The Relationship of Ki-67 Over-expression with Clinicopathological Prognostic Parameters in Invasive Breast Carcinomas

Abstract

OBJECTIVE Immunohistochemical Ki-67 index is a useful method to determine the prognosis. We aimed to evaluate the association of Ki-67 score, using 14% and 20% cut-off values, with clinicopathological parameters in invasive breast carcinomas. METHODS Pathology reports of 162 females were retrospectively reviewed and parameters including age, menopausal status, multifocality/multicentricity (MF/MC), tumor size, histological type, grade, lymphovascular invasion (LVI), perineural invasion, axillary lymph node status, ER, PR, HER2 status, Ki-67 index, and molecular subtype were recorded. The cases were grouped according to two separate Ki-67 cut-off values (high: ≥14% and ≥20%, low