Analysis of Clinical and Laboratory Findings of Secondary Amyloidosis

Abstract

OBJECTIVE: Our aim was to investigate the clinical and laboratory findings of patients with AAamyloidosis. MATERIAL and METHODS: Fifty-nine patients with AA-amyloidosis were included in this study. The patients were divided into 2 groups. Group-1 consisted of 23 patients with AA-amyloidosis due to familial mediterranean fever (FMF) and Group-2 consisted of 36 patients with AA-amyloidosis due to etiologies other than FMF. The laboratory and clinical characteristics of all patients were compared between groups. RESULTS: Of the patients, edema was found in 47 (79.6%), hepatomegaly in 8 (13%), splenomegaly in 9 (14.7%), and hypertension in 21 (35.6%). The median age, systolic/ diastolic blood pressure, serum albumin, total cholesterol, creatinine, and proteinuria values of Group-1 and Group-2 were 29 (16- 73) and 50 (16-76) years (p: 0.001)., 135±12.4 / 73.1±9.2 and 133±13.1 / 72.4±8.9 mmHg (p>0.05), 3.33±0.86 and 2.60±0.92 mg/dl (p:0.04), 238.08±115.68 and 227.77±82.52 mg/dl (p>0.05), 2.51±2.74 and 3.81±3.31 mg/dl (p>0.05), 4.35±3.53 and 5.58±5.10 g/day (p>0.05) respectively. Renal replacement therapy (RRT) was performed in 5 patients in Group-1 and 11 patients in Group-2. CONCLUSION: The most common cause of AA-amyloidosis in our study was FMF, followed by bronchiectasis and chronic obstructive pulmonary disease. Patients with amyloidosis due to FMF were younger than the patients with amyloidosis due to other etiologies. The need for RRT was similar between the group

Özet

AMAÇ: Çalışmamızda AA-amiloidozlu hastaların klinik ve laboratuvar bulgularının incelenmesiamaçlanmıştır.GEREÇ ve YÖNTEMLER: Çalışmaya AA-amiloidoz’u olan 59 hasta dahil edildi. Hastalar iki grubaayrıldı. Grup-1 Ailevi Akdeniz Ateşine (FMF) bağlı AA-amiloidozlu 23 hasta ve Grup-2 FMF hariciAA-amiloidozlu 36 hastadan oluşmaktaydı. Tüm hastaların laboratuvar ve klinik bulguları gruplar arasıkarşılaştırıldı.BULGULAR: Ödem 47 (%79.6), hepatomegali 8 (%13), splenomegali 9 (%14.7), hipertansiyon 21(%35.6) hastada saptandı. Ortanca yaş, sistolik/diastolik kan basıncı, serum albumin, total kolesterol,kreatinin, proteinüri değerleri Grup-1 ve Grup-2 için sırasıyla: 29 (16-73) ve 50 (16-76) (p: 0.001),135±12.4 / 73.1±9.2 ve 133±13.1 / 72.4±8.9mmHg (p > 0.05), 3.33±0.86 ve 2.60±0.92 mg/dl (p:0.04),238.08±115.68 ve 227.77±82.52mg/dl (p>0.05), 2.51±2.74 ve 3.81±3.31mg/dl (p>0.05), 4.35±3.53 ve5.58±5.10 g/gün (p>0.05) idi. Grup-1’de 5 hasta (%21.7), Grup-2’de 11 hasta (%30.6) renal replasmantedavisi (RRT) alıyordu (p: 0,458).SONUÇ: Çalışmamızda en sık neden FMF, ikinci sırada bronşektazi idi. FMF’e bağlı amiloidozuolan hastalar, diğer etiyolojilere bağlı amilodozu olanlara göre daha gençti. RRT ihtiyacı her iki gruptabenzer saptandı.