Variation in Turkish Patients with Colorectal Cancer

Abstract

Introduction: Leukocyte function-associated antigen 1 (LFA-1) is expressed on leukocyte surfaces and interacts with the intercellular adhesion molecules. Since LFA-1 may have roles in tumor survival and growth, so we aimed to investigate the effects of rs2230433 variation on. Methods: Sixty-seven healthy subjects without any cancer history as control group and 100 subjects diagnosed with col- orectal cancer as patient group were included in our study. DNA isolated from the blood samples and polymerase chain reaction-restriction fragment length polymorphism methods were performed. Statistical analysis was performed using SPSS software for Windows, version 22.0 and p0.05). Discussion and Conclusion: Our results showed that LFA-1 rs2230433 is not associated with colorectal cancer.