The Protective Effect of Melatonin on Plasma Lipid Profile in Rats with Cerulein-induced Acute Pancreatitis

Abstract

The objective of this study was to assessment the effect of melatonin on lipid profile in rats with experimentally induced acutepancreatitis. In this study, 32 adult, male, healthy Wistar Abino rats were used. Group I animals was no applied. Group IIanimals was intraperitoneally administered 50 mg/kg melatonin per rat twice for two hours intervals. Animals of group IIIreceived two intraperitoneal injections of cerulein (50 µg/kg and 25 µg/kg bw, respectively) at two hours intervals.Animals ofgroup IV received two intraperitoneal injections of cerulein (50 µg/kg and 25 µg/kg bw, respectively) at two hours intervals andthe rats received an intraperitoneal injection of 50 mg/kg melatonin 30 min before each cerulein injection.After 12 hours fromthe last cerulein injection, total cholesterol, triglyceride, LDL, HDL levels was determined.In this study, experimentally inducedacute pancreatitis resulted in significantly increase in levels of total cholesterol, triglyceride and LDL (p