Assessment of diastolic function in children and adolescents with beta-thalassemia major by tissue Doppler imaging

Beta talasemi majorlu çocuk ve ergenlerde doku Doppler yöntemiyle diyastolik işlevlerin değerlendirilmesi

Aygün DİNDAR, Kemal NİŞLİ, Naci ÖNER, Ümrah AYDOĞAN, Zeynep KARAKAŞ, Eker Rukiye ÖMEROĞLU, Taner YAVUZ, Gönül AYDOĞAN, Zafer ŞALCIOĞLU, Türkan ERTUĞRUL

Abstract

Aim: The purpose of this study was to analyze myocardial diastolic function in patients with beta-thalassemia major before development of overt cardiomyopathy using pulsed wave tissue Doppler imaging, and compare data with conventional Doppler echocardiography. Material and Method: The study included 61 beta-thalassemia major subjects (age 4 to 20 years; mean age, 10.7±4.1 years; 32 females and 29 males) with normal left ventricular function and 52 healthy control subjects, matched for age and sex. All participants underwent M-mode echocardiography and left ventricular systolic function was measured; diastolic functions of the right and left ventricul were analysed using issue Doppler imaging and conventional Doppler echocardiography. SPSS for Windows 13.0 software programme was used for statistical analysis, and the student’s t-test was used to compare data. This study was approved by the ethics committee of the ‹stanbul Medical Faculty. Results: Body surface area was significantly smaller in the patients than in the controls (1.0±0.2 vs. 1.2±0.3 m2, p

Özet

Amaç: Bu çal›flmada belirgin kardiyomiyopati tablosu geliflmemifl beta talasemi majorlu çocuk ve ergenlerde doku Doppler yöntemi ile miyokard›n diyastolik ifllevlerini incelemek ve bu verileri geleneksel Doppler verileri ile karfl›laflt›rmak amaçland›. Gereç ve Yöntem: Sol ventrikül sistolik ifllevleri normal olan 61 beta talasemi major olgusu (4-20 yafl, ortalama: 10,7±4,1 y›l; 32 k›z, 29 erkek) ile yafl ve cinsiyet aç›s›ndan hasta grubu ile uyumlu 52 kontrol olgusu çal›flmaya al›nd›. Hasta ve kontrol grubunda M-mode ekokardiyografi, sol ventrikülün sistolik ifllevi ölçüldü; sa¤ ve sol ventrikülün diyastolik ifllevleri doku Doppler ve geleneksel Doppler tekni¤i ile de¤erlendirildi. ‹statistik analizler SPSS for Windows 13.0 program› kullan›larak yap›ld›, veriler student-t testi ile karfl›laflt›r›ld›. Bu çal›flma ‹stanbul T›p Fakültesi Etik Komitesi’nce onayland›. Bulgular: Hasta grubunda vücut yüzey alan› (1,0±0,2 m2) kontrol grubundan (1,2±0,3 m2) daha küçük idi p