Journals / Turkish Journal of Medical Sciences / 2002 / Cilt: 32 - Sayı: 4
Age and Gender Associated Changes in Cystatin C and b 2 -Microglobulin
- Pages
- 317–321
- DOI
- —
Abstract
Assessment of renal function in clinical medicine is of great importance. Various studies report that cystatin C (cysC) and b 2 -microglobulin are valuable markers of renal function. In this study, serum cysC and b 2 -microglobulin were measured in parallel with serum creatinine in a healthy population, and the characteristics of the relationship of cysC and b 2 -microglobulin to age and gender were compared. Serum creatinine, cysC and b2-microglobulin were measured in 119 (86 female; 33 male, 6 to 69 years old) healthy subjects. They were divided into five different age groups: group 1 (6-15 years, n = 10), group 2 (16-30 years, n = 34), group 3 (31-45 years, n = 34), group 4 (46-60 years, n = 29) and group 5 (>61 years, n = 12). Serum creatinine did not differ among groups and was not correlated with age. Creatinine values were significantly different (p = 0.004) between males and females. CysC values differed neither by gender nor by age in the groups. However, cysC exhibited a positive correlation with age (r = 0.212, p = 0.021). b 2 -microglobulin levels showed a significant difference between groups (p = 0.036). There was a positive correlation between serum b 2 -microglobulin and age (r = 0.188, p = 0.041). In conclusion, serum cysC and b 2 -microglobulin levels in healthy individuals increase with ageing, consistent with the decrease in GFR.
Özet
Assessment of renal function in clinical medicine is of great importance. Various studies report that cystatin C (cysC) and b 2 -microglobulin are valuable markers of renal function. In this study, serum cysC and b 2 -microglobulin were measured in parallel with serum creatinine in a healthy population, and the characteristics of the relationship of cysC and b 2 -microglobulin to age and gender were compared. Serum creatinine, cysC and b2-microglobulin were measured in 119 (86 female; 33 male, 6 to 69 years old) healthy subjects. They were divided into five different age groups: group 1 (6-15 years, n = 10), group 2 (16-30 years, n = 34), group 3 (31-45 years, n = 34), group 4 (46-60 years, n = 29) and group 5 (>61 years, n = 12). Serum creatinine did not differ among groups and was not correlated with age. Creatinine values were significantly different (p = 0.004) between males and females. CysC values differed neither by gender nor by age in the groups. However, cysC exhibited a positive correlation with age (r = 0.212, p = 0.021). b 2 -microglobulin levels showed a significant difference between groups (p = 0.036). There was a positive correlation between serum b 2 -microglobulin and age (r = 0.188, p = 0.041). In conclusion, serum cysC and b 2 -microglobulin levels in healthy individuals increase with ageing, consistent with the decrease in GFR.