Türkiye’deki hpv tipleri: Türk jinekolojik onkoloji grubuna üye merkezlere başvuran 6388 hastanın retrospektif analizi

HPV types in Turkey: Multicenter hospital Based evaluation of 6388 patients in Turkish gynecologic oncology group centers

İbrahim ALANBAY, Levent KESKİN, Ali HABERAL, Anıl ONAN, Işık ÜSTÜNER, Çağatay TAŞKIRAN, Müge HARMA, Yusuf ERGÜN, Hüseyin AYDOĞMUŞ, Müfit YENEN, Mete ÇAĞLAR, Hakan YETİMALAR, Salim ŞEHİRALİ, Haldun GÜNER, Filiz AVŞAR, Mustafa ÖZAT, Mustafa BASARAN, M. Coşkun SALMAN, Jale METİNDİR, Levent MUTLU, Emre

Abstract

Objective:To evaluate the prevalence of HPV DNA and cervical cytological abnormalities, to compare cervical cytology results and HPV DNA and to define HPV types distribution in a large series of Turkish women who have undergone HPV analysis in hospitals that are members of the Turkish Gynecological Oncology Group. Material and Method:Between 2006 and 2010, a total of 6388 patients’ data was retrospectively evaluated at 12 healthcare centers in Turkey. Demographic characteristics, cervical cytology results, HPV status and types were compared.Results:The mean age of the patients was 38.9±10.2. Overall, 25% of the women were found to be HPV positive. Presence of HPV-DNA among patients with abnormal and normal cytology was 52% and 27%, respectively. There was significant diff erence with respect to decades of life and HPV positivity (p < 0.05). HPV was positive in(within the HPV (+) patients) 37%, 9%, 27%, 20%, 22%, and 41% of the ASCUS, ASC-H, LSIL HSIL, glandular cell abnormalities, and SCC cases respectively The most common HPV types in our study were as follows; HPV 16 (32%), HPV 6 (17%), HPV 11 (9%), HPV 18 (8%), HPV 31 (6%), HPV 51 (5%), HPV 33 (3%). Conclusion:In this hospital based retrospective analysis, HPV genotypes in Turkish women with normal and abnormal cytology are similar to those reported from western countries. Further population based prospective multicenter studies are necessary to determine non-hospital based HPV prev alence in Turkish women

Özet

Amaç:Türkiyedeki HPV tiplerinin geniş bir seri ile ortaya konması amacı ile Türk Jinekolojik Onkoloji grubuna üye hastanelerde HPV analizi yapılan hastaların sonuçlarının retrospektif olarak değerlendirilmesi ve sitolojik anormalliklerdeki HPV tiplerinin belirlenmesi.Gereç ve Yöntem:2006 ve 2010 yılları arasında 12 ayrı merkeze başvuran smear ve HPV analizi yapılan toplam 6388 hasta retrospektif olarak incelenmiştir. Hastaların demografik bilgileri, smear sonuçları, HPV tipleri online olarak toplanıp analiz edilmiştir. Bulgular:Ortalama hasta yaşı 38.9±10.2 idi. Tüm grup değerlendiril- diğinde, %25 hastada HPV pozitif olarak saptandı. Anormal sitolojisi olanlarda HPV pozitifliği %57 iken normal pap testi olanlarda HPV pozitifliği %27 oranında tespit edildi.Hastaların yaşam dekadları ile HPV pozitifliği arasında anlamlı bir ilişki bulundu (p