Hydrogel Spacer may Allow Prostate Re-irradiation even in Patients with Ulcerative Colitis: A Case Report

Abstract

Salvage radiotherapy is a valid option for locally recurrent prostate cancer (PC) patients. Two of thetreatment options are as follows: interventional radiotherapy or stereotactic body radiotherapy (SBRT).SBRT has the main advantage as a noninvasive procedure. Synthetic gel injection into the prostate andrectum space, as a novel technique in prostate radiotherapy, spares the anterior rectal wall from a highdose. Inflammatory bowel disease, including Crohn’s disease and ulcerative colitis (UC), contraindicateexternal beam radiotherapy due to increased bowel complication risk. In this study, we describe the firstPC patient with UC in remission treated with salvage SBRT and hydrogel rectal spacer. After ten monthsof follow-up, no bowel symptoms were reported, and SBRT provided both biochemical and clinical response. Even patients with UC and radio-recurrent PC may be viable salvage SBRT candidates.