Management of infertility in premature ovarian failure: A case report and literature review

Abstract

We herein present a case of pregnancy in a 39-year- old woman with secondary amenorrhea, hypergonadotropinemia, and hypoestrogenemia achieved after the use of hormone replacement therapy for two months. This has made us review the literature to search for the pregnancies reported on patients with premature ovarian failure. Surprisingly, we have found 43 pregnancies in 37 cases. It was also interesting to see that hormone replacement therapy had been included in the treatment protocol in about 55 % of the pregnancies and 23 % had occurred spontaneously. The treatment modalities and their mechanism of action are discussed.