Comparison of Three-Dimensional Conformal Radiation Therapy, Intensity-Modulated Radiation Therapy, and Volumetric-Modulated Arc Therapy In Glioblastoma Multiforme Radiation Therapy With EORTC Target Delineation

Abstract

OBJECTIVEIn this study, three-dimensional conformal radiation therapy (3D-CRT), intensity-modulated RT(IMRT), and volumetric-modulated arc therapy (VMAT) techniques were compared in patients withglioblastoma multiforme (GBM) receiving RT. Comparisons were made in terms of sparing the organsat risk (OAR), by using European Organisation for Research and Treatment of Cancer-Advisory Committee on Radiation Oncology Practise (EORTC-ACROP) guideline.METHODSRT in 10 patients was replanned. Treatment volume was created according to the EORTC-ACROP, and60 Gy/30 fraction dose was prescribed for planning target volume (PTV). PTV-less brain volume (BPTV) Dmean, OARs doses; V5Gy and V50Gy of B-PTV volumes; conformality, and homogeneity indices were analyzed.RESULTSB-PTV was spared better in IMRT. The optic chiasm, contralateral optic nerve, ipsilateral/contralateralcochlea were significantly spared in IMRT and VMAT. The best sparing for brainstem, pituitary gland,ipsilateral eye, ipsilateral lacrimal gland was obtained with VMAT. B-PTV volume received at least 5 Gywas similar in three plans, but lower with 50 Gy in IMRT and VMAT (p