Journals / Anadolu Tıp Dergisi / 2000 / Cilt: 2 - Sayı: 2
The relation between P53 and proliferating cell nuclear antigen (PCNA) expression with histological grade in the prostate adenocarcinoma
- Journal
- Anadolu Tıp Dergisi
- Pages
- 101–106
- DOI
- —
Abstract
Forty cases with prostate carcinoma that are diagnosed at Pathology Department of Dicle University between 1996 and 1998 were included in this study. Slides of the cases were stained with p53 and PCNA, and the correlation between grade and Gleason score for each patient was investigated. According to Gleason scores, of our cases, 2 (5%) were grade I, 12 (30%) were grade II, 7 (18%) were grade III, 11 (27%) were grade IV and 8 (20%) were grade V. The p53 positivity was not observed in any of the grade I and grade II cases, but positive staining was determined in one out of grade III, two out of grade IV and three out of grade V cases. Average of PCNA index of grade I, grade II, grade III, grade IV and grade V cases was 1.310.5, 2.1±1.1, 4.7±2.3, 6.5±2.5, and 7.3±3.8 respectively, and average of the cases was 4.4±2.0. There was a significant correlation between grade and Gleason score with p53 and PCNA (p
Özet
Bu çalışmada Dicle Üniversitesi Tıp Fakültesi Patoloji Anabilim Dalı'nda 1996-1998 yılları arasında prostat kanseri tanısı alan 40 olgu incelendi. Olgulara ait kesitler p53 ve PCNA ile boyanarak grade ve Gleason skoru arasındaki ilişki araştırıldı. Gleason'a göre olgularımızın 2'si grade I(%5), 12'si grade II(%30), 7'si grade III(%18), II'i grade IV(%27) ve 8'i grade V(%20) idi. Grade I ve grade II olgularımızda p53 ile pozitiflik izlenmezken, grade III olgularımızın I'inde ve grade IV olgularımızın 2'sinde, grade V olgularımızdan ise 3'ünde pozitif boyanma saptandı. PCNA ile grade I olguların ortalama PCNA indeksi 1.310.5, grade II olguların 2.1±1.1, grade III olguların 4.7±2.3, grade IV olguların 6.5±2.5, grade V olguların 7.3±3.8 ve genel ortalama 4.4±2.0 idi. Grade ve Gleason skorları ile p53 ve PCNA arasında anlamlı bir ilişki vardı (p