Protective effect of melatonin on the rat lung following exposure to a 900-MHz electromagnetic field: a stereological and histopathological study

Abstract

Long-term use of cell phone has increased concerns regarding histopathological change in vital organs. Our present study was aimed to investigate the effect of EMF on the rat lungs, as well as the possible efficacy of melatonin (MEL) on lung tissues. Fifteen female wistar albino rats were randomly selected and assigned into five groups as follow: control (CONT), SHAM, EMF, melatonin (MEL) and EMF+MEL group. Subsequently, female rats were then mated, and pregnant rats underwent the experimental application for 21 days. After parturition, 6 pups (2 pups from each mother) were randomly chosen and maintained for 4 weeks. At the end of the 4th week, the lung tissues of all groups were used for the stereological analysis and histopathological examination. We found that the mean volumes of the alveoli, bronchioles and blood vessels were significantly lower in the EMF group compared to the control group (p