Journals / Türk Kardiyoloji Derneği Arşivi / 2010 / Cilt: 38 - Sayı: 3
The relationship between insulin resistance and left ventricular systolic and diastolic functions and functional capacity in patients with chronic heart failure and metabolic syndrome
- Pages
- 173–181
- DOI
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Abstract
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Özet
Amaç: Kronik kalp yetersizliği (KKY) ile insülin direnci (İD) arasındaki ilişki uzun zamandır bilinmektedir. Çalışmamızda KKY olan metabolik sendromlu olgularda İD’nin sol ventrikül sistolik ve diyastolik fonksiyonu ve fonksiyonel kapasite ile olan ilişkisi araştırıldı.Çalışma planı: Metabolik sendromu olan 50 KKY hastası (NYHA sınıf I-III; 40 erkek, 10 kadın; ort. yaş 60±10) çalışmaya alındı. Diyabetin dışlandığı hasta grubunda metabolik sendrom tanısı AHA/NHLBI (American Heart Association/National Heart, Lung, Blood Institute) ölçütlerine göre kondu. İnsülin direnci için, homeostatik modelle değerlendirilen İD (HOMA-İD) hesaplandı. Sol ventrikül yapı ve fonksiyonu, nabızlı dalga Doppler ve doku Doppler görüntüleme yöntemleri kullanılarak ekokardiyografi ile değerlendirildi.Bulgular: Hastalar sol ventrikül ejeksiyon fraksiyonunun (EF) ≤%40 (n=25) ve >%40 (n=25) olmasına göre değerlendirildiğinde, EF ≤%40 olan grupta NYHA fonksiyonel sınıfı daha ileri (p