinoline Derivatives
- Issue
- 2011 · Sayı: 1
- Pages
- 51–58
- DOI
- —
Abstract
In this study, thirty compounds having methyl ethyl 2,6,6- or 2,7,7-trimethyl-5-oxo-4- difluorosubstituted phenyl -1,4,5,6,7,8-hexahydroquinoline- 3-carboxylate and N,N-diethyl-2,6,6- or 2,7,7-trimethyl- 5-oxo-4- difluorosubstituted phenyl -1,4,5,6,7,8-hexahydroquinoline-3- carboxamide structure, have been screened for their antimicrobial activities. Antimicrobial activities were determined as minimum inhibitory concentration MIC values by broth microdilution method against bacteria and fungi.
Özet
Bu çalışmada metil etil 2,6,6- veya 2,7,7-trimetil-5-okso-4- difluorosübstitüe fenil -1,4,5,6,7,8-hekzahidrokinolin-3-karboksilat ve N,N-dietil-2,6,6- veya 2,7,7-trimetil-5-okso-4- difluorosübstitüe fenil -1,4,5,6,7,8-hekzahidrokinolin-3-karboksamit yapısına sahip otuz bileşiğin antimikrobiyal aktivitesi taranmıştır. Bakteri ve funguslara karşı antimikrobiyal aktiviteleri broth mikrodilüsyon yöntemi kullanılarak minimum inhibitör konsantrasyonu MIC olarak saptanmıştır.