False-Positive Laryngeal FDG Uptake During PET/CT Imaging: Reinke’s Edema

Abstract

Positron emission tomography/computed tomography (PET/CT) is frequently used for diagnosing,staging, and following-up various malignancy typesbecause it provides information on the site and metabolic activity of the tumor. Fluorodeoxyglucose(FDG) uptake by the normal laryngeal tissue is symmetric and low, whereas that under some non-malignant conditions of the larynx, such as vocal cordparalysis and Teflon granuloma, is asymmetricallyincreased. We reported the first case of histologicallyproven Reinke’s edema causing false-positive laryngeal FDG uptake on PET/CT imaging. A clinicianmust be aware of these rare benign lesions in the caseof increased FDG uptake, and histopathological investigation is mandatory to rule out malignancy forsuspicious cases.