Journals / Türk Jinekoloji ve Obstetrik Derneği Dergisi / 2011 / Cilt: 8 - Sayı: 2
Bone mineral density and endogen sex steroid hormone association in postmenopausal healthy women
- Pages
- 118–124
- DOI
- —
Abstract
Objective: During menopause, decrease in estrogen levels as well as in androgen levels is the main cause of mineral loss in bone. In this study, we aimed to investigate the relationship between mineral density of femur neck-lumbar vertebral bones and endogen sex steroid hormone levels in postmenopausal healthy women. Material and methods: Estradiol[E2], total testosterone[TTE], free testosterone[FTE], dehydroepiandrostenedion sulfate[DHEAS], androstenedione and sex hormone-binding globulin[SHBG] measurements were performed, lumbar(L1-L4) and femur neck T scores were calculated with dual energy x-ray absorbsiometry method in 415 postmenopausal healthy women who referred to our clinic between 2006 June and 2007 May. Intermeasurement relationships and correlations were also investigated. Results: The mean age was 55.08±6.74(35-82) years, mean lumbar vertebral T scores was -1.23±1.36(-1,85-3,00), mean femur neck T scores was –0.56±3.24(-4,40-2,99), mean body mass index(BMI) was 26.99±4.23(18,31-40,00) and mean years since menopause was 8.90±7.20(1,00-50,00) years. In Pearson correlation analysis, lumbar vertebral T score correlated with age(p
Özet
Amaç: Bu çalışmada postmenopozal sağlıklı kadınlarda femur boynu ve lomber vertebral kemik mineral yoğunluğu ile endojen seks steroid hormon serum düzeyleri arasındaki ilişkinin araştırılması amaçlandı. Gereç ve yöntemler: Haziran 2006-Mayıs 2007 tarihleri arasında kliniğimize başvuran 415 postmenopozal sağlıklı kadında östradiol [E2], total testosteron [TTE], serbest testosteron [FTE], dihidroepiandrostenedion sülfat [DHEAS], androstenedion ve seks hormon bağlayıcı globulin [SHBG] ölçümleri yapıldı ve dual enerji x-ray absorbsiyometri yöntemi ile lomber vertebral (L1-L4) ve femur boynu T skorları hesaplandı. Ölçümler arası ilişki ve korelasyon araştırıldı. Bulgular: Hastaların yaş ortalaması 55,08±6,74(35-82), ortalama lomber vertebral T skoru -1,23±1,36 (-3,85-3,00), ortalama femur boynu T skoru -0,56±3,24(-4,40-2,99), ortalama vücut kitle indeksi (VKİ) 26,99±4,23 (18,31-40,00) ve ortalama menopoz süresi 8,90±7,20 yıl (1,00-50,00) olarak saptandı. Pearson korelasyonunda lomber vertebral T skoru ile yaş (p