Neoadjuvant treatment in locally advanced rectal cancer

Abstract

The optimal treatment for locally advanced rectal cancerremains an issue of debate. The surgery with total mesorectalexcision (TME) still is the standard of care. In contrast toTME, the addition of adjuvant or neoadjuvant therapy isnecessary in terms of local disease control and to increase ofsurvival time. Here, we will review neoadjuvant treatmentapproach in rectal carcinoma.Keywords: Rectal neoplasms, Neoadjuvant therapy,Radiotherapy, Chemotherapy