Journals / Marmara Medical Journal / 2002 / Cilt: 15 - Sayı: 1
APROTININ IMPROVES Ca2+ - Mg2+ / ATPase LEVELS İN ISCHEMIA-REPERFUSION INJURY1'2
- Journal
- Marmara Medical Journal
- Pages
- 23–26
- DOI
- —
Abstract
Objective: The aim of this study is to determine the effect of aprotinin, on calcium activated and magnesium dependent adenosine 5’ triphosphatase (Ca2+-Mg2+/ATP ase) levels.Methods: Twenty patients who had elective coronary artery bypass grafting (CABG) were randomly divided into two groups (n= 10, in each). Group A patients received full dose aprotinin (20 000 lU/kg as pretreatment followed by 7500 lU/kg for 6 hours) and Group B patients received normal saline as control group. Erythrocyte membrane Ca2+-Mg2+/ATP ase levels were measured.Results: Ca2*-Mg2+ /ATPase levels were protected in aprotinin group, 807.60+32.62 vs 634.28+22.91 (p<0.05) at post-operative 24th hour. (p<0.05).Conclusion: Aprotinin protected the erythocyte membrane Ca2<-Mg2+ ATP/ase from oxidant stress thus it might affect the cell membrane stabilization.Key Words: Aprotinin, Ischemia-Reperfusion injury, Ca2t-Mg2+/ATPase.