Early Effect of Radiotherapy on Serum Levels of HSP70 and S100B in Patients with Breast Cancer

Abstract

OBJECTIVE This study aimed to evaluate the difference between serum levels of S100B and HSP70 in the non-meta- static, Luminal A breast cancer (BC) patients with the healthy population, and determine the impact of post-operative radiotherapy (RT) on serum markers. METHODS 21 BC patients who underwent chest wall/breast±axillary RT after adjuvant chemotherapy and twenty- one healthy individuals were included in the study group. The changes in serum HSP70 and S100B levels were observed in the study and control groups. RESULTS A total of 42 participants were included. A significant difference was found between the HSP70 and S100B measurements of the study and control groups before and after RT (P=0.001 and p